RRP5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRP5_MOUSE
• UniProt AC: Q6NS46
• Protein Name: Protein RRP5 homolog
• Gene Name: Pdcd11
• Organism: Mus musculus (Mouse).
• Sequence Length: 1862
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity)..
• Protein Sequence: MANLEESFPRGGTRKLHKSEKSSQQVVEQDNLFDVSTEEGPIKRKKSQKGPAKTKKLKIEKRKSIKSIKEKFEILSLESLCEGMRILGCVKEVSELELVVSLPNGLQGFVQVTEVCDAYTQKLNEQVAQEEPLEDLLRLPELFSPGMLVRCVVSSLDVTESGKKSVKLSVNPKRVNKVLSADALRPGMLLTGTVSSLEDHGYLVDIGVGGTRAFLSLKKAQEYIRQKNKGAKFKVGQYLTCVVEEVKSNGGVVSLSVEHSEVSSAFATEEQSWNLNNLLPGLLVKAQVQKVTQFGLQLNFLTFFKGLVDFMHLEPKKMGSYSSNQTVKACILCVHPRTRVVRLSLRPIFLHPGRPLTRISYQQLGAVLDDVPVQGFFKNAGAIFRLKDGVLAYARVSHLSDSKKAFNAEAFKPGSTHKCRIIDYSQMDELALLSLRKSIIAAPFLRYHDIKIGTVVKGTVLAIKPFGILVKVGEQIKGLVPSMHLADIMMKNPEKKYSPGDEVKCRVLLCDPEAKKLIMTLKKTLVTSKLSLITCYEGAKPGLQTHGVIIRVKDYGCIVKFYNDVQGLVPKHELSTQHIPDPETVFYTGQVVKVAVLSCEPSKERMLLSFRLLSDSRPKDPGVESSQKKTGAVRIGQLVDVKVLEKTKTGLEVAILPHNTPAFLPTPHLSDHAANGPLLHHWLQTGDTLHRVLCLSQSERHILLCRKPALVSTVEGGQDPKSLSEIQPGMLLIGFVKCIKEYGVFVQFPSGLSGLSPKTIMSDKFVTTPSEHFVEGQTVVAKVTNVDESKQRMLLSLRLSDCSLGDSASTSFLLLCQCLEELQGIRSLMSNQDSVLIQTLADMTPGMVLDAVVHEVLEDGSVVFSSDPVPDLVLRASRYHRAGQEVEPGQKKKVVVLHVDMLKLEVHVSLHQDLVNRKTRKLRKSSRHQGIVQHLEESFAVASLVETGHLVAFSLISHLNDTFHFDSEKLRVGQGVCLTLKTTEPGVTGLILAVEGPASKRTRMPVQRDSETVDDKGEEKEEEEEEEEKEEENLTVKSKKRHSLAIGDKVTGTIKAVKATHVVVTLADGFVGCIHASRILDDVPVGTSPTTTLKAGKKVTARVIGGRDVKTSKFLPISHPRFVLTILELSVRPSELKGSYSALNTHSESPVEKIRQYQAGQTVTCFFKKYNVMKKWLEVDIGPDIRGRIPLLLTSLSFKVLKHPDKKFQVGQAIEATVVDPDVPRAFLCLSLIGPYRLEEGEVAMGRVMKVVPNRGLTVSFPFGKIGKVSMFHLSDSYSEAPLEDFCPQKIVRCYILSTAHRVLALSLRSSRTNRETKNRIEDPEINSIEDVKEGQLLRGYVKCVLPSSVIIGLGPSVLGLAKYSHVSECVPPEKELYNGCLPEGKLVTAKVLRVNPMKNLIELSLLPSDTGRPDVFSPAPEPKQEERSGGAEEGQKRKEKNQKRREEKEEPQKSQRGGRGKRERQESESEQELVNKRPKKSGAAEEDDSGVEVYYREGEDEVGEPKLPPRGKQTKSTEVPRLHLSSGFLWDVGLDSLTPALPLREESSDSEDEQPHQAKKKKGKKERELEKQKAEKELSRIEEALMDPGRQPESADDFDRLVLSSPNSSILWLQYMAFHLQATEIEKARAVAERALKTISFREEQEKLNVWVALLNLENMYGSQESLTKVFERAVQYNEPLKVFLHLADIYTKSEKYKEAGELYNRMLKRFRQEKAVWIKYGAFVLGRSQAGASHRVLQRALECLPAKEHVDVIVKFAQLEFQLGDVERAKAIFENTLSTYPKRTDVWSVYIDMTIKHGSQTAVRDIFERVIHLSLAPKRMKFFFKRYLDYEKQHGTEKDVQAVKAKALEYVEAKSSALED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MANLEESFP ------CCCHHHHCC	40.39	-
