ZN281_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN281_MOUSE
• UniProt AC: Q99LI5
• Protein Name: Zinc finger protein 281
• Gene Name: Znf281
• Organism: Mus musculus (Mouse).
• Sequence Length: 893
• Subcellular Localization: Nucleus .
• Protein Description: Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes..
• Protein Sequence: MKIGSGFLSGGGGPSSSGGSGSGGSSGSASGGSGGGRRAEMEPTFPQSMVMFNHRLPPVTSFTRPAGTAAPPPQCVLSSSTSAAPAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSWGFLQSLVSIKQEKPADPEEQPSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSLLHQHAQQQPAQHHRDVLLSSGSRTDEHGNQEPKQDANVKKAKRPKPESQGIKAKRKPSASSKPLVGEGEGAVLSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEAIAKGAASAEPGSSNHNSMGNLAVLSQGNTSSSRRKSKSKSIAIENKEHKTGKTNESQMSNNINMQSYSVEMPTVSTSGSIIGTGIDELQKRVPKLIFKKGSRKNADKSYLNFVSPLPDVVGQKSLSGKPGGSLGIVSNNSVETISLLQSTSGKQGPISSNYDDAMQFSKKRRYLPTASSNSAFSINVGHMVSQQSVIQSAGVSVLDNEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSGKSETQKEDPFNLTEPRVDLHTSGEHSELVQEENLSPGTQTPSNDKTSMLQEYSKYLQQAFEKSTNAGFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQSSSQKLTSQKEQQKNLESSTSFQIPSQELASQIDPQKDIEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRVRTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MKIGSGFLSGGG ---CCCCCCCCCCCC		22871156
15	Phosphorylation	LSGGGGPSSSGGSGS CCCCCCCCCCCCCCC		-
33	Phosphorylation	SGSASGGSGGGRRAE CCCCCCCCCCCCCCC		22871156
106	Phosphorylation	FKKEPAASAAAFPSQ CCCCCCCCCCCCCCC		22942356
112	Phosphorylation	ASAAAFPSQRTSWGF CCCCCCCCCHHHHHH		22942356
115	Phosphorylation	AAFPSQRTSWGFLQS CCCCCCHHHHHHHHH		26643407
116	Phosphorylation	AFPSQRTSWGFLQSL CCCCCHHHHHHHHHH		26643407
159	Phosphorylation	FAGAEERSPGLGGGE CCCCCCCCCCCCCCC		22817900
197	Phosphorylation	HHRDVLLSSGSRTDE HCHHHHHCCCCCCCC		22006019
198	Phosphorylation	HRDVLLSSGSRTDEH CHHHHHCCCCCCCCC		25338131
200	Phosphorylation	DVLLSSGSRTDEHGN HHHHCCCCCCCCCCC		25338131
202	Phosphorylation	LLSSGSRTDEHGNQE HHCCCCCCCCCCCCC		25338131
252	Phosphorylation	EGEGAVLSPSQKPHI CCCCCEECCCCCCCC		25266776
254	Phosphorylation	EGAVLSPSQKPHICD CCCEECCCCCCCCCC		26643407
289	Phosphorylation	GERPFQCSQCSMGFI CCCCCCCCCCCHHHH		26745281
292	Phosphorylation	PFQCSQCSMGFIQKY CCCCCCCCHHHHHHH		26745281
337	Phosphorylation	ERHKRTHSGEKPYKC HHHCCCCCCCCCCCC		25266776
392	Phosphorylation	MGNLAVLSQGNTSSS CCCEEEEECCCCCCC		-
446	Phosphorylation	PTVSTSGSIIGTGID CCEECCCCCCCCCHH		29899451
481	Phosphorylation	KSYLNFVSPLPDVVG HHHHCCCCCCCCCCC		29514104
596	Ubiquitination	EIKSCHDKSGIPDEV HHHHCHHCCCCCHHH		22790023
596	Ubiquitination	EIKSCHDKSGIPDEV HHHHCHHCCCCCHHH		22790023
614	Ubiquitination	ILDQYSGKSETQKED HHHHCCCCCCCCCCC		-
619	Ubiquitination	SGKSETQKEDPFNLT CCCCCCCCCCCCCCC		22790023
619	Ubiquitination	SGKSETQKEDPFNLT CCCCCCCCCCCCCCC		22790023
639	Phosphorylation	LHTSGEHSELVQEEN CCCCCCCHHHHHHCC		18846507
648	Phosphorylation	LVQEENLSPGTQTPS HHHHCCCCCCCCCCC		26824392
651	Phosphorylation	EENLSPGTQTPSNDK HCCCCCCCCCCCCCH		27742792
653	Phosphorylation	NLSPGTQTPSNDKTS CCCCCCCCCCCCHHH		27742792
655	Phosphorylation	SPGTQTPSNDKTSML CCCCCCCCCCHHHHH		28066266
658	Ubiquitination	TQTPSNDKTSMLQEY CCCCCCCHHHHHHHH		22790023
658	Ubiquitination	TQTPSNDKTSMLQEY CCCCCCCHHHHHHHH		22790023
691	O-linked_Glycosylation	GHGFQFVSLSSPLHN CCCCEEEECCCCCCC		28528544
782	Phosphorylation	SSAFQSSSQKLTSQK HHHHHHHHHHHHCHH		25338131
784	Ubiquitination	AFQSSSQKLTSQKEQ HHHHHHHHHHCHHHH		22790023
784	Ubiquitination	AFQSSSQKLTSQKEQ HHHHHHHHHHCHHHH		22790023
805	Phosphorylation	STSFQIPSQELASQI CCCCCCCHHHHHHCC		25338131
838	Ubiquitination	QAFGSQFKSGSRVPM HHHHHCCCCCCCCCE		22790023
838	Ubiquitination	QAFGSQFKSGSRVPM HHHHHCCCCCCCCCE		22790023
846	Phosphorylation	SGSRVPMTFITNSNG CCCCCCEEEEECCCC		28285833
862	Phosphorylation	VDHRVRTSVSDFSGY EEEEEECCHHHHCCC		25266776
886	Phosphorylation	PCSTRVKTPTSQSYR CCCCCCCCCCCCCCC		25266776
888	O-linked_Glycosylation	STRVKTPTSQSYR-- CCCCCCCCCCCCC--		51588587
888	Phosphorylation	STRVKTPTSQSYR-- CCCCCCCCCCCCC--		21183079
889	O-linked_Glycosylation	TRVKTPTSQSYR--- CCCCCCCCCCCC---		28528544
889	Phosphorylation	TRVKTPTSQSYR--- CCCCCCCCCCCC---		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN281_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN281_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN281_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EWS_MOUSE	Ewsr1	physical	17093407
CDK1_MOUSE	Cdk1	physical	17093407
REQU_MOUSE	Dpf2	physical	17093407
SALL4_MOUSE	Sall4	physical	17093407
RIF1_MOUSE	Rif1	physical	17093407
NANOG_MOUSE	Nanog	physical	17093407

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.