dbPTM

RRP12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RRP12_MOUSE
UniProt AC	Q6P5B0
Protein Name	RRP12-like protein
Gene Name	Rrp12
Organism	Mus musculus (Mouse).
Sequence Length	1295
Subcellular Localization	Nucleus, nucleolus. Nucleus membrane Single-pass membrane protein.
Protein Description
Protein Sequence	MGRSGKLPSGVSAKLKRWKKGHSSDSNPATCRHRQAARSRFFSRPSGKSDLTVDAVKLHNELQSGTLSLGKSQAPETTMDQDPEVAFTEKSSGTFLSGLSDCTNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAALMTTMEAVESPESLAAVAYLLNLVLKRVPSPVLMKKFSDTSKAFMDIMSAQASSGSTSALRWVLSCLAILLRKQDLEAWGYPITLQVYHGLLSFTVHAKPKIRKAAQHGVCSVLKGSDFMFGEKAPAHHPAAVSTAKFCIQEIEKSGGSKEATTTLHMLTLLKDMLPCFPEGLVKSCSETLLRVMTLNHVLVTACAMQAFHNLFHAKPSPSTLSAELNAQIVTALYDYVPSENDLQPLLAWLKVMEKAHINLVRLQRDLGLGHLARFFGTAVTCLLSPHSQVAAAATQTLKEILKECVAPHIADIGSVTSSASGPPQYITKMFRAVEEGLTYKFHAAWSSVLQLLGVFFEACGKQAHPVMKKCLQSLCDLRLSPHFPHTAALDQAVGAAVTSMGPEVVLQAVPLEIDGSEETLDFPRSWLLPVIRDHVRETRLGFFTTYFLPLATTLKRKAMDLAQAGSTVESKIYDTLQWQIWTLLPGFCTRPTDVAASFKGLARTLGTAINERPDLRVTVCQALRTLITKGCEAEADRAEVSRFAKNFLPILFNLYGQPVAAGEAAAPRRAVLETIKTYLTITEAQLVNSFLEKATEKVLDPASSDFTRLSVLDLVVALAPYSDEAAISKLYSTIRPYLESKVHGVQKKAYRVLEEVCASSQGPAARFVQSHLDDLKKTLLDSLRTTSSPAKRPRLKCLIHIVKTLSAEHEEFIAALIPEVILCTKEVSVGARKSAFTLLVEMGHAFLRFGSNQEDALQRYLVLIYPGLLGAVTTVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVKSALGFIKVAVVVMDVVHLAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFIKFTRKFGFELVKGLLPAEYHKVLINIRKAETRAKKHRALSQAAVEEEEEEEEEEEPVQSKGDSIEEILADSEDEDEEEERGRGKEQRKLARQRSRAWLKEGGGDEPLNFLDPKVAHRVLATQPGPGRGKKRDHGFKLSADGRLIIREEEDGNKVEEEDGTKGEDEDMTDAMEDASVRSKKKLKRQREDEEDELEIPPRYQAGGSGIHRPVAKKAAPGAEYKAKKAKGDVKKKGRLDPYAYVPLNRSKLNRRKKVKLQGQFKGLVKATQRGSQAGHKLRRKDRRRP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Acetylation	LPSGVSAKLKRWKKG CCCCHHHHHHHHHCC	47.22	23806337
49	Phosphorylation	FSRPSGKSDLTVDAV CCCCCCCCCCEEEEH	41.18	28066266
52	Phosphorylation	PSGKSDLTVDAVKLH CCCCCCCEEEEHHHH	22.72	28066266
72	Phosphorylation	GTLSLGKSQAPETTM CCCCCCCCCCCCCCC	29.76	27087446
77	Phosphorylation	GKSQAPETTMDQDPE CCCCCCCCCCCCCCC	26.76	-
88	Phosphorylation	QDPEVAFTEKSSGTF CCCCCEEEECCCCCC	32.53	25521595
91	Phosphorylation	EVAFTEKSSGTFLSG CCEEEECCCCCCCCC	27.97	26745281
92	Phosphorylation	VAFTEKSSGTFLSGL CEEEECCCCCCCCCC	53.58	26745281
94	Phosphorylation	FTEKSSGTFLSGLSD EEECCCCCCCCCCCC	24.29	21659605
97	Phosphorylation	KSSGTFLSGLSDCTN CCCCCCCCCCCCCCC	33.23	26643407
100	Phosphorylation	GTFLSGLSDCTNVTF CCCCCCCCCCCCCCH	33.88	26643407
103	Phosphorylation	LSGLSDCTNVTFSKV CCCCCCCCCCCHHHH	37.40	26643407
106	Phosphorylation	LSDCTNVTFSKVQRF CCCCCCCCHHHHHHH	25.02	22871156
116	Phosphorylation	KVQRFWESNSAAHKE HHHHHHHCCHHHHHH	27.04	28066266
118	Phosphorylation	QRFWESNSAAHKEIC HHHHHCCHHHHHHHH	35.79	28066266
199	Phosphorylation	KAFMDIMSAQASSGS HHHHHHHHHHHCCCC	19.98	29895711
457	Phosphorylation	PHIADIGSVTSSASG HHHHCCCCCCCCCCC	23.66	-
640	Phosphorylation	RPTDVAASFKGLART CCHHHHHHHHHHHHH	20.11	23140645
647	Phosphorylation	SFKGLARTLGTAINE HHHHHHHHHHHHHHH	24.75	24759943
894	Phosphorylation	HAFLRFGSNQEDALQ HHHHHCCCCHHHHHH	32.40	28066266
1050	Phosphorylation	AKKHRALSQAAVEEE HHHHHHHHHHHHHHH	19.45	30635358
1073	Phosphorylation	PVQSKGDSIEEILAD CCCCCCCCHHHHHHC	40.34	25619855
1081	Phosphorylation	IEEILADSEDEDEEE HHHHHHCCCCCCHHH	41.14	27087446
1104	Phosphorylation	RKLARQRSRAWLKEG HHHHHHHHHHHHHCC	20.29	-
1214	Phosphorylation	PRYQAGGSGIHRPVA CCCCCCCCCCCCCHH	33.39	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RRP12_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RRP12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RRP12_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RRP12_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RRP12_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1081, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1081, AND MASSSPECTROMETRY.	19367708 [Abstract]