MEN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEN1_MOUSE
• UniProt AC: O88559
• Protein Name: Menin
• Gene Name: Men1
• Organism: Mus musculus (Mouse).
• Sequence Length: 611
• Subcellular Localization: Nucleus . May be perinuclear in testis.
• Protein Description: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair..
• Protein Sequence: MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYQDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLETGEERTGEQAQGTQGQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVHIVSREAEAAEAEEPWGDEAREGRRRGPRRESKPEEPPPPKKPALDKGPGSGQSAGSGPPRKTSGTVPGTTRGGQEVGNAAQAPAPAASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MGLKAAQKTLF ----CCCHHHHHHHC	35.63	6569485
8	Acetylation	MGLKAAQKTLFPLRS CCCHHHHHHHCCCCC	42.33	6569245
210	Phosphorylation	NEDRRGQTVNAGVAE CCCCCCCEECHHHHC	20.67	-
487	Phosphorylation	RRGPRRESKPEEPPP CCCCCCCCCCCCCCC	52.26	25159016
518	Phosphorylation	GSGPPRKTSGTVPGT CCCCCCCCCCCCCCC	33.40	28066266
519	Phosphorylation	SGPPRKTSGTVPGTT CCCCCCCCCCCCCCC	35.19	28833060
521	Phosphorylation	PPRKTSGTVPGTTRG CCCCCCCCCCCCCCC	24.24	28066266
544	Phosphorylation	QAPAPAASPPPEGPV CCCCCCCCCCCCCCE	39.79	27087446
550	Phosphorylation	ASPPPEGPVLTFQSE CCCCCCCCEEEEECH	19.11	24719451
553	Phosphorylation	PPEGPVLTFQSEKMK CCCCCEEEEECHHHC	21.62	25619855
556	Phosphorylation	GPVLTFQSEKMKGMK CCEEEEECHHHCCCH	34.69	25619855
594	Phosphorylation	QMKKQKVSTPSDYTL HHHHCCCCCCCHHHH	41.45	28066266
595	Phosphorylation	MKKQKVSTPSDYTLS HHHCCCCCCCHHHHH	29.78	28066266
600	Phosphorylation	VSTPSDYTLSFLKRQ CCCCCHHHHHHHHHH	22.40	28059163
602	Phosphorylation	TPSDYTLSFLKRQRK CCCHHHHHHHHHHHC	22.26	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEN1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEN1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRE1A_MOUSE	Rnf20	physical	25591470

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.