PHC2_MOUSE - dbPTM
PHC2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHC2_MOUSE
UniProt AC Q9QWH1
Protein Name Polyhomeotic-like protein 2
Gene Name Phc2
Organism Mus musculus (Mouse).
Sequence Length 850
Subcellular Localization Nucleus .
Protein Description Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility..
Protein Sequence MENELPVPHTSNRASVTTNTSGTNSSSGCISSSGGGGGSGGRPTAPQISVYSGIPDRQTVQVIQQALHRQPSTAAQYLQQMYAAQQQHLMLQTAALQQQHLSSAQLQSLAAVQQASLVANRQGSTPGSSVSSQAPAQSSSLNLAASPAAAQLINRAQSVNSAAASGLAQQAVLLGNTSSPALTASQAQMYLRAQMLIFTPTATVATVQPELCTGSPARPPTPAQVQNLTLRTQQTPAAAASGPPPTQPVLPSLALKPTPSSSQPLPAPPQGRTMAQGSPAGAKPSGTDNAPETLKAGDGNCNMEGRPGPGRAVPAVATHPLIAPAYAHLQSHQLLPQPPAKHPQPQFVAQQQPQPPRPAPQVQSQPQLASVSPSLALQSSPEDHALPLGSVTQALPLQCSTTHVHKPGNSQQCHLPTLDTGSQNGHPEGGSHPPQRRFQHTSAVILQVQPASPVTPQQCAPDDWKEVVPAEKSVPVARPGPSPHQQAIIPAIPGGLPGPKSPNIQQCPAHETGQGIVHALTDLSSPGMTSGNGNSASSIAGTAPQNGENKPPQAIVKPQILTHVIEGFVIQEGAEPFPVGRSSLLVGNLKKKYAQGFLPEKPPQQDHTTTTDSEMEEPYLQESKEEGTPLKLKCELCGRVDFAYKFKRSKRFCSMACAKRYNVGCTKRVGLFHSDRSKLQKAGTTTHNRRRASKASLPTLTKDTKKQPSGTVPLSVTAALQLAHSQEDSSRCSDNSSYEEPLSPISASSSTSRRRQGQRDLDLPDMHMRDLVGVGHHFLPSEPTKWNVEDVYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISMLKDS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
278PhosphorylationGRTMAQGSPAGAKPS
CCCCCCCCCCCCCCC		10.2527841257
482PhosphorylationPVARPGPSPHQQAII
CCCCCCCCHHHCCCC		40.7127841257
583PhosphorylationPFPVGRSSLLVGNLK
CCCCCCCCEEHHHHH		25.1027841257
593NitrationVGNLKKKYAQGFLPE
HHHHHHHHHCCCCCC		17.03-
593PhosphorylationVGNLKKKYAQGFLPE
HHHHHHHHHCCCCCC		17.0326643407
608PhosphorylationKPPQQDHTTTTDSEM
CCCCCCCCCCCCHHH		33.8427087446
609PhosphorylationPPQQDHTTTTDSEME
CCCCCCCCCCCHHHC		25.0327087446
610PhosphorylationPQQDHTTTTDSEMEE
CCCCCCCCCCHHHCC		29.7526643407
611PhosphorylationQQDHTTTTDSEMEEP
CCCCCCCCCHHHCCC		35.1227087446
613PhosphorylationDHTTTTDSEMEEPYL
CCCCCCCHHHCCCHH		36.4321659605
619PhosphorylationDSEMEEPYLQESKEE
CHHHCCCHHHCCCCC		25.0526643407
674PhosphorylationKRVGLFHSDRSKLQK
CCEECCCCCHHHHHH		27.6429176673
693PhosphorylationTHNRRRASKASLPTL
HHHHHHHHHCCCCCC		27.2629514104
696PhosphorylationRRRASKASLPTLTKD
HHHHHHCCCCCCCCC		38.3229514104
702AcetylationASLPTLTKDTKKQPS
CCCCCCCCCCCCCCC		67.5223806337
725PhosphorylationAALQLAHSQEDSSRC
HHHHHHHCCCCHHCC		29.6519854140
733PhosphorylationQEDSSRCSDNSSYEE
CCCHHCCCCCCCCCC		38.4230635358
736PhosphorylationSSRCSDNSSYEEPLS
HHCCCCCCCCCCCCC		39.0128066266
737PhosphorylationSRCSDNSSYEEPLSP
HCCCCCCCCCCCCCC		42.7028066266
738PhosphorylationRCSDNSSYEEPLSPI
CCCCCCCCCCCCCCC		24.9228066266
743PhosphorylationSSYEEPLSPISASSS
CCCCCCCCCCCCCHH		30.7925266776
746PhosphorylationEEPLSPISASSSTSR
CCCCCCCCCCHHHHH		26.0328066266
748PhosphorylationPLSPISASSSTSRRR
CCCCCCCCHHHHHHH		20.3128066266
749PhosphorylationLSPISASSSTSRRRQ
CCCCCCCHHHHHHHC		37.0328066266
750PhosphorylationSPISASSSTSRRRQG
CCCCCCHHHHHHHCC		28.1028066266
751PhosphorylationPISASSSTSRRRQGQ
CCCCCHHHHHHHCCC		28.3528066266
752PhosphorylationISASSSTSRRRQGQR
CCCCHHHHHHHCCCC		26.2428066266
785UbiquitinationFLPSEPTKWNVEDVY
CCCCCCCCCCHHHHH		47.70-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHC2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHC2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHC2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RING2_MOUSERnf2physical
16024804
PHC1_MOUSEPhc1physical
16024804
MAPK2_MOUSEMapkapk2physical
19369945
RING2_MOUSERnf2physical
12183370
RING1_MOUSERing1physical
12183370
BMI1_MOUSEBmi1physical
12183370
PCGF2_MOUSEPcgf2physical
12183370
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHC2_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory