KAT7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAT7_MOUSE
• UniProt AC: Q5SVQ0
• Protein Name: Histone acetyltransferase KAT7
• Gene Name: Kat7
• Organism: Mus musculus (Mouse).
• Sequence Length: 613
• Subcellular Localization: Nucleus, nucleoplasm . Cytoplasm, cytosol . Nucleus . Associates with replication origins specifically during the G1 phase of the cell cycle.
• Protein Description: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation. [PubMed: 23319590 Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1. Specifically represses AR-mediated transcription.]
• Protein Sequence: MAIGVVKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVRNLPSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	VVKRNAGSSSDGTED EEECCCCCCCCCCCC	25.02	26643407
13	Phosphorylation	VKRNAGSSSDGTEDS EECCCCCCCCCCCCC	31.37	22668510
14	Phosphorylation	KRNAGSSSDGTEDSD ECCCCCCCCCCCCCC	41.58	25293948
17	Phosphorylation	AGSSSDGTEDSDFST CCCCCCCCCCCCCCC	41.43	25293948
20	Phosphorylation	SSDGTEDSDFSTDLE CCCCCCCCCCCCCCC	34.03	26643407
23	Phosphorylation	GTEDSDFSTDLEHTD CCCCCCCCCCCCCCC	26.46	19060867
41	Phosphorylation	SDGTSRRSARVTRSS CCCCCHHHHEEEHHH	21.22	22817900
45	Phosphorylation	SRRSARVTRSSARLS CHHHHEEEHHHHHHH	21.20	22817900
47	Phosphorylation	RSARVTRSSARLSQS HHHEEEHHHHHHHCC	20.98	25619855
48	Phosphorylation	SARVTRSSARLSQSS HHEEEHHHHHHHCCC	17.70	25619855
52	Phosphorylation	TRSSARLSQSSQDSS EHHHHHHHCCCCCCC	23.59	25521595
54	Phosphorylation	SSARLSQSSQDSSPV HHHHHHCCCCCCCCC	26.96	22942356
55	Phosphorylation	SARLSQSSQDSSPVR HHHHHCCCCCCCCCC	30.30	25521595
58	Phosphorylation	LSQSSQDSSPVRNLP HHCCCCCCCCCCCCC	28.98	25521595
59	Phosphorylation	SQSSQDSSPVRNLPS HCCCCCCCCCCCCCC	35.39	25521595
65 (in isoform 5)	Phosphorylation	-	31.03	29514104
66	Phosphorylation	SPVRNLPSFGTEEPA CCCCCCCCCCCCCCC	39.20	26745281
69 (in isoform 5)	Phosphorylation	-	34.85	29514104
69	Phosphorylation	RNLPSFGTEEPAYST CCCCCCCCCCCCCCC	34.85	26745281
74	Phosphorylation	FGTEEPAYSTRRVTR CCCCCCCCCCCCCCC	22.69	23984901
75	Phosphorylation	GTEEPAYSTRRVTRS CCCCCCCCCCCCCCC	19.97	28066266
76	Phosphorylation	TEEPAYSTRRVTRSQ CCCCCCCCCCCCCCC	15.15	23984901
82	Phosphorylation	STRRVTRSQQQPTPV CCCCCCCCCCCCCCC	23.99	25159016
87	Phosphorylation	TRSQQQPTPVTPKKY CCCCCCCCCCCCCCC	26.50	27149854
90	Phosphorylation	QQQPTPVTPKKYPLR CCCCCCCCCCCCCCC	30.51	25521595
99	Phosphorylation	KKYPLRQTRSSGSET CCCCCCCCCCCCCCC	26.53	21149613
101	Phosphorylation	YPLRQTRSSGSETEQ CCCCCCCCCCCCCEE	42.30	25521595
102	Phosphorylation	PLRQTRSSGSETEQV CCCCCCCCCCCCEEE	42.94	25521595
104	Phosphorylation	RQTRSSGSETEQVVD CCCCCCCCCCEEEEE	43.20	25521595
106	Phosphorylation	TRSSGSETEQVVDFS CCCCCCCCEEEEECC	33.15	27742792
113	Phosphorylation	TEQVVDFSDRETKNT CEEEEECCHHCCCCC	31.15	23684622
117	Phosphorylation	VDFSDRETKNTADHD EECCHHCCCCCCCCC	30.41	26643407
120	Phosphorylation	SDRETKNTADHDESP CHHCCCCCCCCCCCC	34.71	23684622
126	Phosphorylation	NTADHDESPPRTPTG CCCCCCCCCCCCCCC	46.38	27087446
130	Phosphorylation	HDESPPRTPTGNAPS CCCCCCCCCCCCCCC	30.86	27087446
132	Phosphorylation	ESPPRTPTGNAPSSE CCCCCCCCCCCCCCC	42.32	27087446
137	Phosphorylation	TPTGNAPSSESDIDI CCCCCCCCCCCCCCC	44.31	27087446
138	Phosphorylation	PTGNAPSSESDIDIS CCCCCCCCCCCCCCC	39.81	27087446
140	Phosphorylation	GNAPSSESDIDISSP CCCCCCCCCCCCCCC	41.64	27087446
145	Phosphorylation	SESDIDISSPNVSHD CCCCCCCCCCCCCCC	35.67	26160508
146	Phosphorylation	ESDIDISSPNVSHDE CCCCCCCCCCCCCCH	22.34	29472430
150	Phosphorylation	DISSPNVSHDESIAK CCCCCCCCCCHHHHH	31.68	25777480