7	Phosphorylation	-MANLEESFPRGGTR -CCCHHHHCCCCCCC	31.04	22006019
23	Phosphorylation	LHKSEKSSQQVVEQD CCCCCHHHCHHHHHC	35.38	25619855
36	Phosphorylation	QDNLFDVSTEEGPIK HCCCCCCCCCCCCCC	31.76	25619855
37	Phosphorylation	DNLFDVSTEEGPIKR CCCCCCCCCCCCCCC	37.59	25619855
165	Phosphorylation	VTESGKKSVKLSVNP CCCCCCEEEEEECCH	28.15	28066266
169	Phosphorylation	GKKSVKLSVNPKRVN CCEEEEEECCHHHHH	17.71	28066266
344	Phosphorylation	RTRVVRLSLRPIFLH CCCEEEEECEEEECC	16.27	24704852
424	Phosphorylation	HKCRIIDYSQMDELA CEEEEECHHHCCHHH	7.15	28507225
434	Phosphorylation	MDELALLSLRKSIIA CCHHHHHHHHHHHHH	27.29	22324799
438	Phosphorylation	ALLSLRKSIIAAPFL HHHHHHHHHHHHHHH	16.88	29514104
482	Phosphorylation	QIKGLVPSMHLADIM HHCCCCCHHHHHHHH	16.03	22802335
504	Acetylation	YSPGDEVKCRVLLCD CCCCCCCEEEEEEEC	17.80	7720465
528	Phosphorylation	LKKTLVTSKLSLITC HHHHHHHCCHHHHEE	24.91	20469934
531	Phosphorylation	TLVTSKLSLITCYEG HHHHCCHHHHEECCC	22.82	22817900
534	Phosphorylation	TSKLSLITCYEGAKP HCCHHHHEECCCCCC	17.83	20469934
536	Phosphorylation	KLSLITCYEGAKPGL CHHHHEECCCCCCCC	14.56	22817900
545	Phosphorylation	GAKPGLQTHGVIIRV CCCCCCCCCCEEEEE	26.16	22817900
609	Phosphorylation	SKERMLLSFRLLSDS CHHHHHHEEEECCCC	12.35	25367039
626	Phosphorylation	KDPGVESSQKKTGAV CCCCCCCCCCCCCCE	32.29	-
696	Phosphorylation	LHRVLCLSQSERHIL HHHHHHCCCCCCEEE	30.57	23737553
698	Phosphorylation	RVLCLSQSERHILLC HHHHCCCCCCEEEEE	32.97	23737553
784	Phosphorylation	QTVVAKVTNVDESKQ CEEEEEEECCCHHHH	28.90	-
789	Phosphorylation	KVTNVDESKQRMLLS EEECCCHHHHHHEEE	29.62	-
1035	Phosphorylation	EKEEENLTVKSKKRH HHHHCCCCHHCCCCC	37.15	25619855
1038	Phosphorylation	EENLTVKSKKRHSLA HCCCCHHCCCCCEEE	38.79	25619855
1043	Phosphorylation	VKSKKRHSLAIGDKV HHCCCCCEEECCCCC	24.43	28507225
1087	Phosphorylation	LDDVPVGTSPTTTLK CCCCCCCCCCCCCCC	31.59	21454597
1088	Phosphorylation	DDVPVGTSPTTTLKA CCCCCCCCCCCCCCC	17.83	21454597
1092	Phosphorylation	VGTSPTTTLKAGKKV CCCCCCCCCCCCCEE	28.83	21454597
1139	Phosphorylation	RPSELKGSYSALNTH CHHHHCCCHHCCCCC	17.83	30635358
1140	Phosphorylation	PSELKGSYSALNTHS HHHHCCCHHCCCCCC	13.46	30635358
1141	Phosphorylation	SELKGSYSALNTHSE HHHCCCHHCCCCCCC	28.16	30635358
1145	Phosphorylation	GSYSALNTHSESPVE CCHHCCCCCCCCHHH	27.85	28066266
