dbPTM

CEBPA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CEBPA_MOUSE
UniProt AC	P53566
Protein Name	CCAAT/enhancer-binding protein alpha {ECO:0000312\|MGI:MGI:99480}
Gene Name	Cebpa {ECO:0000312\|MGI:MGI:99480}
Organism	Mus musculus (Mouse).
Sequence Length	359
Subcellular Localization	Nucleus . Isoform 4: Nucleus, nucleolus .
Protein Description	Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. [PubMed: 8415748]
Protein Sequence	MESADFYEVEPRPPMSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEHETSIDISAYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAVMSAGAHGPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQPPPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHAAPALGAAGLPGPGSALKGLAGAHPDLRTGGGGGGSGAGAGKAKKSVDKNSNEYRVRRERNNIAVRKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAMGNCA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESADFYEVE -----CCCCCCEECC	31.66	23984901
7	Phosphorylation	-MESADFYEVEPRPP -CCCCCCEECCCCCC	21.44	23984901
7 (in isoform 3)	Phosphorylation	-	21.44	30352176
16	Phosphorylation	VEPRPPMSSHLQSPP CCCCCCCCHHCCCCC	22.00	23984901
17	Phosphorylation	EPRPPMSSHLQSPPH CCCCCCCHHCCCCCC	23.20	23984901
21	Phosphorylation	PMSSHLQSPPHAPSN CCCHHCCCCCCCCCC	46.92	20516642
27	Phosphorylation	QSPPHAPSNAAFGFP CCCCCCCCCCCCCCC	39.63	23984901
159	Sumoylation	ALRPLVIKQEPREED CHHEEEECCCCCCHH	40.92	-
159	Acetylation	ALRPLVIKQEPREED CHHEEEECCCCCCHH	40.92	-
159	Sumoylation	ALRPLVIKQEPREED CHHEEEECCCCCCHH	40.92	-
193	Phosphorylation	PPPHPHASPAHLAAP CCCCCCCCHHHHHCC	21.42	20516642
222	Phosphorylation	HLQPGHPTPPPTPVP ECCCCCCCCCCCCCC	42.63	19303846
226	Phosphorylation	GHPTPPPTPVPSPHA CCCCCCCCCCCCCCC	42.57	19303846
230	Phosphorylation	PPPTPVPSPHAAPAL CCCCCCCCCCCCCCC	29.56	15107404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
21	S	Phosphorylation	Kinase	CDK1	P11440	PSP
193	S	Phosphorylation	Kinase	CDK1	P11440	PSP
193	S	Phosphorylation	Kinase	CDK4	P11802	PSP
193	S	Phosphorylation	Kinase	CDK4	P30285	PSP
193	S	Phosphorylation	Kinase	CDK6	Q64261	PSP
222	T	Phosphorylation	Kinase	GSK3A	P49840	PSP
222	T	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
222	T	Phosphorylation	Kinase	GSK3	-	Uniprot
222	T	Phosphorylation	Kinase	GSK-3_GROUP	-	PhosphoELM
226	T	Phosphorylation	Kinase	GSK3A	P49840	PSP
226	T	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
226	T	Phosphorylation	Kinase	GSK3	-	Uniprot
226	T	Phosphorylation	Kinase	GSK-3_GROUP	-	PhosphoELM
230	S	Phosphorylation	Kinase	GSK3	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	Cop1	Q9R1A8	PMID:23884858

