dbPTM

PUM3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PUM3_MOUSE
UniProt AC	Q8BKS9
Protein Name	Pumilio homolog 3 {ECO:0000305}
Gene Name	Pum3 {ECO:0000312\|MGI:MGI:106253}
Organism	Mus musculus (Mouse).
Sequence Length	647
Subcellular Localization	Nucleus, nucleolus . Nucleus, nucleoplasm . Chromosome . Localizes predominantly in the nucleolus with minor punctate signals in the nucleoplasm.
Protein Description	Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells..
Protein Sequence	MEVKGKKKFTGKSPQTSQGKNKFHKNSESSSSKTFPRKAVKEGGPKVTSKNFEKGATKPGKKGVKQFKNKPQGGKGPKDKFQKANKFSKKRKFQPDGESDESGAKKPKWDDFKKKKKELKQSRQLSDKTNYDIVVRAKHIWESLRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTRVIQCFIQYGNEEQRKQAFQELQGDLVELSKAKYSRNIVKKFLMYGSKPQVAEIIRSFKGHVRKMLRHSEASAIVEYAYNDKAILEQRNMLTEELYGNTFQLYKSADHPTLDKVLELQPAKLELIMDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKPRSELIEAIREAVVYLAHTHDGARVAMHCLWHGTPKDRKVIVKTMKTYVEKVANGQYSHLVLLAAFDCIDDTKLVKQIIISEIISSLPSIVNDKYGRKVLLYLMSPRDPAHTVPELIELLQKGDGNAHSKKDTAIRRRELLESISPALLSYLQGHTQEVVLDKSACVLVSDMLGSATGDVQPAMDAIASLAAAELHPGGKDGELHVAEHPAGHLVLKWLLEQDKKMKESGKEGCFAKTLVERVGMKNLKSWASINRGAIILSSLLQSCDQEVVNKVKGGLKPLIPTLEKNKSSSRGIQTLLEKLTA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
10	Phosphorylation	VKGKKKFTGKSPQTS CCCCCCCCCCCCCCC	25367039
13	Phosphorylation	KKKFTGKSPQTSQGK CCCCCCCCCCCCCCC	25263469
16	Phosphorylation	FTGKSPQTSQGKNKF CCCCCCCCCCCCCCC	25367039
17	Phosphorylation	TGKSPQTSQGKNKFH CCCCCCCCCCCCCCC	25367039
33	Acetylation	NSESSSSKTFPRKAV CCCCCCCCCCCHHHH	23806337
92	Acetylation	NKFSKKRKFQPDGES HHHCCCCCCCCCCCC	23806337
99	Phosphorylation	KFQPDGESDESGAKK CCCCCCCCCCCCCCC	25521595
102	Phosphorylation	PDGESDESGAKKPKW CCCCCCCCCCCCCCH	23375375
143	Phosphorylation	RAKHIWESLRRKDCD HHHHHHHHHHCCCCC	21454597
248	Phosphorylation	VRKMLRHSEASAIVE HHHHHHHCCHHHHHH	26370283
422	Phosphorylation	LVKQIIISEIISSLP HHHHHHHHHHHHCCH	22871156
426	Phosphorylation	IIISEIISSLPSIVN HHHHHHHHCCHHHHC	22871156
436	Phosphorylation	PSIVNDKYGRKVLLY HHHHCCCCCCEEEEE	22871156
439	Acetylation	VNDKYGRKVLLYLMS HCCCCCCEEEEEECC	7720485
565	Acetylation	KWLLEQDKKMKESGK HHHHHHHHHHHHHCC	7611819

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PUM3_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PUM3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PUM3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PUM3_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PUM3_MOUSE

Related Literatures of Post-Translational Modification