CBX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBX2_MOUSE
• UniProt AC: P30658
• Protein Name: Chromobox protein homolog 2
• Gene Name: Cbx2
• Organism: Mus musculus (Mouse).
• Sequence Length: 519
• Subcellular Localization: Nucleus speckle . Chromosome . Localizes to the inactivated X chromosome in females.
• Protein Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). [PubMed: 16537902 Plays a role in the lineage differentiation of the germ layers in embryonic development]
• Protein Sequence: MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILDPRLLLAFQKKEHEKEVQNRKRGKRPRGRPRKHTVTSSCSRRSKLKEPDAPSKSKSSSSSSSSTSSSSSSDEEEDDSDLDSKRGPRGRETHPVPQKKAQILVAKPELKDPIRKKRGRKPLPPEQKAARRPVSLAKVLKTTRKDLGTSAAKLPPPLSAPVAGLAALKAHTKEACGGPSTMATPENLASLMKGMAGSPSRGGIWQSSIVHYMNRMSQSQVQAASRLALKAQATNKCGLGLDLKVRTQKGGELGGSPAGGKVPKAPGGGAAEQQRGNHSGSPGAQLAPTQELSLQVLDLQSVKNGVPGVGLLARHAPAKAIPATNPATGKGPGSGPTGANMTNAPTDNNKGEKLTCKATALPAPSVKRDTVKSVAASGGQEGHTAPGEGRKPPALSELSTGEENSSSDSDPDSTSLPSAAQNLSVAIQTSQDWKPTRSLIEHVFVTDVTANLITVTVKESPTSVGFFNLRHY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	PRKHTVTSSCSRRSK CCCCCCCCHHCCCHH	25.63	22871156
88	Phosphorylation	RKHTVTSSCSRRSKL CCCCCCCHHCCCHHC	13.52	22871156
167	Dimethylation	PIRKKRGRKPLPPEQ HHHHCCCCCCCCHHH	41.26	-
245	Phosphorylation	LMKGMAGSPSRGGIW HHHHHCCCCCCCCCC	15.34	27717184
248	Asymmetric dimethylarginine	GMAGSPSRGGIWQSS HHCCCCCCCCCCHHH	51.22	-
248	Methylation	GMAGSPSRGGIWQSS HHCCCCCCCCCCHHH	51.22	24129315
303	Phosphorylation	KGGELGGSPAGGKVP CCCCCCCCCCCCCCC	15.13	26824392
326	Phosphorylation	EQQRGNHSGSPGAQL HHCCCCCCCCCCCCC	44.99	26745281
328	Phosphorylation	QRGNHSGSPGAQLAP CCCCCCCCCCCCCCC	24.15	23984901
336	Phosphorylation	PGAQLAPTQELSLQV CCCCCCCCCCEEEEE	29.12	23984901
340	Phosphorylation	LAPTQELSLQVLDLQ CCCCCCEEEEEECHH	18.92	26745281
507	Phosphorylation	ITVTVKESPTSVGFF EEEEECCCCCEEECE	27.97	28066266
509	Phosphorylation	VTVKESPTSVGFFNL EEECCCCCEEECEEC	45.37	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBX2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBX2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBX2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHC1_HUMAN	PHC1	physical	12167701
BMI1_HUMAN	BMI1	physical	12167701
RING1_HUMAN	RING1	physical	12167701
CBX4_HUMAN	CBX4	physical	12167701
PHC3_HUMAN	PHC3	physical	12167701
SMCA5_HUMAN	SMARCA5	physical	12167701
SCMH1_HUMAN	SCMH1	physical	12167701
HSP74_HUMAN	HSPA4	physical	12167701
PHC2_HUMAN	PHC2	physical	12167701
BMI1_MOUSE	Bmi1	physical	9571155
PHC1_MOUSE	Phc1	physical	9571155
RING1_MOUSE	Ring1	physical	9312051
H33_MOUSE	H3f3a	physical	20493168
NRAM1_MOUSE	Slc11a1	physical	17726103

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.