SOX9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOX9_MOUSE
• UniProt AC: Q04887
• Protein Name: Transcription factor SOX-9
• Gene Name: Sox9
• Organism: Mus musculus (Mouse).
• Sequence Length: 507
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator. [PubMed: 20940257 Plays a role in chondrocyte differentiation, as part of a complex with ZNF219]
• Protein Sequence: MNLLDPFMKMTDEQEKGLSGAPSPTMSEDSAGSPCPSGSGSDTENTRPQENTFPKGEPDLKKESEEDKFPVCIREAVSQVLKGYDWTLVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTTPKTDVQAGKVDLKREGRPLAEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPNGHPGVPATHGQVTYTGSYGISSTAPTPATAGHVWMSKQQAPPPPPQQPPQAPQAPQAPPQQQAPPQQPQAPQQQQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQISYSPFNLPHYSPSYPPITRSQYDYADHQNSGSYYSHAAGQGSGLYSTFTYMNPAQRPMYTPIADTSGVPSIPQTHSPQHWEQPVYTQLTRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	KGLSGAPSPTMSEDS HCCCCCCCCCCCCCC	32.25	25338131
25	Phosphorylation	LSGAPSPTMSEDSAG CCCCCCCCCCCCCCC	37.35	25338131
30	Phosphorylation	SPTMSEDSAGSPCPS CCCCCCCCCCCCCCC	30.40	25338131
33	Phosphorylation	MSEDSAGSPCPSGSG CCCCCCCCCCCCCCC	24.05	29514104
64	Phosphorylation	EPDLKKESEEDKFPV CCCCCCCCCCCCCCH	55.98	10805756
74	Methylation	DKFPVCIREAVSQVL CCCCHHHHHHHHHHH	22.24	20676277
152	Methylation	LLNESEKRPFVEEAE HHCCCCCCCCHHHHH	26.32	20676285
177	Methylation	PDYKYQPRRRKSVKN CCCCCCCCCCHHCCC	35.19	20676281
178	Methylation	DYKYQPRRRKSVKNG CCCCCCCCCHHCCCC	58.00	20676289
179	Methylation	YKYQPRRRKSVKNGQ CCCCCCCCHHCCCCC	36.56	20676273
181	Phosphorylation	YQPRRRKSVKNGQAE CCCCCCHHCCCCCHH	36.19	10805756
193	Phosphorylation	QAEAEEATEQTHISP CHHHHHHHHHCCCCH	31.72	25619855
196	Phosphorylation	AEEATEQTHISPNAI HHHHHHHCCCCHHHH	18.23	25619855
199	Phosphorylation	ATEQTHISPNAIFKA HHHHCCCCHHHHHHH	12.42	25619855
211	Phosphorylation	FKALQADSPHSSSGM HHHHHCCCCCCCCCC	27.77	10805756
214	Phosphorylation	LQADSPHSSSGMSEV HHCCCCCCCCCCCCC	29.59	25777480
215	Phosphorylation	QADSPHSSSGMSEVH HCCCCCCCCCCCCCC	28.07	25777480
216	Phosphorylation	ADSPHSSSGMSEVHS CCCCCCCCCCCCCCC	41.34	25777480
219	Phosphorylation	PHSSSGMSEVHSPGE CCCCCCCCCCCCCCC	39.74	25777480
223	Phosphorylation	SGMSEVHSPGEHSGQ CCCCCCCCCCCCCCC	39.51	29514104
228	Phosphorylation	VHSPGEHSGQSQGPP CCCCCCCCCCCCCCC	33.94	25777480
231	Phosphorylation	PGEHSGQSQGPPTPP CCCCCCCCCCCCCCC	40.40	25777480
236	Phosphorylation	GQSQGPPTPPTTPKT CCCCCCCCCCCCCCC	45.06	27717184
239	Phosphorylation	QGPPTPPTTPKTDVQ CCCCCCCCCCCCCCC	57.86	25777480
240	Phosphorylation	GPPTPPTTPKTDVQA CCCCCCCCCCCCCCC	28.67	27717184
475	Phosphorylation	NPAQRPMYTPIADTS CCCCCCCCCCCCCCC	16.43	25777480
476	Phosphorylation	PAQRPMYTPIADTSG CCCCCCCCCCCCCCC	11.28	25777480
481	Phosphorylation	MYTPIADTSGVPSIP CCCCCCCCCCCCCCC	20.54	25777480
482	Phosphorylation	YTPIADTSGVPSIPQ CCCCCCCCCCCCCCC	38.04	25777480
486	Phosphorylation	ADTSGVPSIPQTHSP CCCCCCCCCCCCCCC	44.48	25777480
490	Phosphorylation	GVPSIPQTHSPQHWE CCCCCCCCCCCCCCC	20.97	25777480
492	Phosphorylation	PSIPQTHSPQHWEQP CCCCCCCCCCCCCCC	29.64	25777480
501	Phosphorylation	QHWEQPVYTQLTRP- CCCCCCCEEECCCC-	8.75	25777480
502	Phosphorylation	HWEQPVYTQLTRP-- CCCCCCEEECCCC--	19.82	25777480
505	Phosphorylation	QPVYTQLTRP----- CCCEEECCCC-----	30.95	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
64	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
64	S	Phosphorylation	Kinase	PKA	-	Uniprot
211	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
211	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
64	S	Phosphorylation	Phosphorylation at Ser-64 and Ser-211 by PKA increases transcriptional activity and may help delay chondrocyte maturation downstream of PTHLH/PTHrP signaling.	10805756
64	S	Phosphorylation	Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation.	10805756
64	S	Phosphorylation	Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation.	10805756
64	S	Sumoylation	Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation.	10805756
64	S	Sumoylation	Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation.	10805756
211	S	Phosphorylation	Phosphorylation at Ser-64 and Ser-211 by PKA increases transcriptional activity and may help delay chondrocyte maturation downstream of PTHLH/PTHrP signaling.	10805756
211	S	Phosphorylation	Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation.	10805756
211	S	Phosphorylation	Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation.	10805756
211	S	Sumoylation	Phosphorylation at either Ser-64 or Ser-211 is required for sumoylation, but phosphorylation is not dependent on sumoylation.	10805756
211	S	Sumoylation	Sumoylated; phosphorylation at either Ser-64 or Ser-211 is required for sumoylation.	10805756

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOX9_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STF1_MOUSE	Nr5a1	physical	20211142
CREB1_MOUSE	Creb1	physical	19113914
ZBT7A_MOUSE	Zbtb7a	physical	23727861

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.