PO3F2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PO3F2_MOUSE
• UniProt AC: P31360
• Protein Name: POU domain, class 3, transcription factor 2
• Gene Name: Pou3f2
• Organism: Mus musculus (Mouse).
• Sequence Length: 445
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor that plays a key role in neuronal differentiation. [PubMed: 24243019 Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro]
• Protein Sequence: MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
319	Phosphorylation	RFEALQLSFKNMCKL HHHHHHHHHHHHHHH	22.63	23140645
343	Phosphorylation	EADSSSGSPTSIDKI HHHCCCCCCCHHHHH	27.27	24719451
346	Phosphorylation	SSSGSPTSIDKIAAQ CCCCCCCHHHHHHHC	31.97	29899451
361	Phosphorylation	GRKRKKRTSIEVSVK CCCCCCCCCEEEEHH	42.83	22290434
362	Phosphorylation	RKRKKRTSIEVSVKG CCCCCCCCEEEEHHH	22.30	22290434
431	Phosphorylation	AEDVYGGSRDTPPHH CHHCCCCCCCCCCCC	23.71	24719451
434	Phosphorylation	VYGGSRDTPPHHGVQ CCCCCCCCCCCCCCC	37.29	-
442	Phosphorylation	PPHHGVQTPVQ---- CCCCCCCCCCC----	24.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
361	T	Phosphorylation	Kinase	PRKACA	P00517	GPS
362	S	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PO3F2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PO3F2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PO3F4_RAT	Pou3f4	physical	9105675

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.