PHC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHC1_MOUSE
• UniProt AC: Q64028
• Protein Name: Polyhomeotic-like protein 1
• Gene Name: Phc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1012
• Subcellular Localization: Nucleus.
• Protein Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression (By similarity)..
• Protein Sequence: METESEQNSSSTNGSSSSGASSRPQIAQMSLYERQAVQALQALQRQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAASRQASSPNSSTAQQQTATTQASMNLATTSAAQLISRSQSVSSPSATTLTQSVLLGNTTSPPLNQSQAQMYLRPQLGNLLQVNRTLGRNVPLASQLILMPNGAVAAVQQEVPPAQSPGVHADADQVQNLAVRNQQASAQGPQMPGSTQKAIPPGASPVSGLSQTSSQALAVAQASSGASGQSLNLSQAGGGSGNSLPGSMGPGGGGQAPGGLGQLPSSGLTGGSCPRKGTGVVQPLPAAQTVTVSQGSQTEAESAAAKKAEADGSGQQSVGMNLTRTATPAPSQTLISSATYTQIQPHSLIQQQQQIHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQQQQQQQQQQQQQQQQQQQQQQGTTLTAPQPPQVPPTQQVPPSQSQQQAQTLVVQPMLQSSPLTLPPEPTSKPPIPIQSKPPVAPIKPPQLGAAKMSATQQPPPHIPVQVVGTRQPGSAQAQALGLAQLAAAVPTPRGITGAVQPGQAHLASSPPSSQAAPGALQECPPALAAGMTLAPVQGTAHVVKGGPTASSPVVAQVPAAFYMQSVHLPGKAQTLAVKRKAESEEERDDLSALASVLPTKASPAAESPKVIEEKNSLGEKAEPVASLNANPPNSDLVALAPTPSAPPPTLALVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQFLKETEKPLQAGLPTGLNESQPSGPLGGDSPSVELEKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEFQEASYARVRRRGPRRSSSDIARAKIQGKRHRGQEDSSRGSDNSSYDEALSPTSPGPLSVRAGHGERDLGNTITTPSTPELQGINPVFLSSNPSQWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINVLKET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
274	Phosphorylation	AGGGSGNSLPGSMGP CCCCCCCCCCCCCCC	39.19	-
278	Phosphorylation	SGNSLPGSMGPGGGG CCCCCCCCCCCCCCC	20.73	-
618	Phosphorylation	HVVKGGPTASSPVVA EEECCCCCCCCCEEE	42.31	26643407
620	Phosphorylation	VKGGPTASSPVVAQV ECCCCCCCCCEEECC	37.34	26745281
621	Phosphorylation	KGGPTASSPVVAQVP CCCCCCCCCEEECCC	21.17	26745281
653	Phosphorylation	AVKRKAESEEERDDL HHHHHCCCHHHHHHH	55.99	25619855
661	Phosphorylation	EEERDDLSALASVLP HHHHHHHHHHHHHCC	28.38	28066266
665	Phosphorylation	DDLSALASVLPTKAS HHHHHHHHHCCCCCC	25.66	25619855
669	Phosphorylation	ALASVLPTKASPAAE HHHHHCCCCCCCCCC	34.77	25619855
677	Phosphorylation	KASPAAESPKVIEEK CCCCCCCCCHHHHHC	25.87	29895711
794	Phosphorylation	SGPLGGDSPSVELEK CCCCCCCCCCCHHHH	23.50	21149613
796	Phosphorylation	PLGGDSPSVELEKKA CCCCCCCCCHHHHHH	31.98	26160508
869	Phosphorylation	RRRGPRRSSSDIARA HHHCCCCCHHHHHHH	35.16	23684622
870	Phosphorylation	RRGPRRSSSDIARAK HHCCCCCHHHHHHHH	30.16	23684622
871	Phosphorylation	RGPRRSSSDIARAKI HCCCCCHHHHHHHHH	33.99	23684622
893	Phosphorylation	QEDSSRGSDNSSYDE CCCCCCCCCCCCCCC	32.29	29899451
896	Phosphorylation	SSRGSDNSSYDEALS CCCCCCCCCCCCCCC	34.95	29899451
897	Phosphorylation	SRGSDNSSYDEALSP CCCCCCCCCCCCCCC	42.74	29899451
903	Phosphorylation	SSYDEALSPTSPGPL CCCCCCCCCCCCCCC	32.93	22006019
905	Phosphorylation	YDEALSPTSPGPLSV CCCCCCCCCCCCCEE	44.15	27717184
906	Phosphorylation	DEALSPTSPGPLSVR CCCCCCCCCCCCEEE	31.10	22006019
930	Phosphorylation	NTITTPSTPELQGIN CCEECCCCHHHCCCC	23.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCMH1_MOUSE	Scmh1	physical	10653359
PHC2_MOUSE	Phc2	physical	16024804
BMI1_MOUSE	Bmi1	physical	9571155
CBX2_MOUSE	Cbx2	physical	9571155
RING2_MOUSE	Rnf2	physical	15741318
RING2_MOUSE	Rnf2	physical	12183370

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.