KC1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KC1A_MOUSE
• UniProt AC: Q8BK63
• Protein Name: Casein kinase I isoform alpha
• Gene Name: Csnk1a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 337
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Localizes to the centrosome in interphase cells, and to kinetochore
• Protein Description: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity)..
• Protein Sequence: MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSSGSKA ------CCCCCCCCE	20.37	23806337
3	Phosphorylation	-----MASSSGSKAE -----CCCCCCCCEE	24.60	23984901
4	Phosphorylation	----MASSSGSKAEF ----CCCCCCCCEEE	29.22	23984901
5	Phosphorylation	---MASSSGSKAEFI ---CCCCCCCCEEEE	44.59	23984901
7	Phosphorylation	-MASSSGSKAEFIVG -CCCCCCCCEEEEEC	30.55	23984901
8	Acetylation	MASSSGSKAEFIVGG CCCCCCCCEEEEECC	56.30	23806337
59	Phosphorylation	ARHPQLLYESKLYKI CCCCHHHHHHHHHHH	27.09	24759943
62	Ubiquitination	PQLLYESKLYKILQG CHHHHHHHHHHHHHC	43.85	-
65	Acetylation	LYESKLYKILQGGVG HHHHHHHHHHHCCCC	47.58	22826441
65	Ubiquitination	LYESKLYKILQGGVG HHHHHHHHHHHCCCC	47.58	-
206	Phosphorylation	SRRDDMESLGYVLMY HHHHHHHHHHHHHHH	22.06	29895711
209	Phosphorylation	DDMESLGYVLMYFNR HHHHHHHHHHHHCCC	8.83	29895711
213	Phosphorylation	SLGYVLMYFNRTSLP HHHHHHHHCCCCCCC	8.11	29895711
225	Ubiquitination	SLPWQGLKAATKKQK CCCHHHHHHHHHHHH	42.68	-
250	Ubiquitination	TPVEVLCKGFPAEFA CCHHHHCCCCCHHHH	60.47	-
294	Phosphorylation	TLNHQYDYTFDWTML HCCCCCCCCCCHHHH	12.36	22817900
302	Ubiquitination	TFDWTMLKQKAAQQA CCCHHHHHHHHHHHH	38.64	-
304	Ubiquitination	DWTMLKQKAAQQAAS CHHHHHHHHHHHHHH	44.07	-
311	Phosphorylation	KAAQQAASSSGQGQQ HHHHHHHHCCCCCCC	28.22	23375375
311 (in isoform 2)	Phosphorylation	-	28.22	26643407
312 (in isoform 2)	Phosphorylation	-	33.49	26643407
312	Phosphorylation	AAQQAASSSGQGQQA HHHHHHHCCCCCCCC	33.49	23375375
313	Phosphorylation	AQQAASSSGQGQQAQ HHHHHHCCCCCCCCC	32.42	23375375
313 (in isoform 2)	Phosphorylation	-	32.42	26643407
321	Phosphorylation	GQGQQAQTPTGKQTD CCCCCCCCCCCCCCC	26.32	25521595
321 (in isoform 2)	Phosphorylation	-	26.32	25521595
323	Phosphorylation	GQQAQTPTGKQTDKT CCCCCCCCCCCCCCC	61.47	21743459
323 (in isoform 2)	Phosphorylation	-	61.47	26643407
327	Phosphorylation	QTPTGKQTDKTKSNM CCCCCCCCCCCCCCC	42.84	23375375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KC1A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KC1A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KC1A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN2_MOUSE	Cops2	physical	19576224

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.