CEBPZ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CEBPZ_MOUSE
• UniProt AC: P53569
• Protein Name: CCAAT/enhancer-binding protein zeta
• Gene Name: Cebpz
• Organism: Mus musculus (Mouse).
• Sequence Length: 1052
• Subcellular Localization: Nucleus.
• Protein Description: Stimulates transcription from the HSP70 promoter..
• Protein Sequence: MSADQEPVAFLAKQPWRPKQVTEDPDEEDEEDGDEGKNGFSLEEVLRLGGTKQDYLMLATLDENEEVVDGGKKGTIDDLQQGELESFIQNLNLAKYSKSLIEEDEPEKKENASKKEAKLLKVENKKQKATEGKKTSEKKVKNKTVAEQRPESCPVSKAKKDKQPDVFEFLERQTMLLRPGGKWYDMEYSGEYSLEPQPPDVVSKYKALAQKLYEHEVSLFKSKTNNQKGGSSTWMKAIVSSGTLADRMAAMILLIQDDAVHTLQFVETLMSLVKKKGSKQQCLMALDTFKELLITDLLPDSRKLRVFSQHPFHKLEEMSSGNKDSRDRRLILWYYEHQLKHLVAEFVQVLETLSHDSLVTTKTRALVAAHELLCDKPEEEKALLVQVINKLGDPQNRIATKASHLLEVLLRKHPNMKGVVCGEIERLLFRSNISPKAQYYAICFLNQMVLSHEESELANKLITLYFCFFRTCIKKKDIESKMLSAILTGVNRAYPYSQIGDDKVREQVDTLFKVLHVVNFNTSVQALMLLFQVMNSQQTISDRYYTALYRKMLDPGLTTCSKQAMFLNLIYKSLKADIMLRRVKAFVKRLLQVTCTQMPPFICGALYLVSEILKAKPDLRSQLDDHPESDEENFVDVGDDSDDEKFTDADKGTATDAVKEVESKETEPESSAEAEKPKAASWVHFDNLKGGKQIKTYDPFSRNPLFCGAENTTLWELKKLSEHFHPSVALFAKTILEGNCIQYSGDPLQDFTLMRFLDRFVYRNPKLHKGKENTDSVVMQPKRKHFMKNVRDLAVNSKEFLAKEESQIPVDEVFFYRYYKKVAVVKDKQKRSADEESIEDIDDEEFENMIDTFEDDNCFPPGKDDIDFASNMKKTKGAKADLEDSESSDGELGDLDDDEVSLGSMNDEDFEIDEDGGTFMDVSDDESEDAPEFADANPKANTKKSKRKSEDDFDFAGSFQGQKKKKKSFNDSSLFVSAEEFGHLLDENMGSKFDTIGMNAMANRDNASFKQLKWEAERDDWLHNRDVKSIIKKKKNFRKKMKAPQKPKRQRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSADQEPVA ------CCCCCCCHH	52.43	29514104
118	Acetylation	NASKKEAKLLKVENK CCCHHHHHHHHHHHH	56.28	19864081
121	Acetylation	KKEAKLLKVENKKQK HHHHHHHHHHHHHHH	58.92	30985533
128	Acetylation	KVENKKQKATEGKKT HHHHHHHHCCCCCCC	67.18	19864089
143	Acetylation	SEKKVKNKTVAEQRP CCHHHCCCCHHHHCC	38.36	23806337
240	Phosphorylation	TWMKAIVSSGTLADR HHHHHHHCCCCHHHH	19.55	28066266
241	Phosphorylation	WMKAIVSSGTLADRM HHHHHHCCCCHHHHH	25.54	28066266
243	Phosphorylation	KAIVSSGTLADRMAA HHHHCCCCHHHHHHH	22.26	28066266
374	S-nitrosocysteine	VAAHELLCDKPEEEK HHHHHHHCCCCHHHH	11.19	-
374	S-nitrosylation	VAAHELLCDKPEEEK HHHHHHHCCCCHHHH	11.19	20925432
439 (in isoform 2)	Phosphorylation	-	10.34	28609623
440 (in isoform 2)	Phosphorylation	-	4.20	28609623
480	Phosphorylation	IKKKDIESKMLSAIL HCHHHHHHHHHHHHH	24.57	23737553
621	Phosphorylation	KAKPDLRSQLDDHPE HHCCCHHHHCCCCCC	42.25	27087446
629	Phosphorylation	QLDDHPESDEENFVD HCCCCCCCCHHCCCC	55.56	27087446
641	Phosphorylation	FVDVGDDSDDEKFTD CCCCCCCCCCCCCCC	52.26	27087446
647	Phosphorylation	DSDDEKFTDADKGTA CCCCCCCCCCCCCCC	41.15	25619855
653	Phosphorylation	FTDADKGTATDAVKE CCCCCCCCCCHHHHH	31.93	25619855
655	Phosphorylation	DADKGTATDAVKEVE CCCCCCCCHHHHHHH	25.08	25619855
666	Phosphorylation	KEVESKETEPESSAE HHHHCCCCCCCCCHH	61.65	29514104
670	Phosphorylation	SKETEPESSAEAEKP CCCCCCCCCHHCCCC	45.63	25159016
671	Phosphorylation	KETEPESSAEAEKPK CCCCCCCCHHCCCCC	28.59	25159016
769	Acetylation	YRNPKLHKGKENTDS HHCCCCCCCCCCCCC	80.33	7711753
771	Acetylation	NPKLHKGKENTDSVV CCCCCCCCCCCCCCC	53.23	7711763
784	Acetylation	VVMQPKRKHFMKNVR CCCCCCHHHHHHHHH	47.52	7711773
837	Phosphorylation	KRSADEESIEDIDDE CCCCCHHHCCCCCHH	29.27	-
949	Phosphorylation	TKKSKRKSEDDFDFA CHHHCCCCCCCCCCC	50.74	28833060
958	Phosphorylation	DDFDFAGSFQGQKKK CCCCCCCCCCCCCCC	15.80	-
968	Phosphorylation	GQKKKKKSFNDSSLF CCCCCCCCCCCCCCE	37.86	26643407
972	Phosphorylation	KKKSFNDSSLFVSAE CCCCCCCCCCEEEHH	30.00	26643407
973	Phosphorylation	KKSFNDSSLFVSAEE CCCCCCCCCEEEHHH	28.79	26643407
977	Phosphorylation	NDSSLFVSAEEFGHL CCCCCEEEHHHHHHH	23.72	-
1029	Phosphorylation	LHNRDVKSIIKKKKN CCCCHHHHHHHHHHH	29.42	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CEBPZ_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CEBPZ_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CEBPZ_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CEBPZ_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.