SRSF5_MOUSE - dbPTM
SRSF5_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SRSF5_MOUSE
UniProt AC O35326
Protein Name Serine/arginine-rich splicing factor 5
Gene Name Srsf5
Organism Mus musculus (Mouse).
Sequence Length 269
Subcellular Localization Nucleus .
Protein Description May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre-mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity)..
Protein Sequence MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIEGSKRHRSRSRSRSRTRSSSRSRSRSRSRRSKSYSRSRSRSRSRSKSRSGSRSPVPEKSQKRGSSSRSKSPASVDRQRSRSRSRSRSVDSGN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSGCRVFIG
------CCCCEEEEE		46.7529514104
5Methylation---MSGCRVFIGRLN
---CCCCEEEEECCC		29.8816187987
10MethylationGCRVFIGRLNPAARE
CCEEEEECCCHHHHH		26.8616187997
16MethylationGRLNPAAREKDVERF
ECCCHHHHHHHHHHH		54.3116188007
55PhosphorylationRDADDAVYELDGKEL
CCCCCCEEEECCHHH		16.7018563927
80MethylationRARSRGGRGRGRYSD
HHHCCCCCCCCCCCC		34.1616289085
82MethylationRSRGGRGRGRYSDRF
HCCCCCCCCCCCCCC		25.6716289095
85PhosphorylationGGRGRGRYSDRFSSR
CCCCCCCCCCCCCCC		20.1129176673
86PhosphorylationGRGRGRYSDRFSSRR
CCCCCCCCCCCCCCC		18.2026060331
88MethylationGRGRYSDRFSSRRPR
CCCCCCCCCCCCCCC		20.7124381511
90PhosphorylationGRYSDRFSSRRPRND
CCCCCCCCCCCCCCC		8.7125266776
91PhosphorylationRYSDRFSSRRPRNDR
CCCCCCCCCCCCCCC		5.1529176673
116PhosphorylationRLIVENLSSRVSWQD
CEEEECCHHCCCHHH		27.9026824392
117PhosphorylationLIVENLSSRVSWQDL
EEEECCHHCCCHHHH		39.6122942356
120PhosphorylationENLSSRVSWQDLKDF
ECCHHCCCHHHHHHH		20.2225266776
125UbiquitinationRVSWQDLKDFMRQAG
CCCHHHHHHHHHHHC		58.1522790023
153PhosphorylationEGVVEFASYGDLKNA
CCCEEEHHHHHHHHH		34.6626745281
154PhosphorylationGVVEFASYGDLKNAI
CCEEEHHHHHHHHHH		15.9526745281
163UbiquitinationDLKNAIEKLSGKEIN
HHHHHHHHHHCCCCC		41.53-
165PhosphorylationKNAIEKLSGKEINGR
HHHHHHHHCCCCCCE		41.44-
167AcetylationAIEKLSGKEINGRKI
HHHHHHCCCCCCEEE		35.9623806337
180PhosphorylationKIKLIEGSKRHRSRS
EEEEEECCHHHHHHH		31.3228066266
193PhosphorylationRSRSRSRTRSSSRSR
HHHCHHCCHHHHHHH		32.8029895711
195PhosphorylationRSRSRTRSSSRSRSR
HCHHCCHHHHHHHHH		24.1229895711
210PhosphorylationSRSRRSKSYSRSRSR
HHHHHHHHHHHHHHH		52.1520531401
211PhosphorylationRSRRSKSYSRSRSRS
HHHHHHHHHHHHHHH		29.5920531401
212PhosphorylationSRRSKSYSRSRSRSR
HHHHHHHHHHHHHHC		16.3120531401
214PhosphorylationRSKSYSRSRSRSRSR
HHHHHHHHHHHHCCC		28.0520531401
224PhosphorylationRSRSRSKSRSGSRSP
HHCCCCCCCCCCCCC		49.1025159016
226PhosphorylationRSRSKSRSGSRSPVP
CCCCCCCCCCCCCCC		49.0923684622
228PhosphorylationRSKSRSGSRSPVPEK
CCCCCCCCCCCCCHH		26.4323684622
230PhosphorylationKSRSGSRSPVPEKSQ
CCCCCCCCCCCHHHH		48.8023684622
241PhosphorylationEKSQKRGSSSRSKSP
HHHHCCCCCCCCCCC		38.6328066266
242PhosphorylationKSQKRGSSSRSKSPA
HHHCCCCCCCCCCCH		29.2228066266
243PhosphorylationSQKRGSSSRSKSPAS
HHCCCCCCCCCCCHH		32.3728066266
245PhosphorylationKRGSSSRSKSPASVD
CCCCCCCCCCCHHHH		50.4823684622
247PhosphorylationGSSSRSKSPASVDRQ
CCCCCCCCCHHHHHH		60.3926824392
250PhosphorylationSRSKSPASVDRQRSR
CCCCCCHHHHHHHHH		29.3123684622
256PhosphorylationASVDRQRSRSRSRSR
HHHHHHHHHHHHHHC		34.6323684622
260PhosphorylationRQRSRSRSRSRSVDS
HHHHHHHHHHCCCCC		34.67-
262PhosphorylationRSRSRSRSRSVDSGN
HHHHHHHHCCCCCCC		34.67-
264PhosphorylationRSRSRSRSVDSGN--
HHHHHHCCCCCCC--		39.32-
267PhosphorylationSRSRSVDSGN-----
HHHCCCCCCC-----		52.66-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
86SPhosphorylationKinaseAKT2Q60823
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SRSF5_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SRSF5_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SRSF5_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SRSF5_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225; SER-227; SER-229;SER-231; SER-246; SER-248; SER-251; SER-261; SER-263; SER-265 ANDSER-268, AND MASS SPECTROMETRY.

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