PCGF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCGF2_MOUSE
• UniProt AC: P23798
• Protein Name: Polycomb group RING finger protein 2
• Gene Name: Pcgf2
• Organism: Mus musculus (Mouse).
• Sequence Length: 342
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor. [PubMed: 8521824 Binds specifically to the DNA sequence 5'-GACTNGACT-3']
• Protein Sequence: MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQEKGALGDDEIVSLSIEFYEGVRDREEKKNLTENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEILYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLPTVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSPTPPSTAAGTTTATNGGTSNCLQTPSSTSRGRKMTVNGAPCPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	Phosphorylation	LTEVPNGSNEDRGEV CCCCCCCCCCCHHHH	43.62	22817900
132	Phosphorylation	LGDDEIVSLSIEFYE CCCCEEEEEEEEEHH	23.28	22817900
151	Phosphorylation	REEKKNLTENGDGDK HHHHHCCCCCCCCCH	36.48	27180971
237	Phosphorylation	QPACKRLTLPTVPTP CCCCCCCCCCCCCCC	34.42	-
251	Phosphorylation	PSEGTNTSGASECES CCCCCCCCCCCCCEE	34.14	25195567
254	Phosphorylation	GTNTSGASECESVSD CCCCCCCCCCEECCC	46.43	22817900
258	Phosphorylation	SGASECESVSDKAPS CCCCCCEECCCCCCC	38.28	22817900
260	Phosphorylation	ASECESVSDKAPSPA CCCCEECCCCCCCCC	42.55	22817900
265	Phosphorylation	SVSDKAPSPATLPAT ECCCCCCCCCCCCCC	31.84	22817900
278	Phosphorylation	ATSSSLPSPATPSHG CCCCCCCCCCCCCCC	32.24	22817900
281	Phosphorylation	SSLPSPATPSHGSPS CCCCCCCCCCCCCCC	28.80	22817900
286	Phosphorylation	PATPSHGSPSSHGPP CCCCCCCCCCCCCCC	19.04	22817900
299	Phosphorylation	PPATHPTSPTPPSTA CCCCCCCCCCCCCCC	31.09	22817900
334	Phosphorylation	TSRGRKMTVNGAPCP CCCCCEEEECCCCCC	17.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
237	T	Phosphorylation	Kinase	PKA	-	Uniprot
334	T	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCGF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCGF2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHC2_MOUSE	Phc2	physical	16024804
NRAM1_MOUSE	Slc11a1	physical	17726103
RING1_MOUSE	Ring1	physical	22325148
RING2_MOUSE	Rnf2	physical	22325148
RYBP_MOUSE	Rybp	physical	22325148
CBX7_MOUSE	Cbx7	physical	22325148
PHC2_MOUSE	Phc2	physical	12034499
RING2_MOUSE	Rnf2	physical	15741318
RING2_MOUSE	Rnf2	physical	12183370
PCGF2_MOUSE	Pcgf2	physical	12438698

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.