PSD10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSD10_MOUSE
• UniProt AC: Q9Z2X2
• Protein Name: 26S proteasome non-ATPase regulatory subunit 10
• Gene Name: Psmd10
• Organism: Mus musculus (Mouse).
• Sequence Length: 231
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module (By similarity). Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.; Acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export (By similarity)..
• Protein Sequence: MEGCVSNIMICNLAYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLVKGAHVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLACDEERVEEAKFLVTQGASIYIENKEEKTPLQVAKGGLGLILKRLAESEEASM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Ubiquitination	KERILADKSLATRTD HHHHHCCCCHHCCCC	41.59	22790023
30	Ubiquitination	KERILADKSLATRTD HHHHHCCCCHHCCCC	41.59	22790023
107	Glutathionylation	NAVNQNGCTPLHYAA CCCCCCCCCHHHHHH	4.67	24333276
112	Phosphorylation	NGCTPLHYAASKNRH CCCCHHHHHHCCCCC	16.14	22817900
138	Phosphorylation	NPDAKDHYDATAMHR CCCHHHHHCHHHHHH	19.87	22817900
230	Phosphorylation	LAESEEASM------ HHHHHHHCC------	28.45	28833060

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSD10_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSD10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSD10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS6B_MOUSE	Psmc4	physical	17292836

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.