| UniProt ID | STF1_MOUSE | |
|---|---|---|
| UniProt AC | P33242 | |
| Protein Name | Steroidogenic factor 1 | |
| Gene Name | Nr5a1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 462 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.. | |
| Protein Sequence | MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRSDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 34 | Acetylation | LLTCESCKGFFKRTV EEEHHHCCCHHHHHH | 68.95 | - | |
| 38 | Acetylation | ESCKGFFKRTVQNNK HHCCCHHHHHHCCCC | 44.92 | - | |
| 72 | Acetylation | CPFCRFQKCLTVGMR CCCHHHHHHHHHHHH | 28.62 | - | |
| 119 | Sumoylation | QIRANGFKLETGPPM HHHHCCEECCCCCCC | 46.97 | - | |
| 154 | Phosphorylation | PEPKALVSGPPSGPL CCCCCCCCCCCCCCC | 46.57 | 26643407 | |
| 158 | Phosphorylation | ALVSGPPSGPLGDFG CCCCCCCCCCCCCCC | 57.06 | 26643407 | |
| 168 | Phosphorylation | LGDFGAPSLPMAVPG CCCCCCCCCCCCCCC | 44.57 | 26643407 | |
| 194 | Sumoylation | AFSNRTIKSEYPEPY HCCCCCCCCCCCCCC | 36.30 | - | |
| 203 | Phosphorylation | EYPEPYASPPQQPGP CCCCCCCCCCCCCCC | 31.13 | 12920232 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 203 | S | Phosphorylation | Kinase | CDK7 | P50613 | PSP |
| 203 | S | Phosphorylation | Kinase | CDK7 | Q03147 | Uniprot |
| 203 | S | Phosphorylation | Kinase | MAPK1 | P28482 | GPS |
| 203 | S | Phosphorylation | Kinase | MK01 | P63085 | PhosphoELM |
| 203 | S | Phosphorylation | Kinase | ERK1 | P27361 | PSP |
| 203 | S | Phosphorylation | Kinase | MAPK3 | Q63844 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 203 | S | Phosphorylation |
| - |
| 203 | S | Phosphorylation |
| - |
| 203 | S | Sumoylation |
| - |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of STF1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TBX19_MOUSE | Tbx19 | physical | 20211142 | |
| PRGC1_MOUSE | Ppargc1a | physical | 21108604 | |
| NFYA_MOUSE | Nfya | physical | 12730328 | |
| PITX1_MOUSE | Pitx1 | physical | 12730328 | |
| TF7L2_MOUSE | Tcf7l2 | genetic | 12861022 | |
| CTNB1_HUMAN | CTNNB1 | genetic | 12861022 | |
| CTNB1_MOUSE | Ctnnb1 | physical | 12861022 | |
| SOX2_MOUSE | Sox2 | physical | 12732652 | |
| SOX8_MOUSE | Sox8 | physical | 12732652 | |
| SOX9_MOUSE | Sox9 | physical | 12732652 | |
| ESR1_HUMAN | ESR1 | physical | 11574675 | |
| PNRC2_HUMAN | PNRC2 | physical | 11574675 | |
| MEN1_MOUSE | Men1 | physical | 25591470 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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