| UniProt ID | TBP_MOUSE | |
|---|---|---|
| UniProt AC | P29037 | |
| Protein Name | TATA-box-binding protein | |
| Gene Name | Tbp | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 316 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.. | |
| Protein Sequence | MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQAVATAAASVQQSTSQQPTQGASGQTPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 310 | Ubiquitination | ENIYPILKGFRKTT- HHHHHHHHCCCCCC- | 57.64 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TBP_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TBP_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBP_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TAF13_MOUSE | Taf13 | physical | 20211142 | |
| SP3_MOUSE | Sp3 | physical | 21149256 | |
| NFYA_MOUSE | Nfya | physical | 21705419 | |
| TAF6_MOUSE | Taf6 | physical | 17242199 | |
| TAF7_MOUSE | Taf7 | physical | 17242199 | |
| TAF7L_MOUSE | Taf7l | physical | 17242199 | |
| TAF1A_MOUSE | Taf1a | physical | 9050847 | |
| TAF1B_MOUSE | Taf1b | physical | 9050847 | |
| TAF1C_MOUSE | Taf1c | physical | 9050847 | |
| TAF1A_HUMAN | TAF1A | physical | 9050847 | |
| TAF1B_HUMAN | TAF1B | physical | 9050847 | |
| TAF1C_HUMAN | TAF1C | physical | 9050847 | |
| NACAM_MOUSE | Naca | physical | 9488445 | |
| NACA_MOUSE | Naca | physical | 9488445 | |
| CAND2_RAT | Cand2 | physical | 10441524 | |
| TF2B_MOUSE | Gtf2b | physical | 8414971 | |
| PIAS3_MOUSE | Pias3 | physical | 16522640 | |
| TF2AA_MOUSE | Gtf2a1 | physical | 16522640 | |
| PIAS1_MOUSE | Pias1 | physical | 16522640 | |
| ZNF76_MOUSE | Zfp523 | physical | 16522640 | |
| TAF5_MOUSE | Taf5 | physical | 7744009 | |
| TAF10_MOUSE | Taf10 | physical | 7744009 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
