NOL6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOL6_MOUSE
• UniProt AC: Q8R5K4
• Protein Name: Nucleolar protein 6
• Gene Name: Nol6
• Organism: Mus musculus (Mouse).
• Sequence Length: 1152
• Subcellular Localization: Nucleus, nucleolus . Chromosome . Localizes to condensed chromosomes in mitosis.
• Protein Sequence: MPSAGERPAVKMGPAPAGEQHRRATEDPEVMELAFEGMDKEKAPSRKRARTEPPAEGLLQPVNLSREELYKEPTNEELNRLRETEILFHSTLLRLQVEELLKEVRLSEKKKERIDNFLKEVTKRIQKVPPVPEAELTDQSWLPAGVRVPLHQVPYAVKGSFRFRPPSQITVVGSYLLDTCMRPDINVDVAVTMPREILQDKDGLNQRYFRKRALYLAHLAYHLAQDPLFSSVRFSYMSGCHLKPSLLLRPHGKDERLVTVRLLPCPPLDFFRPCRLLPTKNNVRSAWYRGQSCPDYEPPTPHYNTWILQDVALETHMHLLASVLGSAQGLKDGVALLKVWLRQRELDKGLGGFNGFIISMLVAFLVSKRKIHTTMSGYQVLRSVLQFLATTDLTINGISFSLSSDPSLPTLAEFHQLFAVVFVDPSGRLNLCADVTASTYNQVQYEAELSMALLDSKADDGFQLLLMTPKPMIQAFDHVVHLHPLSRLQASCHQLKLWPELQDNGGDYVSAALGPLTNILVQGLGCRLHLLAHSRPPVPEWSINQDPPKHKDAGTLTLGFLFRPEGLTSVIDLGPEADKPEAADFRQFWGTRSELRRFQDGAIREAVVWEAESLFEKRLIPHQVVTHLLALHADIPDTCIQYVGGFLDALIQNPKEISSTGEEALALAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPAPVRPAYSFYNRLQELASLLPRPDKPCPAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAEVLTQEHRLQCCATATHTDVLKDGFVFRIRVAYQREPQILKEVRSPEGMVSLRDTPASLRLERDTKLLPLLTSALHGLQQQYPAYSGVARLAKRWVRAQLLGEGFTDESLDLLAASLFLHPEPFTPPSVPQVGFLRFLYLVSTFDWKNNPLIVNLNGELTAEEQVGIRSSFLAARTQLPVMVIITPQDRRSSVWTQDGPSAQILQQLVSLAAEALPILEKQLMDPRGPGDIRTVFRPPFDMYDVLIHLTPRHIPRHRQAVDPPVASFCRGLLAEPGPSSLMPVLGYDPPQLYLAQLREAFEDLALFFYDQHGGEVIGVLWKPSSFQPQPFKASSIKGRMVVSQGGELVMLPNIEAILEDFAVLGEGLVQAVEARSERWTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	LLQPVNLSREELYKE CCCCCCCCHHHHHCC	32.23	-
71	Ubiquitination	LSREELYKEPTNEEL CCHHHHHCCCCHHHH	70.60	22790023
158	Ubiquitination	HQVPYAVKGSFRFRP HHCCEEEEECEECCC	40.44	22790023
167	Phosphorylation	SFRFRPPSQITVVGS CEECCCHHHEEEEEE	36.58	-
179	Phosphorylation	VGSYLLDTCMRPDIN EEEEHHHHHCCCCCC	14.26	-
201	Ubiquitination	PREILQDKDGLNQRY CHHHHCCCCCCCHHH	40.51	22790023
292	Phosphorylation	SAWYRGQSCPDYEPP CHHHCCCCCCCCCCC	30.37	-
438	Phosphorylation	LCADVTASTYNQVQY EEEECCHHHCCHHHH	23.27	22871156
439	Phosphorylation	CADVTASTYNQVQYE EEECCHHHCCHHHHH	24.83	22871156
817	Phosphorylation	QILKEVRSPEGMVSL HHHHHCCCCCCCCCC	32.26	28066266
823	Phosphorylation	RSPEGMVSLRDTPAS CCCCCCCCCCCCCCH	14.59	-
838	Ubiquitination	LRLERDTKLLPLLTS HCCCCHHCHHHHHHH	52.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOL6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOL6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOL6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NOL6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.