SCMH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCMH1_MOUSE
• UniProt AC: Q8K214
• Protein Name: Polycomb protein SCMH1
• Gene Name: Scmh1 {ECO:0000312|MGI:MGI:1352762}
• Organism: Mus musculus (Mouse).
• Sequence Length: 706
• Subcellular Localization: Nucleus .
• Protein Description: Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes..
• Protein Sequence: MLVCYSVLACESLWDLPCSIMGSPLGHFTWDKYLKETCSVPAPVHCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIKIFHKEPPSPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGAEVLVTFDGWRGAFDYWCRFDSRDIFPVGWCSLTGDNLQPPGTKVVIPKNPSPSSDVSTEKPSIHSTKTVLEHQPGQRGRKPGKKRGRTPKILIPHPTSTPSKSAEPLKFPKKRGPKPGSKRKPRTLLSPPPTSPTTSTPEPDTSTVPQDAATVPSSAMQAPTVCIYLNKSGSTGPHLDKKKIQQLPDHFGPARASVVLQQAVQACIDCAYHQKTVFSFLKQGHGGEVISAVFDREQHTLNLPAVNSITYVLRFLEKLCHNLRSDNLFGNQPFTQTHLSLTATEYNHNHDRYLPGETFVLGNSLARSLETHSDLMDSALKPANLVSTSQNLRTPGYRPLLPSCGLPLSTVSAVRRLCSKGVLKGKKERRDVESFWKLNHSPGSDRHLESRDPPRLSGRDPSSWTVEDVMQFVREADPQLGSHADLFRKHEIDGKALLLLRSDMMMKYMGLKLGPALKLSFHIDRLKQVFWKRETILWSREGLSREVWPISEDTALGHFFSGMDKVFGSLSKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
143	Phosphorylation	WPMFLLKTLNGAEMA CCEEHHHHCCCCEEC	25.98	28059163
246	Phosphorylation	VVIPKNPSPSSDVST EEECCCCCCCCCCCC	46.97	22942356
249	Phosphorylation	PKNPSPSSDVSTEKP CCCCCCCCCCCCCCC	45.47	27841257
252	Phosphorylation	PSPSSDVSTEKPSIH CCCCCCCCCCCCCCC	35.52	27841257
253	Phosphorylation	SPSSDVSTEKPSIHS CCCCCCCCCCCCCCC	48.12	27841257
292	Phosphorylation	KILIPHPTSTPSKSA CEEECCCCCCCCCCC	42.05	26643407
293	Phosphorylation	ILIPHPTSTPSKSAE EEECCCCCCCCCCCC	42.65	26643407
294	Phosphorylation	LIPHPTSTPSKSAEP EECCCCCCCCCCCCC	33.78	26643407
296	Phosphorylation	PHPTSTPSKSAEPLK CCCCCCCCCCCCCCC	39.05	26643407
441	Phosphorylation	LNLPAVNSITYVLRF CCCCHHHHHHHHHHH	15.09	-
443	Phosphorylation	LPAVNSITYVLRFLE CCHHHHHHHHHHHHH	13.85	-
542	Phosphorylation	PSCGLPLSTVSAVRR CCCCCCHHHHHHHHH	25.48	21454597
545	Phosphorylation	GLPLSTVSAVRRLCS CCCHHHHHHHHHHHH	22.57	21454597
574	Phosphorylation	SFWKLNHSPGSDRHL HHHHHCCCCCCCCCC	29.86	24899341
577	Phosphorylation	KLNHSPGSDRHLESR HHCCCCCCCCCCCCC	34.55	27841257
588	Dimethylation	LESRDPPRLSGRDPS CCCCCCCCCCCCCCC	47.04	-
588	Methylation	LESRDPPRLSGRDPS CCCCCCCCCCCCCCC	47.04	18963939
592	Dimethylation	DPPRLSGRDPSSWTV CCCCCCCCCCCCCCH	49.65	-
592	Methylation	DPPRLSGRDPSSWTV CCCCCCCCCCCCCCH	49.65	18963949
672	Phosphorylation	KRETILWSREGLSRE HHCHHEEECCCCCCC	19.60	28059163
687	Phosphorylation	VWPISEDTALGHFFS EECCCCCHHHHHHHH	21.52	27566939

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCMH1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCMH1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCMH1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHC1_MOUSE	Phc1	physical	10653359
GEMI_MOUSE	Gmnn	physical	23207902
H2A2C_MOUSE	Hist2h2ac	physical	23207902

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.