TREF1_MOUSE - dbPTM
TREF1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TREF1_MOUSE
UniProt AC Q8BXJ2
Protein Name Transcriptional-regulating factor 1
Gene Name Trerf1
Organism Mus musculus (Mouse).
Sequence Length 1205
Subcellular Localization Nucleus .
Protein Description Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1..
Protein Sequence MGDQQLYKTNHVGHGGENLFYQQPPLGVHSGLGHSYGNTISGAGMDAPQASPISPHFPQDTRDGLGLPIGSKNLGQMDTSRQGGWGSHAGPGNHVQLRSNLANSNMMWGTPTQVEPADGYQYTYSQASEIRTQKLTSGVLHKLDSFTQVFANQNLRIQVNNMAQVLHTQSAVMDGASDSALRQLLSQKPVEPSASAIASRYQQVPQQPHPGFTGGLPKPALPVGQHAPQGHLYYDYQQPLAQMSMQGGQPLQAPQVLSGHMQQLQQHQYYPQPPPQQQQAGLQRISVQEMQQQQQPQQIRPSPPQQQQQLQLQQRQSSLQIPQYYQPQPMMQHLQEQQQPSMHLQPPSYHRDPHQYTPEQAHAVQLIQLGSMPQYYYQEPQQAYSHPLYPQSHLSQHQQREDGQLKTYSSDRQTPAMLSSHGDMGTSDTGVADPASSEMTRVTSTLPHQPLLSPSGIHLNNMGSQHQQPPSPSAMWPQMHLPDGRAQSGSPESSSGQTKGVFGEQFDAKNKLTCSICLKEFKSLPALNGHMRSHGGMRASPSLKQEEGEKAPPPQPQPQPQPQQPLPPPPPPPPPPQLPPEAERLTPMVMPVSVPVKLIPPKPSSQGFTNSVAATPAARDKPASSMSDDEMPVLEIPRKHPPIAAKVEEPLKNLPEKKKFRHRPEPLFIPPPPSSYTPNPTSYSGATLYQSQLRSPRILGDHLLLDPAHELPPYTPPPMLSPVRQGSGLFSNVLISGHGPGVHPQLPLTPLTPTPRVLLCRSSSIDGSNVTVTPGPGEQTVDVEPRINIGLRFQAEIPELQDVSALAQDTHRATLVWKPWPELENQALQQQVENLLNLCCSSALPGGGTNSEFALHSLFEAKGDVMATLEMLLLRKPVRLKCHPLANYHYAGSDKWTSLERKLFNKALATYSKDFIFVQKMVKSKTVAQCVEYYYTWKKIMRLGRKHRTRLAEIIDDCMTSEEEEEAEEEEEDPEEDRKSIKEEESEVAKSPEPPPAPALAPTEGPPMQAVGQQPSGNFICEMPNCGAVFSSRQALNGHARIHGGTNQVAKTRGAIPSGKQKPGGTQSGYCSVKSSPSHSTTSGETDPTTIFPCKECGKVFFKIKSRNAHMKTHRQQEEQQRQKAQKAAFAAEMAATIERTTGPVGAPELLPLDQLSLMKPVKDVDILDDDVVQQLGVMDEAEVVGTDLLLDDQDSVLLQGDTEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51PhosphorylationGMDAPQASPISPHFP
CCCCCCCCCCCCCCC		19.9525338131
54PhosphorylationAPQASPISPHFPQDT
CCCCCCCCCCCCCCC		18.7325338131
145PhosphorylationGVLHKLDSFTQVFAN
HHHHHHHHHHHHHCC		40.4022817900
147PhosphorylationLHKLDSFTQVFANQN
HHHHHHHHHHHCCCC		27.9820415495
188AcetylationLRQLLSQKPVEPSAS
HHHHHCCCCCCCCHH		47.8822826441
286PhosphorylationQAGLQRISVQEMQQQ
HHHHHHHCHHHHHHH		21.6729514104
302PhosphorylationQPQQIRPSPPQQQQQ
CCCCCCCCCHHHHHH		39.0926745281
407PhosphorylationREDGQLKTYSSDRQT
CCCCCCCCCCCCCCC		36.9126643407
408PhosphorylationEDGQLKTYSSDRQTP
CCCCCCCCCCCCCCC		12.4626643407
409PhosphorylationDGQLKTYSSDRQTPA
CCCCCCCCCCCCCCH		30.8726643407
410PhosphorylationGQLKTYSSDRQTPAM
CCCCCCCCCCCCCHH		26.8026643407
414PhosphorylationTYSSDRQTPAMLSSH
CCCCCCCCCHHHHCC		17.5726643407
419PhosphorylationRQTPAMLSSHGDMGT
CCCCHHHHCCCCCCC		13.7526643407
420PhosphorylationQTPAMLSSHGDMGTS
CCCHHHHCCCCCCCC		27.7726643407
426PhosphorylationSSHGDMGTSDTGVAD
HCCCCCCCCCCCCCC		19.4526643407
427PhosphorylationSHGDMGTSDTGVADP
CCCCCCCCCCCCCCC		27.6926643407
429PhosphorylationGDMGTSDTGVADPAS
CCCCCCCCCCCCCCC		33.0726643407
453PhosphorylationLPHQPLLSPSGIHLN
CCCCCCCCCCCEECC		25.3829514104
464PhosphorylationIHLNNMGSQHQQPPS
EECCCCCCCCCCCCC		17.4529514104
471PhosphorylationSQHQQPPSPSAMWPQ
CCCCCCCCCCCCCCC		37.8629514104
488PhosphorylationLPDGRAQSGSPESSS
CCCCCCCCCCCCCCC		40.0129550500
488 (in isoform 4)Phosphorylation-40.0128285833
488 (in isoform 3)Phosphorylation-40.0128285833
490 (in isoform 4)Phosphorylation-30.6427841257
490 (in isoform 3)Phosphorylation-30.6427841257
490PhosphorylationDGRAQSGSPESSSGQ
CCCCCCCCCCCCCCC		30.6427087446
493PhosphorylationAQSGSPESSSGQTKG
CCCCCCCCCCCCCCC		32.9429550500
540PhosphorylationSHGGMRASPSLKQEE
CCCCCCCCCCCCHHC		12.5029514104
