GEMI_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GEMI_MOUSE
• UniProt AC: O88513
• Protein Name: Geminin
• Gene Name: Gmnn
• Organism: Mus musculus (Mouse).
• Sequence Length: 206
• Subcellular Localization: Cytoplasm. Nucleus. Mainly cytoplasmic but can be relocalized to the nucleus..
• Protein Description: Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.; Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control..
• Protein Sequence: MNLSMKQKQEGAQENVKNSPVPRRTLKMIQPSADGSLVGRENELPKGLFKRKLWDDQLASQTSSCGPEANENKDVGDLTQEAFDLISKENPSSQYWKEVAEQRRKALYEALKENEKLHKEIEQKDSEIARLRKENKDLAEVAEHVQYMAEVIERLSNEPLDNFESPDSQEFDSEEEAVEYSELEDSGAGTCAEETVSSSTDARPCT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	AQENVKNSPVPRRTL HHHHHCCCCCCHHHH	22.89	26824392
27	Acetylation	PVPRRTLKMIQPSAD CCCHHHHHHCCCCCC	33.09	-
36	Phosphorylation	IQPSADGSLVGRENE CCCCCCCCCCCCCCC	22.04	-
63	Phosphorylation	DQLASQTSSCGPEAN HHHHHCCCCCCCCCC	18.92	-
64	Phosphorylation	QLASQTSSCGPEANE HHHHCCCCCCCCCCC	26.87	-
181	Phosphorylation	EEEAVEYSELEDSGA HHHHHHHHHHCCCCC	23.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
181	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
181	S	Phosphorylation	Phosphorylation at Ser-181 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GEMI_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPA24_MOUSE	Spata24	physical	19515240
TBP_MOUSE	Tbp	physical	19515240
TBPL1_MOUSE	Tbpl1	physical	19515240
TF2B_MOUSE	Gtf2b	physical	19515240
HXA11_MOUSE	Hoxa11	physical	14973489
HXD10_MOUSE	Hoxd10	physical	14973489
SCMH1_MOUSE	Scmh1	physical	14973489
HXA7_MOUSE	Hoxa7	physical	14973489
HXB7_MOUSE	Hoxb7	physical	14973489
HXC8_MOUSE	Hoxc8	physical	14973489
HXC9_MOUSE	Hoxc9	physical	14973489
HXA10_MOUSE	Hoxa10	physical	14973489
PHC1_MOUSE	Phc1	physical	14973489
CDT1_MOUSE	Cdt1	physical	14973489
CDT1_MOUSE	Cdt1	physical	15286659
SCMH1_MOUSE	Scmh1	physical	23207902
CCNA2_HUMAN	CCNA2	physical	26496610
CKS1_HUMAN	CKS1B	physical	26496610
SKP2_HUMAN	SKP2	physical	26496610
CDT1_HUMAN	CDT1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.