1147	Phosphorylation	YSALNTHSESPVEKI HHCCCCCCCCHHHHH	37.42	28066266
1149	Phosphorylation	ALNTHSESPVEKIRQ CCCCCCCCHHHHHHH	36.94	28066266
1229	S-nitrosocysteine	DVPRAFLCLSLIGPY CCCCHHHHHHHHCCC	1.64	-
1229	S-nitrosylation	DVPRAFLCLSLIGPY CCCCHHHHHHHHCCC	1.64	20925432
1299	Phosphorylation	VRCYILSTAHRVLAL HHHHHHHHHHHHHHH	24.04	21454597
1307	Phosphorylation	AHRVLALSLRSSRTN HHHHHHHHHHCCCCC	19.01	21454597
1328	Phosphorylation	IEDPEINSIEDVKEG CCCCCCCCCCHHHCC	32.77	22817900
1409	Phosphorylation	IELSLLPSDTGRPDV EEEECCCCCCCCCCC	48.01	23984901
1411	Phosphorylation	LSLLPSDTGRPDVFS EECCCCCCCCCCCCC	39.15	25159016
1418	Phosphorylation	TGRPDVFSPAPEPKQ CCCCCCCCCCCCCCC	21.72	25159016
1468	Phosphorylation	GKRERQESESEQELV CHHHHHCCHHHHHHH	37.78	27087446
1470	Phosphorylation	RERQESESEQELVNK HHHHCCHHHHHHHHC	54.59	25521595
1482	Phosphorylation	VNKRPKKSGAAEEDD HHCCCCCCCCCCCCC	39.53	25619855
1490	Phosphorylation	GAAEEDDSGVEVYYR CCCCCCCCCCEEEEE	57.99	25521595
1495	Phosphorylation	DDSGVEVYYREGEDE CCCCCEEEEEECCCC	5.36	28833060
1496	Phosphorylation	DSGVEVYYREGEDEV CCCCEEEEEECCCCC	13.83	28833060
1537	Phosphorylation	LWDVGLDSLTPALPL EEECCCCCCCCCCCC	38.90	26643407
1539	Phosphorylation	DVGLDSLTPALPLRE ECCCCCCCCCCCCCC	15.52	26643407
1548	Phosphorylation	ALPLREESSDSEDEQ CCCCCCCCCCCCCCC	34.39	26643407
1549	Phosphorylation	LPLREESSDSEDEQP CCCCCCCCCCCCCCC	48.73	26643407
1551	Phosphorylation	LREESSDSEDEQPHQ CCCCCCCCCCCCCHH	49.23	26643407
1641	Phosphorylation	ERALKTISFREEQEK HHHHHHCCCHHHHHH	24.39	24719451
1698	Phosphorylation	IYTKSEKYKEAGELY HHCCCHHHHHHHHHH	15.26	27357545
1705	Phosphorylation	YKEAGELYNRMLKRF HHHHHHHHHHHHHHH	9.09	27357545
1722	Phosphorylation	EKAVWIKYGAFVLGR HHCCEEEECEEHHCC	12.45	22817900
1730	Phosphorylation	GAFVLGRSQAGASHR CEEHHCCCCCCCHHH	23.68	21183079
1857	Phosphorylation	LEYVEAKSSALED-- HHHHHHHHHHCCC--	28.08	24759943
1858	Phosphorylation	EYVEAKSSALED--- HHHHHHHHHCCC---	35.85	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RRP5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRP5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRP5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RRP5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.