NPA1P_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPA1P_MOUSE
• UniProt AC: Q571H0
• Protein Name: Nucleolar pre-ribosomal-associated protein 1
• Gene Name: Urb1
• Organism: Mus musculus (Mouse).
• Sequence Length: 2274
• Subcellular Localization: Nucleus, nucleolus.
• Protein Sequence: MGVPKRKASEGPSSAASPAGTVKRTRAEEFTGVRFKTLLKDAQGPGPALEAFVSAAKKLPQEDMCDVVEGYIKISMECAEIFQLLSGEKRPESEMLLIFQAFEAILLRTASDLTHFHVVGANIVKKLLYNHMKLLCESLYASGYRMARACLDLMTAMVTQGPEAARDVCSSLDLNKKALFALVTKRDSKGVHDVRLAYIQFALSFLIAGDDNTIGQVLEIKEFIPCIFSSGIKEDKISTINILLSTLKTKVIHNKNITKTQKVRFFTGQFLNHIAALYNWNGITDVTPEKPEISAEEAGKAMVRDLVHNFLMDLCCSRKHGISFYDASLGTSGRGGNLTLLHFLLSLKTAAGDDLVASLVVSILKVCPDLLTKYFKEVTFSFLPRVKSTWLNNVKLLNKIYEAQPEISPAFWTREFIPLPRLLAMVMVTTVPLVCNKIMFTQALNLDSIPVKHSALSLISDILKRALKTVDHCLDKETWQDSDVYTAEMMEEFVQLFREALGKILPDLNTVIWVWQSFKKQEIKEDHEKGKKSSSKTPAVSKAAQHDVAETILLKSVLLQVICLYQQVVPHVIMQYNFDFSKLLKGIISEQGPSQEVPPILQHHMLKVALELPANKFLWLKAQEGPEAEIIGGERSVFYLLMKMFVNSNHLQLKSSTKLLIMKILRDTGVFEHTWRELELWLEHLDSTAEERKEAVIQFLERILLTLVMNPYSYTDKASEFVQEASTLQASMGKQDADDVSIPISHIDDVLDMVDVLVEGSEGLDEDIGFLLNEDMILLTFPFSALVPAALEARNKLLLGTDCEAGESIMAYMTAVLTDLLHTQRDPLALCLLLQSYDKFEPVSLLCGQQLAQFHRYYSLWIPAQAQEALPLQVSSSSGPCTLPPSSCFSTLLQTAYESQTLGDKSVQAQLLAAVPSLALQHMLRSAKQVLLYLKSTVENFSQLGRSVGPALLQSLLGLLKQLVIHAERLDAQNQQKLEAARAESDLFLDMESVASLELATDKTIEELLLAILKHPTLETWFLALEQKALPPHTLSPILVKLLAAHFSAGVLQLLVASSPILHKLGQLGLLAKYSEAITQSVLIELRTRTLNSTSTPKTLPQLEALRELHPYMEGVQIREVTLALLALPEAHLLTQQGTQSLGKERHLSSLGKTLVQLLASSHQDQLQSSELLWCAEYVRGLGALLPTLAEHELDTVFLQTLQKDPVLAPVVPEGVLEYCLARRTQTALGIASLLLQYSGTHLVKFELWCGQPGVGPTLQEHLDDFFPLIHVYLQHRAQGSFMRPTGVSSAVTPVLKALWRQVRDRFFHITGPSKDALHLEALAQLIPFARTKDLHVLMDHLPNTLRTLSNHKSWTLADSVSAALAESAEELGSWRKTLLRSCIQWLAVSFSGREPEDENTQEHEKAMLVRLSELLHAVKEVDPGDWQQFVKTGLKFRYHDLTFLKTLLSATKLLYGPESSGRTKLVQLSVVHMMLTQHSLFLPTMLSSEEEETPDSGVKETLLDLMSTVVRLCPSVCQSSHFAVLLGTYSATLSVLDQKILLLLRAYEQNNLSLISFRVLLWGPAAVEHHKTCRSLGKSLWQQPSVGDILRLLDPDRMMQTILHFPQYRKLLPTEDTGEPLVFKDKTARVDLDSLYDPCFLLHLFGELTRPEFVVDCRKFLDSNALGLTVAALSSYDPQMRAAAYYVLAAYYSHLEGARFREQSQVLYLLDVVRNGIRTPNLRLPFTVALFIAKAAVQILKPEEHMYWKISKFLLSHENLNMDKLPGFYQFFYSSDFQQKTEQEWVLEILRQGIRDKHCYELCSRRGVFHIILSFFNSPLCDEVAQNWILEILQNVAHITRSAYEVIRDYSLLTWVLHILESRFVETQLLSNVISLLHTLWVTNLGNKAPEERSQPPGQVGSQESEKMLALHMVSEFLYVLIALTKHLRPTLASAQLMNFFWTLESVLSYRATIIKLFKDMGRFTVNKVALSTKDVLILLHKWSLIERDTKLQGELKAVIEQHQAKDLMKMLKDKSRPVVAAQARGPRGRKRRHGGLEETAEPQLEASCLEKCKDLLRATLTHWGPGDPLPGPTQGSVGQTIPKSKTLSSAHAAVSLVASWVLRSLAERPVSRAEVTRLLDWLKSHILPQPMVVADLLGDSAVKTGIFKLYNHHCSAQGLVGPAQDVACKFSTVMLQLLVAQGRKESPFHSVAEALCLDSLNEKEEAKRAPAAFLVSLYVKDMWLGAQQPDTFLAHIRMVCEAAKDVPLDEPEAIVVLCRNVDSSAQCLTRSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GVPKRKASEGPSSAA CCCCCCCCCCCCCCC	46.23	29514104
13	Phosphorylation	RKASEGPSSAASPAG CCCCCCCCCCCCCCC	43.39	25159016
14	Phosphorylation	KASEGPSSAASPAGT CCCCCCCCCCCCCCC	30.87	28066266
17	Phosphorylation	EGPSSAASPAGTVKR CCCCCCCCCCCCCCC	18.26	25159016
21	Phosphorylation	SAASPAGTVKRTRAE CCCCCCCCCCCCCHH	25.59	28066266
319	Malonylation	MDLCCSRKHGISFYD HHHHHHCCCCCEEEE	29.86	26320211
535	Phosphorylation	EKGKKSSSKTPAVSK HHCCCCCCCCHHHHH	47.87	19367708
1141	Phosphorylation	LTQQGTQSLGKERHL HHCHHHHHHCCHHHH	38.64	-
1377	Acetylation	EELGSWRKTLLRSCI HHHCHHHHHHHHHHH	36.95	2382953
1450	Phosphorylation	TFLKTLLSATKLLYG HHHHHHHHHHHHHHC	36.68	-
1452	Phosphorylation	LKTLLSATKLLYGPE HHHHHHHHHHHHCCC	20.89	-
1470	Phosphorylation	RTKLVQLSVVHMMLT CCHHHHHHHHHHHHH	12.66	-
1670	Phosphorylation	DSNALGLTVAALSSY CCCCCCCHHHHHHCC	13.29	-
1677	Phosphorylation	TVAALSSYDPQMRAA HHHHHHCCCHHHHHH	28.41	-
1687	Phosphorylation	QMRAAAYYVLAAYYS HHHHHHHHHHHHHHH	5.58	-
1895	Phosphorylation	NKAPEERSQPPGQVG CCCCHHHCCCCCCCC	50.77	23375375
1903	Phosphorylation	QPPGQVGSQESEKML CCCCCCCCHHHHHHH	31.73	23375375
1906	Phosphorylation	GQVGSQESEKMLALH CCCCCHHHHHHHHHH	34.57	23375375
1944	Phosphorylation	QLMNFFWTLESVLSY HHHHHHHHHHHHHHH	18.58	28576409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPA1P_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPA1P_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPA1P_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NPA1P_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.