PO3F4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PO3F4_RAT
• UniProt AC: P62516
• Protein Name: POU domain, class 3, transcription factor 4
• Gene Name: Pou3f4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 361
• Subcellular Localization: Nucleus.
• Protein Description: Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain..
• Protein Sequence: MATAASNPYSILSSSSLVHADSAGMQQGSPFRNPQKLLQSDYLQGVPSNGHPLGHHWVTSLSDGGPWSSTLATSPLDQQDVKPGREDLQLGAIIHHRSPHVAHHSPHTNHPNAWGASPAPNSSITSSGQPLNVYSQPGFTVSGMLEHGGLTPPPAAASTQSLHPVLREPPDHGELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPHEVYSHTVKTDASCHDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	TAASNPYSILSSSSL CCCCCCCCCCCCCCC	20.50	27097102
13	Phosphorylation	SNPYSILSSSSLVHA CCCCCCCCCCCCCEE	26.89	27097102
14	Phosphorylation	NPYSILSSSSLVHAD CCCCCCCCCCCCEEC	22.09	27097102
15	Phosphorylation	PYSILSSSSLVHADS CCCCCCCCCCCEECC	25.06	27097102
16	Phosphorylation	YSILSSSSLVHADSA CCCCCCCCCCEECCC	36.04	27097102
22	Phosphorylation	SSLVHADSAGMQQGS CCCCEECCCCCCCCC	27.75	27097102
29	Phosphorylation	SAGMQQGSPFRNPQK CCCCCCCCCCCCHHH	19.27	27097102
261	Phosphorylation	KWLEEADSSTGSPTS HHHHHHHCCCCCCCH	36.53	27097102
262	Phosphorylation	WLEEADSSTGSPTSI HHHHHHCCCCCCCHH	37.02	27097102
263	Phosphorylation	LEEADSSTGSPTSID HHHHHCCCCCCCHHH	45.70	27097102
265	Phosphorylation	EADSSTGSPTSIDKI HHHCCCCCCCHHHHH	25.70	27097102
267	Phosphorylation	DSSTGSPTSIDKIAA HCCCCCCCHHHHHHH	39.76	27097102
268	Phosphorylation	SSTGSPTSIDKIAAQ CCCCCCCHHHHHHHC	31.97	27097102
283	Phosphorylation	GRKRKKRTSIEVSVK CCCCCCCCCCEEEHH	42.83	27097102
284	Phosphorylation	RKRKKRTSIEVSVKG CCCCCCCCCEEEHHH	22.30	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PO3F4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PO3F4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PO3F4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNRPU_HUMAN	HNRNPU	physical	9105675
PO3F3_MOUSE	Pou3f3	physical	9105675
PO3F4_RAT	Pou3f4	physical	9105675
PO3F2_MOUSE	Pou3f2	physical	9105675
PO3F1_MOUSE	Pou3f1	physical	9105675

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.