dbPTM

PO3F3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PO3F3_MOUSE
UniProt AC	P31361
Protein Name	POU domain, class 3, transcription factor 3
Gene Name	Pou3f3
Organism	Mus musculus (Mouse).
Sequence Length	497
Subcellular Localization	Nucleus .
Protein Description	Transcription factor that acts synergistically with SOX11 and SOX4 (By similarity). Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3')..
Protein Sequence	MATAASNPYLPGNSLLTAGSIVHSDAAGAGGGGGGGGGGGGGAGGGGGGMQPGSAAVTSGAYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGREDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAHPHPPHPHHAQGPPHHGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHHGLQTSVQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
366	Phosphorylation	RFEALQLSFKNMCKL HHHHHHHHHHHHHHH	22.63	23140645
386	Phosphorylation	KWLEEADSSTGSPTS HHHHHHHCCCCCCCH	36.53	29899451
388	Phosphorylation	LEEADSSTGSPTSID HHHHHCCCCCCCHHH	45.70	29899451
390	Phosphorylation	EADSSTGSPTSIDKI HHHCCCCCCCHHHHH	25.70	30372032
392	Phosphorylation	DSSTGSPTSIDKIAA HCCCCCCCHHHHHHH	39.76	30372032
393	Phosphorylation	SSTGSPTSIDKIAAQ CCCCCCCHHHHHHHC	31.97	29899451
408	Phosphorylation	GRKRKKRTSIEVSVK CCCCCCCCCEEEEHH	42.83	22290434
409	Phosphorylation	RKRKKRTSIEVSVKG CCCCCCCCEEEEHHH	22.30	22290434

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PO3F3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PO3F3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PO3F3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PO3F4_RAT	Pou3f4	physical	9105675

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PO3F3_MOUSE

Related Literatures of Post-Translational Modification