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
193	S	Phosphorylation	15107404
Dephosphorylated at Ser-193 by protein phosphatase 2A (PP2A) through PI3K/AKT signaling pathway regulation.
193	S	Phosphorylation	15107404
Phosphorylation at Ser-193 is required for interaction with CDK2, CDK4 and SWI/SNF complex leading to cell cycle inhibition.
222	T	Phosphorylation	17290224
In liver, both Thr-222 and Thr-226 are phosphorylated only during feeding but not during fasting.
222	T	Phosphorylation	17290224
Phosphorylation at Thr-222 and Thr-226 by GSK3 is constitutive in adipose tissue and lung.
226	T	Phosphorylation	17290224
In liver, both Thr-222 and Thr-226 are phosphorylated only during feeding but not during fasting.
226	T	Phosphorylation	17290224
Phosphorylation at Thr-222 and Thr-226 by GSK3 is constitutive in adipose tissue and lung.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CEBPA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDIT3_MOUSE	Ddit3	physical	20211142
JDP2_MOUSE	Jdp2	physical	20211142
CDK2_MOUSE	Cdk2	physical	20516642
CDK4_MOUSE	Cdk4	physical	20516642
CDK1_MOUSE	Cdk1	physical	20516642
PSD10_MOUSE	Psmd10	physical	20516642
RB_MOUSE	Rb1	physical	8946919
RBL1_MOUSE	Rbl1	physical	10082561
CDK4_MOUSE	Cdk4	physical	11867521
CEBPB_MOUSE	Cebpb	physical	19126543
EP300_HUMAN	EP300	genetic	12861022
TF7L2_MOUSE	Tcf7l2	genetic	12861022
CTNB1_HUMAN	CTNNB1	genetic	12861022
TOP2A_MOUSE	Top2a	physical	26167872
HNRL2_MOUSE	Hnrnpul2	physical	26167872
NOP56_MOUSE	Nop56	physical	26167872
RRP5_MOUSE	Pdcd11	physical	26167872
MYH9_MOUSE	Myh9	physical	26167872
IF4A3_MOUSE	Eif4a3	physical	26167872
HP1B3_MOUSE	Hp1bp3	physical	26167872
NAT10_MOUSE	Nat10	physical	26167872
RPN2_MOUSE	Rpn2	physical	26167872
NOP58_MOUSE	Nop58	physical	26167872
NOL6_MOUSE	Nol6	physical	26167872
ACINU_MOUSE	Acin1	physical	26167872
DDX18_MOUSE	Ddx18	physical	26167872
MATR3_MOUSE	Matr3	physical	26167872
NUP93_MOUSE	Nup93	physical	26167872
MOGS_MOUSE	Mogs	physical	26167872
ZFR_MOUSE	Zfr	physical	26167872
DDX47_MOUSE	Ddx47	physical	26167872
LMNB1_MOUSE	Lmnb1	physical	26167872
SRSF5_MOUSE	Srsf5	physical	26167872
MTA2_MOUSE	Mta2	physical	26167872
HDAC2_MOUSE	Hdac2	physical	26167872
HDAC1_MOUSE	Hdac1	physical	26167872
RU17_MOUSE	Snrnp70	physical	26167872
RBM39_MOUSE	Rbm39	physical	26167872
LBR_MOUSE	Lbr	physical	26167872
RPN1_MOUSE	Rpn1	physical	26167872
SNUT2_MOUSE	Usp39	physical	26167872
MCM4_MOUSE	Mcm4	physical	26167872
RRP1B_MOUSE	Rrp1b	physical	26167872
NPA1P_MOUSE	Urb1	physical	26167872
PININ_MOUSE	Pnn	physical	26167872
INT7_MOUSE	Ints7	physical	26167872
SAP18_MOUSE	Sap18	physical	26167872
SMRD1_MOUSE	Smarcd1	physical	26167872
CEBPZ_MOUSE	Cebpz	physical	26167872
SRSF3_MOUSE	Srsf3	physical	26167872
NU160_MOUSE	Nup160	physical	26167872
RS25_MOUSE	Rps25	physical	26167872
PUM3_MOUSE	D19Bwg1357e	physical	26167872
SIN3A_MOUSE	Sin3a	physical	26167872
GBB2_MOUSE	Gnb2	physical	26167872
STAG1_MOUSE	Stag1	physical	26167872
RRP12_MOUSE	Rrp12	physical	26167872
EWS_MOUSE	Ewsr1	physical	26167872
RPB1_MOUSE	Polr2a	physical	26167872
IF2A_MOUSE	Eif2s1	physical	26167872
NOL10_MOUSE	Nol10	physical	26167872
RS9_MOUSE	Rps9	physical	26167872
H2AZ_MOUSE	H2afz	physical	26167872
SPB1_MOUSE	Ftsj3	physical	26167872
DDX54_MOUSE	Ddx54	physical	26167872
RS14_MOUSE	Rps14	physical	26167872
DDIT3_MOUSE	Ddit3	physical	26167872
2AAA_MOUSE	Ppp2r1a	physical	26167872
INT13_MOUSE	Asun	physical	26167872
RL27_MOUSE	Rpl27	physical	26167872
MYL6_MOUSE	Myl6	physical	26167872
IMB1_MOUSE	Kpnb1	physical	26167872
HDGR2_MOUSE	Hdgfrp2	physical	26167872
SPTB2_MOUSE	Sptbn1	physical	26167872
TOP1_MOUSE	Top1	physical	26167872
HNRPM_MOUSE	Hnrnpm	physical	26167872
GRP78_MOUSE	Hspa5	physical	26167872
RS3_MOUSE	Rps3	physical	26167872
RS4X_MOUSE	Rps4x	physical	26167872
TERA_MOUSE	Vcp	physical	26167872
THOC5_MOUSE	Thoc5	physical	26167872
SMU1_MOUSE	Smu1	physical	26167872
THOC1_MOUSE	Thoc1	physical	26167872
DDX3L_MOUSE	D1Pas1	physical	26167872
PP1A_MOUSE	Ppp1ca	physical	26167872
OGT1_MOUSE	Ogt	physical	26167872
MCM7_MOUSE	Mcm7	physical	26167872
RFC2_MOUSE	Rfc2	physical	26167872
GRAB_MOUSE	Gzmb	physical	26167872
ODB2_MOUSE	Dbt	physical	26167872
RFC3_MOUSE	Rfc3	physical	26167872
PRP4_MOUSE	Prpf4	physical	26167872
SAFB2_MOUSE	Safb2	physical	26167872
SMRD2_MOUSE	Smarcd2	physical	26167872
NU107_MOUSE	Nup107	physical	26167872
FL2D_MOUSE	Wtap	physical	26167872
MED23_MOUSE	Med23	physical	26167872
PP1B_MOUSE	Ppp1cb	physical	26167872
NCOA5_MOUSE	Ncoa5	physical	26167872
BUB3_MOUSE	Bub3	physical	26167872
TCRG1_MOUSE	Tcerg1	physical	26167872
WDR5_MOUSE	Wdr5	physical	26167872
RAD21_MOUSE	Rad21	physical	26167872
RFC4_MOUSE	Rfc4	physical	26167872
RNPS1_MOUSE	Rnps1	physical	26167872
NXF1_MOUSE	Nxf1	physical	26167872
DDX1_MOUSE	Ddx1	physical	26167872
P5CR2_MOUSE	Pycr2	physical	26167872
CDK2_MOUSE	Cdk2	physical	15107404
CDK4_MOUSE	Cdk4	physical	15107404
SMCA2_MOUSE	Smarca2	physical	15107404
PP2AA_MOUSE	Ppp2ca	physical	15107404

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CEBPA_MOUSE

Related Literatures of Post-Translational Modification

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