NFYA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NFYA_MOUSE
• UniProt AC: P23708
• Protein Name: Nuclear transcription factor Y subunit alpha
• Gene Name: Nfya
• Organism: Mus musculus (Mouse).
• Sequence Length: 346
• Subcellular Localization: Nucleus.
• Protein Description: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1..
• Protein Sequence: MEQYTTNSNSSTEQIVVQAGQIQQQQGGVTAVQLQTEAQVASASGQQVQTLQVVQGQPLMVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQQIQLVPPGQIQIQGGQAVQVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVAQTAEGQTIVYQPVNADGTILQQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQGTVTVTLPVAGNVVNSGGMVMMVPGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRILKRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQADEEAMTQIIRVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
265	Phosphorylation	MLEEEPLYVNAKQYH HHCCCCCCCCHHHHH	11.45	28725479
283	Acetylation	KRRQARAKLEAEGKI HHHHHHHHHHHCCCC	41.11	18815279
283	Ubiquitination	KRRQARAKLEAEGKI HHHHHHHHHHHCCCC	41.11	-
289	Acetylation	AKLEAEGKIPKERRK HHHHHCCCCCHHHHH	47.54	18815279
289	Ubiquitination	AKLEAEGKIPKERRK HHHHHCCCCCHHHHH	47.54	-
292	Ubiquitination	EAEGKIPKERRKYLH HHCCCCCHHHHHHHH	68.29	-
296	Ubiquitination	KIPKERRKYLHESRH CCCHHHHHHHHHHHH	59.39	-
319	Phosphorylation	GEGGRFFSPKEKDSP CCCCCCCCCCCCCCC	32.14	29514104
325	Phosphorylation	FSPKEKDSPHMQDPN CCCCCCCCCCCCCCC	27.98	25521595
340	Phosphorylation	QADEEAMTQIIRVS- HHCHHHHHHHHCCC-	24.54	23984901
346	Phosphorylation	MTQIIRVS------- HHHHHCCC-------	25.34	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NFYA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NFYA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NFYA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CREB1_MOUSE	Creb1	physical	17226765
STF1_MOUSE	Nr5a1	physical	20211142
RPB1_MOUSE	Polr2a	physical	15601870
TBP_MOUSE	Tbp	physical	21705419
STF1_MOUSE	Nr5a1	physical	12730328
NFYB_HUMAN	NFYB	physical	26496610
NFYC_HUMAN	NFYC	physical	26496610
SFSWA_HUMAN	SFSWAP	physical	26496610
ZNF3_HUMAN	ZNF3	physical	26496610
MOT4_HUMAN	SLC16A3	physical	26496610
NS1BP_HUMAN	IVNS1ABP	physical	26496610
RM03_HUMAN	MRPL3	physical	26496610
LRCH1_HUMAN	LRCH1	physical	26496610
S18L2_HUMAN	SS18L2	physical	26496610
DGCR8_HUMAN	DGCR8	physical	26496610
HMCES_HUMAN	HMCES	physical	26496610
SFXN3_HUMAN	SFXN3	physical	26496610
OSBL1_HUMAN	OSBPL1A	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.