PRS6B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRS6B_MOUSE
• UniProt AC: P54775
• Protein Name: 26S proteasome regulatory subunit 6B
• Gene Name: Psmc4
• Organism: Mus musculus (Mouse).
• Sequence Length: 418
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides..
• Protein Sequence: MEEIGILVEKIQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEEIGILV -------CCCCCHHH	10.60	16857966
19	Phosphorylation	QDEIPALSVSRPQTG HHHCCCCCCCCCCCC	21.83	26239621
21	Phosphorylation	EIPALSVSRPQTGLS HCCCCCCCCCCCCCC	34.56	26239621
25	Phosphorylation	LSVSRPQTGLSFLGP CCCCCCCCCCCCCCC	42.65	26239621
28	Phosphorylation	SRPQTGLSFLGPEPE CCCCCCCCCCCCCCC	21.55	26239621
41	Phosphorylation	PEDLEDLYSRYKKLQ CCCHHHHHHHHHHHH	11.92	22817900
70	Ubiquitination	DEQKNLKKEFLHAQE HHHHHHHHHHHHHHH	57.79	22790023
80	Acetylation	LHAQEEVKRIQSIPL HHHHHHHHHHHHHCC	47.25	7744061
159	Acetylation	MMLTSDQKPDVMYAD EEEECCCCCCEEEEE	48.45	22733758
238	Acetylation	VGSEFVQKYLGEGPR HCHHHHHHHHCCCCH	36.82	23236377
238	Ubiquitination	VGSEFVQKYLGEGPR HCHHHHHHHHCCCCH	36.82	22790023
255	Ubiquitination	RDVFRLAKENAPAII HHHHHHHHHCCCEEE	56.97	22790023
272	Phosphorylation	DEIDAIATKRFDAQT ECCCHHHHCCCCCCC	19.35	22871156
273	Ubiquitination	EIDAIATKRFDAQTG CCCHHHHCCCCCCCC	41.88	22790023
346	Phosphorylation	RQKRLIFSTITSKMN HHHHHHHHHHHHCCC	16.35	22006019
347	Phosphorylation	QKRLIFSTITSKMNL HHHHHHHHHHHCCCC	19.95	22817900
397	Acetylation	NRYIVLAKDFEKAYK CEEEEEECCHHHHHH	59.81	22826441
397	Succinylation	NRYIVLAKDFEKAYK CEEEEEECCHHHHHH	59.81	23954790
401	Acetylation	VLAKDFEKAYKTVIK EEECCHHHHHHHHHC	57.94	-
404	Malonylation	KDFEKAYKTVIKKDE CCHHHHHHHHHCHHH	40.97	26320211
418	Acetylation	EQEHEFYK------- HHHCCCCC-------	60.22	68815

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRS6B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRS6B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRS6B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PRS6B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.