PP2AA_MOUSE - dbPTM
PP2AA_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PP2AA_MOUSE
UniProt AC P63330
Protein Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Gene Name Ppp2ca
Organism Mus musculus (Mouse).
Sequence Length 309
Subcellular Localization Cytoplasm . Nucleus. Chromosome, centromere . Cytoplasm, cytoskeleton, spindle pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity). Centromeric localization req
Protein Description PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity)..
Protein Sequence MDEKLFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8UbiquitinationMDEKLFTKELDQWIE
CCHHHHHHHHHHHHH		49.2822790023
20S-nitrosocysteineWIEQLNECKQLSESQ
HHHHHHHHHHCCHHH		3.11-
20S-nitrosylationWIEQLNECKQLSESQ
HHHHHHHHHHCCHHH		3.1121278135
21UbiquitinationIEQLNECKQLSESQV
HHHHHHHHHCCHHHH		48.3622790023
26PhosphorylationECKQLSESQVKSLCE
HHHHCCHHHHHHHHH		36.5829899451
29UbiquitinationQLSESQVKSLCEKAK
HCCHHHHHHHHHHHH		30.0322790023
41AcetylationKAKEILTKESNVQEV
HHHHHHHCCCCCCEE		56.5566701715
41UbiquitinationKAKEILTKESNVQEV
HHHHHHHCCCCCCEE		56.5522790023
74UbiquitinationELFRIGGKSPDTNYL
HHHHCCCCCCCCCEE		54.3122790023
127PhosphorylationSRQITQVYGFYDECL
HHHHHEEEEHHHHHH		7.5322817900
136UbiquitinationFYDECLRKYGNANVW
HHHHHHHHHCCCCHH		44.5622790023
196S-nitrosocysteineVPHEGPMCDLLWSDP
CCCCCCCCCEECCCC		3.62-
196S-nitrosylationVPHEGPMCDLLWSDP
CCCCCCCCCEECCCC		3.6221278135
196GlutathionylationVPHEGPMCDLLWSDP
CCCCCCCCCEECCCC		3.6224333276
212PhosphorylationDRGGWGISPRGAGYT
CCCCCCCCCCCCCCC		12.4722006019
251S-nitrosocysteineVMEGYNWCHDRNVVT
HHCCCCCCCCCCEEE		1.81-
251S-nitrosylationVMEGYNWCHDRNVVT
HHCCCCCCCCCCEEE		1.8121278135
251GlutathionylationVMEGYNWCHDRNVVT
HHCCCCCCCCCCEEE		1.8124333276
266S-nitrosocysteineIFSAPNYCYRCGNQA
EEECCCCHHHCCCEE		1.88-
266S-nitrosylationIFSAPNYCYRCGNQA
EEECCCCHHHCCCEE		1.8821278135
266GlutathionylationIFSAPNYCYRCGNQA
EEECCCCHHHCCCEE		1.8824333276
269S-nitrosylationAPNYCYRCGNQAAIM
CCCCHHHCCCEEEEE		2.1321278135
269S-nitrosocysteineAPNYCYRCGNQAAIM
CCCCHHHCCCEEEEE		2.13-
283UbiquitinationMELDDTLKYSFLQFD
EECCCCCEEEEEECC		40.72-
284NitrationELDDTLKYSFLQFDP
ECCCCCEEEEEECCC		14.04-
284PhosphorylationELDDTLKYSFLQFDP
ECCCCCEEEEEECCC		14.0422817900
285PhosphorylationLDDTLKYSFLQFDPA
CCCCCEEEEEECCCC		20.2128464351
304PhosphorylationEPHVTRRTPDYFL--
CCCCCCCCCCCCC--		19.7427180971
307PhosphorylationVTRRTPDYFL-----
CCCCCCCCCC-----		14.1622729898
309MethylationRRTPDYFL-------
CCCCCCCC-------		5.8110441131
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
307YPhosphorylationKinaseLYNP25911
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PP2AA_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PP2AA_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ROA2_MOUSEHnrnpa2b1physical
16170352
H11_MOUSEHist1h1aphysical
16170352
AXIN1_MOUSEAxin1physical
9920888
2AAA_MOUSEPpp2r1aphysical
9920888
HDAC4_MOUSEHdac4physical
22466704
ERN2_MOUSEErn2physical
23942232
KCD20_MOUSEKctd20physical
24156551
UNC5B_MOUSEUnc5bphysical
21172653
TCPZ_HUMANCCT6Aphysical
26496610
HELLS_HUMANHELLSphysical
26496610
IGBP1_HUMANIGBP1physical
26496610
PRIC3_HUMANPRICKLE3physical
26496610
2AAA_HUMANPPP2R1Aphysical
26496610
2AAB_HUMANPPP2R1Bphysical
26496610
2A5D_HUMANPPP2R5Dphysical
26496610
SSRG_HUMANSSR3physical
26496610
STRN_HUMANSTRNphysical
26496610
TCPA_HUMANTCP1physical
26496610
TCPG_HUMANCCT3physical
26496610
SLMAP_HUMANSLMAPphysical
26496610
CCDC6_HUMANCCDC6physical
26496610
LIPA1_HUMANPPFIA1physical
26496610
ATPK_HUMANATP5J2physical
26496610
US6NL_HUMANUSP6NLphysical
26496610
KEAP1_HUMANKEAP1physical
26496610
PP4R1_HUMANPPP4R1physical
26496610
TCPH_HUMANCCT7physical
26496610
TCPD_HUMANCCT4physical
26496610
TCPB_HUMANCCT2physical
26496610
TCPQ_HUMANCCT8physical
26496610
ZMY11_HUMANZMYND11physical
26496610
RPP29_HUMANPOP4physical
26496610
TCPE_HUMANCCT5physical
26496610
CIC_HUMANCICphysical
26496610
PHOCN_HUMANMOB4physical
26496610
SENP6_HUMANSENP6physical
26496610
FGOP2_HUMANFGFR1OP2physical
26496610
INT6_HUMANINTS6physical
26496610
RM22_HUMANMRPL22physical
26496610
STRN4_HUMANSTRN4physical
26496610
STRN3_HUMANSTRN3physical
26496610
RT07_HUMANMRPS7physical
26496610
S18L2_HUMANSS18L2physical
26496610
STK26_HUMANSTK26physical
26496610
INT11_HUMANCPSF3Lphysical
26496610
CT2NL_HUMANCTTNBP2NLphysical
26496610
INT12_HUMANINTS12physical
26496610
FANCM_HUMANFANCMphysical
26496610
TFB2M_HUMANTFB2Mphysical
26496610
TM109_HUMANTMEM109physical
26496610
CDC73_HUMANCDC73physical
26496610
SIKE1_HUMANSIKE1physical
26496610
ZFP91_HUMANZFP91physical
26496610
ZCHC9_HUMANZCCHC9physical
26496610
ING5_HUMANING5physical
26496610
TRIM5_HUMANTRIM5physical
26496610
STRP1_HUMANSTRIP1physical
26496610
ERI1_HUMANERI1physical
26496610
INT4_HUMANINTS4physical
26496610
CA131_HUMANC1orf131physical
26496610
LSM11_HUMANLSM11physical
26496610
INT1_HUMANINTS1physical
26496610
CEBPA_MOUSECebpaphysical
15107404
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PP2AA_MOUSE

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Related Literatures of Post-Translational Modification

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