624 (in isoform 2)Phosphorylation-34.7926643407
624PhosphorylationAARDKPASSMSDDEM
HHCCCCCCCCCCCCC		34.7926643407
625 (in isoform 2)Phosphorylation-25.1426643407
625PhosphorylationARDKPASSMSDDEMP
HCCCCCCCCCCCCCC		25.1426643407
627PhosphorylationDKPASSMSDDEMPVL
CCCCCCCCCCCCCEE		43.8126643407
627 (in isoform 2)Phosphorylation-43.8126643407
638 (in isoform 2)Phosphorylation-56.4226643407
639AcetylationPVLEIPRKHPPIAAK
CEEECCCCCCCCCHH		55.9223806337
640 (in isoform 2)Phosphorylation-34.3525263469
644 (in isoform 2)Phosphorylation-13.6530635358
646AcetylationKHPPIAAKVEEPLKN
CCCCCCHHCCHHHHC		40.9523806337
674PhosphorylationLFIPPPPSSYTPNPT
CCCCCCCCCCCCCCC		41.5725777480
675PhosphorylationFIPPPPSSYTPNPTS
CCCCCCCCCCCCCCC		38.5125777480
676PhosphorylationIPPPPSSYTPNPTSY
CCCCCCCCCCCCCCC		30.4725777480
677PhosphorylationPPPPSSYTPNPTSYS
CCCCCCCCCCCCCCC		20.6626643407
681PhosphorylationSSYTPNPTSYSGATL
CCCCCCCCCCCCCEE		47.1126643407
682PhosphorylationSYTPNPTSYSGATLY
CCCCCCCCCCCCEEE		20.6826643407
683PhosphorylationYTPNPTSYSGATLYQ
CCCCCCCCCCCEEEH		17.3825777480
684PhosphorylationTPNPTSYSGATLYQS
CCCCCCCCCCEEEHH		23.0125777480
687PhosphorylationPTSYSGATLYQSQLR
CCCCCCCEEEHHHCC		29.5325777480
689PhosphorylationSYSGATLYQSQLRSP
CCCCCEEEHHHCCCC		11.1925777480
691PhosphorylationSGATLYQSQLRSPRI
CCCEEEHHHCCCCCC		20.0225777480
695PhosphorylationLYQSQLRSPRILGDH
EEHHHCCCCCCCCCC		27.4225777480
714PhosphorylationPAHELPPYTPPPMLS
CHHCCCCCCCCCCCC		29.9125168779
715PhosphorylationAHELPPYTPPPMLSP
HHCCCCCCCCCCCCC		34.7822006019
721PhosphorylationYTPPPMLSPVRQGSG
CCCCCCCCCCCCCCC		18.3326643407
749PhosphorylationVHPQLPLTPLTPTPR
CCCCCCCCCCCCCCE		17.8222006019
752PhosphorylationQLPLTPLTPTPRVLL
CCCCCCCCCCCEEEE		26.7322006019
762PhosphorylationPRVLLCRSSSIDGSN
CEEEEEECCCCCCCC		27.6925619855
763PhosphorylationRVLLCRSSSIDGSNV
EEEEEECCCCCCCCE		16.3825619855
764PhosphorylationVLLCRSSSIDGSNVT
EEEEECCCCCCCCEE		26.4125619855
768PhosphorylationRSSSIDGSNVTVTPG
ECCCCCCCCEEECCC		25.1225619855
771PhosphorylationSIDGSNVTVTPGPGE
CCCCCCEEECCCCCC		23.9425619855
773PhosphorylationDGSNVTVTPGPGEQT
CCCCEEECCCCCCCE		17.1121082442
780PhosphorylationTPGPGEQTVDVEPRI
CCCCCCCEEECCCCC		17.8625619855
960PhosphorylationEIIDDCMTSEEEEEA
HHHHHHCCCHHHHHH		39.0429899451
961PhosphorylationIIDDCMTSEEEEEAE
HHHHHCCCHHHHHHH		19.0029899451
980PhosphorylationDPEEDRKSIKEEESE
CCHHHHHHHHHHHHH		39.5222817900
1075PhosphorylationSGYCSVKSSPSHSTT
CCEEEEECCCCCCCC		45.3826643407
1076PhosphorylationGYCSVKSSPSHSTTS
CEEEEECCCCCCCCC		25.3826643407
1078PhosphorylationCSVKSSPSHSTTSGE
EEEECCCCCCCCCCC		31.8326643407
1080PhosphorylationVKSSPSHSTTSGETD
EECCCCCCCCCCCCC		37.4025777480
1081PhosphorylationKSSPSHSTTSGETDP
ECCCCCCCCCCCCCC		21.4025777480
1082PhosphorylationSSPSHSTTSGETDPT
CCCCCCCCCCCCCCC		37.4425777480
1083PhosphorylationSPSHSTTSGETDPTT
CCCCCCCCCCCCCCC		34.4223375375
1086PhosphorylationHSTTSGETDPTTIFP
CCCCCCCCCCCCEEE		51.2925777480
1160AcetylationLDQLSLMKPVKDVDI
HHHHHCCCCCCCCCC		52.5323236377
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TREF1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TREF1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TREF1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TREF1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TREF1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-980, AND MASSSPECTROMETRY.

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