SOX8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOX8_MOUSE
• UniProt AC: Q04886
• Protein Name: Transcription factor SOX-8
• Gene Name: Sox8
• Organism: Mus musculus (Mouse).
• Sequence Length: 464
• Subcellular Localization: Nucleus .
• Protein Description: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'..
• Protein Sequence: MLDMSEARAQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGGGGRGDTAEAADERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGTLKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSVKTGRSDSDSGTELGHHPGGPMYKADAVLGEAHHHSDHHTGQTHGPPTPPTTPKTDLHQASNGSKQELRLEGRRLVDSGRQNIDFSNVDISELSSEVISNMDTFDVHEFDQYLPLNGHSALPTEPSQATASGSYGGASYSHSGATGIGASPVWAHKGAPSASASPTEAGPLRPQIKTEQLSPSHYNDQSHGSPGRADYGSYSAQASVTTAASATAASSFASAQCDYTDLQASNYYSPYPGYPPSLYQYPYFHSSRRPYASPLLNGLSMPPAHSPSSNWDQPVYTTLTRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	ARAQPPCSPSGTASS HHCCCCCCCCCCCCC	28.07	25293948
16	Phosphorylation	AQPPCSPSGTASSMS CCCCCCCCCCCCCCC	32.27	25293948
18	Phosphorylation	PPCSPSGTASSMSHV CCCCCCCCCCCCCCC	27.92	25293948
20	Phosphorylation	CSPSGTASSMSHVED CCCCCCCCCCCCCCC	26.81	25293948
21	Phosphorylation	SPSGTASSMSHVEDS CCCCCCCCCCCCCCC	23.11	25293948
23	Phosphorylation	SGTASSMSHVEDSDS CCCCCCCCCCCCCCC	26.74	25293948
28	Phosphorylation	SMSHVEDSDSDAPPS CCCCCCCCCCCCCCC	26.05	25293948
30	Phosphorylation	SHVEDSDSDAPPSPA CCCCCCCCCCCCCCC	39.36	25293948
35	Phosphorylation	SDSDAPPSPAGSEGL CCCCCCCCCCCCCCC	26.73	25293948
39	Phosphorylation	APPSPAGSEGLGRAG CCCCCCCCCCCCCCC	30.51	25293948
198	Phosphorylation	HHPGGPMYKADAVLG CCCCCCCHHHCEECC	13.22	29895711
335	Phosphorylation	WAHKGAPSASASPTE EECCCCCCCCCCCCC	34.03	22817900
337	Phosphorylation	HKGAPSASASPTEAG CCCCCCCCCCCCCCC	33.35	28066266
339	Phosphorylation	GAPSASASPTEAGPL CCCCCCCCCCCCCCC	29.84	22817900
341	Phosphorylation	PSASASPTEAGPLRP CCCCCCCCCCCCCCC	35.65	28066266
352	Phosphorylation	PLRPQIKTEQLSPSH CCCCCCCCEECCHHH	30.50	21183079
356	Phosphorylation	QIKTEQLSPSHYNDQ CCCCEECCHHHCCCC	24.85	24899341
358	Phosphorylation	KTEQLSPSHYNDQSH CCEECCHHHCCCCCC	34.92	28066266
360	Phosphorylation	EQLSPSHYNDQSHGS EECCHHHCCCCCCCC	25.44	21183079
364	Phosphorylation	PSHYNDQSHGSPGRA HHHCCCCCCCCCCCC	32.45	28066266
367	Phosphorylation	YNDQSHGSPGRADYG CCCCCCCCCCCCCCC	20.82	24899341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOX8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOX8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOX8_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRRX1_MOUSE	Prrx1	physical	16582099
HXC4_MOUSE	Hoxc4	physical	16582099
PRRX2_MOUSE	Prrx2	physical	16582099
DLX5_MOUSE	Dlx5	physical	16582099
HHEX_MOUSE	Hhex	physical	16582099
UTF1_MOUSE	Utf1	physical	16582099
PO3F3_MOUSE	Pou3f3	physical	16582099
HTF4_MOUSE	Tcf12	physical	16582099
OLIG2_MOUSE	Olig2	physical	16582099
JUN_MOUSE	Jun	physical	16582099
CEBPA_MOUSE	Cebpa	physical	16582099
EGR2_MOUSE	Egr2	physical	16582099
SP1_MOUSE	Sp1	physical	16582099
PAX3_MOUSE	Pax3	physical	16582099

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.