RCC2_MOUSE - dbPTM
RCC2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RCC2_MOUSE
UniProt AC Q8BK67
Protein Name Protein RCC2
Gene Name Rcc2
Organism Mus musculus (Mouse).
Sequence Length 520
Subcellular Localization Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during an
Protein Description Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 (By similarity)..
Protein Sequence MPRKKGAAWEEPSSGNGTARAGPRRRGGPAGRKRERPERCSSSSGGGSSGDEDGPELDGAPGGGKRTARPATAGKAAGAAAIITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESEAEKEKLQRLPEYTPRTL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationGAAWEEPSSGNGTAR
CCCCCCCCCCCCCCC		54.9130635358
14PhosphorylationAAWEEPSSGNGTARA
CCCCCCCCCCCCCCC		47.1730635358
18PhosphorylationEPSSGNGTARAGPRR
CCCCCCCCCCCCCCC		19.5730635358
41PhosphorylationRERPERCSSSSGGGS
CCCCCCCCCCCCCCC		39.2025619855
42PhosphorylationERPERCSSSSGGGSS
CCCCCCCCCCCCCCC		31.9521082442
43PhosphorylationRPERCSSSSGGGSSG
CCCCCCCCCCCCCCC		19.3925619855
44PhosphorylationPERCSSSSGGGSSGD
CCCCCCCCCCCCCCC		43.3221082442
48PhosphorylationSSSSGGGSSGDEDGP
CCCCCCCCCCCCCCC		34.1325521595
49PhosphorylationSSSGGGSSGDEDGPE
CCCCCCCCCCCCCCC		54.2425521595
90AcetylationITEPEHTKERVKLEG
ECCCHHHCCCEEECC		45.4922826441
122AcetylationIGRKEVPKQQAAYRN
HCCCCCCHHHHHHHH		61.2823806337
142GlutathionylationWGPHRYGCLSGVRVR
CCCHHCCCCCCCEEE		1.7124333276
207GlutathionylationEAIVLAACGRNHTLA
HHHHHHHCCCCCEEE		4.3524333276
220PhosphorylationLALTDTGSVFAFGEN
EEEECCCCEEEEECC		19.0229514104
274PhosphorylationMDCKGNLYSFGCPEY
EECCCCEEECCCCCC		13.1225367039
275PhosphorylationDCKGNLYSFGCPEYG
ECCCCEEECCCCCCC		20.5225367039
278GlutathionylationGNLYSFGCPEYGQLG
CCEEECCCCCCCCCC		1.8724333276
281PhosphorylationYSFGCPEYGQLGHNS
EECCCCCCCCCCCCC		8.7025367039
291AcetylationLGHNSDGKFIARAQR
CCCCCCCCCEEEEEE		38.2923806337
303GlutathionylationAQRIEYDCELVPRRV
EEEEEECCEECCCEE		4.2224333276
316AcetylationRVAIFIEKTKDGQIL
EEEEEEEECCCCCEE		56.9322826441
318UbiquitinationAIFIEKTKDGQILPV
EEEEEECCCCCEECC		71.5727667366
318AcetylationAIFIEKTKDGQILPV
EEEEEECCCCCEECC		71.5723806337
335GlutathionylationVVVRDVACGANHTLV
EEEEEECCCCCCEEE		5.4824333276
340PhosphorylationVACGANHTLVLDSQK
ECCCCCCEEEEECCC		20.54-
357PhosphorylationFSWGFGGYGRLGHAE
EEECCCCCCCCCCHH		10.2322817900
375AcetylationEMVPRLVKLFDFPGR
CHHHHHHHHHCCCCC		48.2922826441
426GlutathionylationPKAVQDLCGWRIRSL
HHHHHHHHHHHEEEC		7.0824333276
435GlutathionylationWRIRSLACGKSSIIV
HHEEECCCCCCEEEE		9.5224333276
516PhosphorylationLQRLPEYTPRTL---
HHCCCCCCCCCC---		12.4827600695
519PhosphorylationLPEYTPRTL------
CCCCCCCCC------		37.7126824392
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RCC2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RCC2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RCC2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAC1_MOUSERac1physical
25074804
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RCC2_MOUSE

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Related Literatures of Post-Translational Modification

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