MED23_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED23_MOUSE
• UniProt AC: Q80YQ2
• Protein Name: Mediator of RNA polymerase II transcription subunit 23
• Gene Name: Med23
• Organism: Mus musculus (Mouse).
• Sequence Length: 1367
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Also required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling..
• Protein Sequence: METQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWSGLSQESHEQCVQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDSLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKAILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNGDSTLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSHRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYKVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQSDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVNVISSSSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEALLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAVPPQALNSGSPAPQSNQVPASLPVTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
211	Phosphorylation	LVSDFVDTFRPTARI HHHHHHHHCCCCHHH	19.08	-
253	Ubiquitination	ATLRFPLKGLLPYDK CCCCCCCCCCCCCCC	47.99	-
260	Ubiquitination	KGLLPYDKDLFEPQT CCCCCCCCCCCCHHH	50.95	-
291	Ubiquitination	CNMLGLNKQHKQRCP HHHHCCCHHHHCCCC	59.84	-
465	Ubiquitination	LQQSLRNKSLQMNDY HHHHHHCCCCCCCHH	46.22	-
673	Ubiquitination	TRFLNDPKTVLSAES HHHHCCCCCCCCCCC	54.88	-
718	Phosphorylation	WCKDILQTIMNFTPH CHHHHHHHHHHCCCC	20.81	25777480
723	Phosphorylation	LQTIMNFTPHNWASH HHHHHHCCCCCHHHC	20.73	25777480
729	Phosphorylation	FTPHNWASHTLSCFP CCCCCHHHCHHCCCC	14.49	25777480
731	Phosphorylation	PHNWASHTLSCFPAP CCCHHHCHHCCCCHH	20.19	25777480
733	Phosphorylation	NWASHTLSCFPAPLQ CHHHCHHCCCCHHHH	18.18	25777480
800	Phosphorylation	LWKMLLETDHISQIG HHHHHHCCCCHHHHH	32.61	28059163
804	Phosphorylation	LLETDHISQIGYKVL HHCCCCHHHHHHHHH	16.60	28059163
1082	Ubiquitination	LVDTMAGKSPGPFPN HHHHHCCCCCCCCCC	43.89	-
1349	Phosphorylation	VPPQALNSGSPAPQS CCHHHHCCCCCCCCC	41.31	25293948
1351	Phosphorylation	PQALNSGSPAPQSNQ HHHHCCCCCCCCCCC	20.08	26643407
1356	Phosphorylation	SGSPAPQSNQVPASL CCCCCCCCCCCCCCC	28.33	25293948
1362	Phosphorylation	QSNQVPASLPVTQ-- CCCCCCCCCCCCC--	27.43	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED23_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED23_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED23_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MED23_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.