NRAM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRAM1_MOUSE
• UniProt AC: P41251
• Protein Name: Natural resistance-associated macrophage protein 1
• Gene Name: Slc11a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 548
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes..
• Protein Sequence: MISDKSPPRLSRPSYGSISSLPGPAPQPAPCRETYLSEKIPIPSADQGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTIELAIVGSDMQEVIGTAISFNLLSAGRIPLWDGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVAHPSQGALLKGLVLPTCPGCGQPELLQAVGIVGAIIMPHNIYLHSALVKSREVDRTRRVDVREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQQTNEEAFNICANSSLQNYAKIFPRDNNTVSVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRWSRFARVLLTRSCAILPTVLVAVFRDLKDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPAVMQEFANGRMSKAITSCIMALVCAINLYFVISYLPSLPHPAYFGLVALFAIGYLGLTAYLAWTCCIAHGATFLTHSSHKHFLYGLPNEEQGGVQGSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MISDKSPPRL -----CCCCCCCCCC	37.37	24719451
6	Phosphorylation	--MISDKSPPRLSRP --CCCCCCCCCCCCC	45.16	29472430
11	Phosphorylation	DKSPPRLSRPSYGSI CCCCCCCCCCCCCCC	43.34	25159016
14	Phosphorylation	PPRLSRPSYGSISSL CCCCCCCCCCCCCCC	40.80	22942356
15	Phosphorylation	PRLSRPSYGSISSLP CCCCCCCCCCCCCCC	19.99	25159016
17	Phosphorylation	LSRPSYGSISSLPGP CCCCCCCCCCCCCCC	15.86	25159016
19	Phosphorylation	RPSYGSISSLPGPAP CCCCCCCCCCCCCCC	27.76	25159016
20	Phosphorylation	PSYGSISSLPGPAPQ CCCCCCCCCCCCCCC	36.59	25159016
321	N-linked_Glycosylation	EAFNICANSSLQNYA HHHHHHHCHHHHHHH	27.93	-
335	N-linked_Glycosylation	AKIFPRDNNTVSVDI HHHCCCCCCEEEEEE	47.56	-
447	Phosphorylation	VLPILTFTSMPAVMQ HHHHHCCCCCHHHHH	20.91	-
448	Phosphorylation	LPILTFTSMPAVMQE HHHHCCCCCHHHHHH	20.69	-
547	Phosphorylation	EQGGVQGSG------ HHCCCCCCC------	25.00	20531401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRAM1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRAM1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRAM1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BMI1_MOUSE	Bmi1	physical	17726103
PCGF2_MOUSE	Pcgf2	physical	17726103
CBX2_MOUSE	Cbx2	physical	17726103

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.