154	Phosphorylation	PNVSHDESIAKDMSL CCCCCCHHHHHCCCC	33.62	21183079
157	Acetylation	SHDESIAKDMSLKDS CCCHHHHHCCCCCCC	52.90	22826441
160	Phosphorylation	ESIAKDMSLKDSGSD HHHHHCCCCCCCCCC	42.26	25159016
164	Phosphorylation	KDMSLKDSGSDLSHR HCCCCCCCCCCCCCC	38.31	26824392
166	Phosphorylation	MSLKDSGSDLSHRPK CCCCCCCCCCCCCCH	39.05	26824392
169	Phosphorylation	KDSGSDLSHRPKRRR CCCCCCCCCCCHHHC	23.57	25159016
173	Acetylation	SDLSHRPKRRRFHES CCCCCCCHHHCCHHH	59.50	133245
180	Phosphorylation	KRRRFHESYNFNMKC HHHCCHHHHCCCCCC	19.46	22817900
201	Acetylation	SLGHLTGKHERHFSI CHHHCCCCCCCCEEE	36.74	23806337
207	Phosphorylation	GKHERHFSISGCPLY CCCCCCEEEECCCCC	15.10	25266776
209	Phosphorylation	HERHFSISGCPLYHN CCCCEEEECCCCCCC	32.90	23984901
214	Phosphorylation	SISGCPLYHNLSADE EEECCCCCCCCCHHH	3.62	23984901
218	Phosphorylation	CPLYHNLSADECKVR CCCCCCCCHHHHHHH	38.70	26643407
223	Acetylation	NLSADECKVRAQSRD CCCHHHHHHHHHHHH	32.48	22826441
275	Phosphorylation	ELRKKRNSGLSKEQK HHHHHHHCCCCHHHH	45.18	23737553
278	Phosphorylation	KKRNSGLSKEQKEKY HHHHCCCCHHHHHHH	37.36	23737553
279	Acetylation	KRNSGLSKEQKEKYM HHHCCCCHHHHHHHH	70.02	23806337
405	Phosphorylation	DEIYRKGSISVFEVD CHHCCCCCEEEEEEC	18.09	28066266
407	Phosphorylation	IYRKGSISVFEVDGK HCCCCCEEEEEECCC	23.58	28066266
434	Acetylation	AKLFLDHKTLYYDVE HHHHCCCCCEECCCH	39.63	-
437	Phosphorylation	FLDHKTLYYDVEPFL HCCCCCEECCCHHHE	11.67	-
508	Phosphorylation	KVEEKVGSPERPLSD HHHHHHCCCCCCHHH	26.95	26643407
608	Phosphorylation	DPSCLKWTPPKGT-- CHHHHCCCCCCCC--	28.29	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAT7_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
52	S	Phosphorylation	Phosphorylated at Ser-52 and Ser-55 by ATR in response to DNA damage, promoting its ubiquitination by the CRL4(DDB2) complex and subsequent degradation.	21183079
52	S	Phosphorylation	Phosphorylation at Ser-52 and Ser-55 by ATR in response to ultraviolet-induced DNA, promotes localization to DNA damage sites.	21183079
52	S	ubiquitylation	Phosphorylated at Ser-52 and Ser-55 by ATR in response to DNA damage, promoting its ubiquitination by the CRL4(DDB2) complex and subsequent degradation.	21183079
55	S	Phosphorylation	Phosphorylated at Ser-52 and Ser-55 by ATR in response to DNA damage, promoting its ubiquitination by the CRL4(DDB2) complex and subsequent degradation.	23319590
55	S	Phosphorylation	Phosphorylation at Ser-52 and Ser-55 by ATR in response to ultraviolet-induced DNA, promotes localization to DNA damage sites.	23319590
55	S	ubiquitylation	Phosphorylated at Ser-52 and Ser-55 by ATR in response to DNA damage, promoting its ubiquitination by the CRL4(DDB2) complex and subsequent degradation.	23319590
59	S	Phosphorylation	Phosphorylation at Ser-59 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-87 and Thr-90 by CDK1 (By similarity).	21183079
87	T	Phosphorylation	Phosphorylation at Ser-59 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-87 and Thr-90 by CDK1 (By similarity).	21183079
90	T	Phosphorylation	Phosphorylation at Ser-59 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-87 and Thr-90 by CDK1 (By similarity).	21183079
340	K	ubiquitylation	Ubiquitinated at Lys-340, leading to proteasomal degradation.	-
434	K	Acetylation	Autoacetylation at Lys-434 is required for proper function.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAT7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KAT7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.