| UniProt ID | SMU1_MOUSE | |
|---|---|---|
| UniProt AC | Q3UKJ7 | |
| Protein Name | WD40 repeat-containing protein SMU1 | |
| Gene Name | Smu1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 513 | |
| Subcellular Localization | Cytoplasm . Nucleus . Nucleus speckle . Colocalizes with SRSF1 in nuclear speckles. | |
| Protein Description | Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species. Regulates alternative splicing of the HSPG2 pre-mRNA. Required for normal mitotic spindle assembly and normal progress through mitosis.. | |
| Protein Sequence | MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MSIEIESS -------CCCEECHH | 9.10 | - | |
| 2 | Acetylation | ------MSIEIESSD ------CCCEECHHH | 29.00 | - | |
| 2 | Phosphorylation | ------MSIEIESSD ------CCCEECHHH | 29.00 | 26824392 | |
| 22 | Phosphorylation | MQYLKENSLHRALAT HHHHHHCCHHHHHHH | 27.01 | - | |
| 190 | Ubiquitination | TIDLFRGKAAVKDVE EEEEECCCCCCCCHH | 28.99 | - | |
| 194 | Ubiquitination | FRGKAAVKDVEEEKF ECCCCCCCCHHHHCC | 51.86 | - | |
| 295 | Phosphorylation | IKVWKIQSGQCLRRF EEEEEECCCHHHHHH | 34.01 | 26824392 | |
| 312 | S-nitrosocysteine | AHSKGVTCLSFSKDS HHHCCCEEEEECCCH | 2.52 | - | |
| 312 | S-nitrosylation | AHSKGVTCLSFSKDS HHHCCCEEEEECCCH | 2.52 | 20925432 | |
| 349 | Phosphorylation | LKEFRGHSSFVNEAT HHHHCCCCCCCCEEE | 28.44 | 24759943 | |
| 350 | Phosphorylation | KEFRGHSSFVNEATF HHHCCCCCCCCEEEE | 27.78 | 24759943 | |
| 356 | Phosphorylation | SSFVNEATFTQDGHY CCCCCEEEECCCCEE | 22.49 | 24759943 | |
| 358 | Phosphorylation | FVNEATFTQDGHYII CCCEEEECCCCEEEE | 22.77 | 24759943 | |
| 363 | Phosphorylation | TFTQDGHYIISASSD EECCCCEEEEEECCC | 12.89 | 24759943 | |
| 366 | Phosphorylation | QDGHYIISASSDGTV CCCEEEEEECCCCCE | 16.73 | 24759943 | |
| 379 | Acetylation | TVKIWNMKTTECSNT CEEEEECCCCCCCCC | 49.43 | 22826441 | |
| 386 | Phosphorylation | KTTECSNTFKSLGST CCCCCCCCHHHCCCC | 19.02 | - | |
| 436 | Phosphorylation | GQIVRSFSSGKREGG CCEEEECCCCCCCCC | 39.15 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SMU1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SMU1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SMU1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SMU1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
