CAND2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAND2_RAT
• UniProt AC: Q9R0L4
• Protein Name: Cullin-associated NEDD8-dissociated protein 2
• Gene Name: Cand2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1273
• Subcellular Localization: Nucleus.
• Protein Description: Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes..
• Protein Sequence: MSTGAFYISSLLEKMTSSDKDFSPKSLGGSRVLDPLPWLQILAAITDWISGDRTQDLALPRFMATSDLMSELQKDSIQLDEDSERKVVRTLLRLLEDRSGEVQNLAVKCLGPLVGKVKEYQVENIVDTLCANMRSDKEQLRDIAGIGLKTVLSELPPAATGSGLAISVCRKITGQLTSAIAQQEDVAVQLEALDILSDMLSRLGAPLGTFHASLLHCLLPQLSSPRLAVRKRTVVALGHLAAACSTDLFVELADHLVDRLPGPRAPASPAAIRTLIQCLGSVGRQAGHRLGAHLDRLMPLVEEFCNLDDDELRESCLQAFEAFLRKCPKEMDPHVPNVTSLCLQYMKHDPNYNHDSDEEEQMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAKCMAALISSRPDLLPDFHCTLAPALIRCFKEREENVKADIFGAYIMLLRHTRPPKGWLEAVEEPTQTGRNLNMLRAQVPLVMKALQRQLKDRNVRTRQGCFNLFTELAGVLPGCLAEHMTVLVSGIVFSLADYSSSSTIRMDALAFLQGLLGTEPAEAFHPHLPTLLPPVMACVADPFYKVAAEALLVLQELVRTLWPLDRPRLLDPEPYVGEMSTATLARLRATDLDQEVKERAISCVGHLVGHLGDRLGDDLEPTLLLLLDRLRNEITRLPAVKALTLVAVSPLRLDLQPILAEALPILASFLRKNQRALRLATLAALDALAQSQGLGLPPPAVRSVLAELPALVSENDMHVAQLAVDFLTTVTQTQPASLVEVSGPVLEELLQLLHSPLLPAGVLAATEGFLQALVGTRPPCVEYSELISLLTAPVYNQVGDGGPGLHKQVFHSLARCVAALSAACPQEAAGTASRLVCDARSPHSSTGVKVLAFLSLAEVGQVAGPGPQRELKTVLLEALGSPSEDVRAAAAYALGRVGAGNLPDFLPFLLAQIEAQPRRQYLLLHALREALGAAQPDNLKPYVEDVWALLFQRCESPEEGTRCVVAECIGKLVFVNPPFLLPRFRKQLAAGQPYTRSTVITAVKFLISDQPHSIDPLLKSFIAEFMESLQDPDLNVRRATLTFFNSAVHNKPSLVRDLLDDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMYSLLESCLGQLDICEFLNHVEDGLKDHYDIRMLTFIMLARLAALCPAPVLQRVDRLIEPLRATCTAKVKAGSVKQELEKQDELKRSAMRAVAALMTNPEVRKSPSVADFSTQIRSNPELATLFESIQKDTASGPSMDSMELS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSTGAFYIS ------CCCHHHHHH	47.02	-
3	Phosphorylation	-----MSTGAFYISS -----CCCHHHHHHH	44.37	26022182
9	Phosphorylation	STGAFYISSLLEKMT CCHHHHHHHHHHHHC	11.98	26022182
10	Phosphorylation	TGAFYISSLLEKMTS CHHHHHHHHHHHHCC	27.67	26022182
16	Phosphorylation	SSLLEKMTSSDKDFS HHHHHHHCCCCCCCC	35.83	26022182
17	Phosphorylation	SLLEKMTSSDKDFSP HHHHHHCCCCCCCCC	32.80	26022182
54	Phosphorylation	DWISGDRTQDLALPR HHHCCCCCCCCCCCH	31.04	27097102
65	Phosphorylation	ALPRFMATSDLMSEL CCCHHHHHHHHHHHH	15.81	27097102
66	Phosphorylation	LPRFMATSDLMSELQ CCHHHHHHHHHHHHH	21.14	27097102
70	Phosphorylation	MATSDLMSELQKDSI HHHHHHHHHHHHCCC	42.31	27097102
1234	Phosphorylation	TNPEVRKSPSVADFS HCHHHHCCCCHHHHH	16.31	28432305
1236	Phosphorylation	PEVRKSPSVADFSTQ HHHHCCCCHHHHHHH	36.71	28432305
1246	Phosphorylation	DFSTQIRSNPELATL HHHHHHHCCHHHHHH	59.36	22108457
1261	Phosphorylation	FESIQKDTASGPSMD HHHHHHCCCCCCCCC	29.74	22673903
1263	Phosphorylation	SIQKDTASGPSMDSM HHHHCCCCCCCCCCC	54.02	28432305
1266	Phosphorylation	KDTASGPSMDSMELS HCCCCCCCCCCCCCC	38.45	28432305
1269	Phosphorylation	ASGPSMDSMELS--- CCCCCCCCCCCC---	12.91	28432305
1273	Phosphorylation	SMDSMELS------- CCCCCCCC-------	25.52	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAND2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAND2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAND2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CAND2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.