SNUT2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNUT2_MOUSE
• UniProt AC: Q3TIX9
• Protein Name: U4/U6.U5 tri-snRNP-associated protein 2
• Gene Name: Usp39
• Organism: Mus musculus (Mouse).
• Sequence Length: 564
• Subcellular Localization: Nucleus.
• Protein Description: Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs) (By similarity)..
• Protein Sequence: MSSRSKRQSHGSTRGKRESESRGSSGRIKKERDREKEPEAASSRGSPVRVKREAEPAAREVPAPALPVVRVKREREADEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDFEKLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEIIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVNDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	SSRSKRQSHGSTRGK CCHHHHHCCCCCCCC	33.57	24719451
12	Phosphorylation	SKRQSHGSTRGKRES HHHHCCCCCCCCCHH	14.98	24719451
13	Phosphorylation	KRQSHGSTRGKRESE HHHCCCCCCCCCHHH	48.29	24719451
42	Phosphorylation	EKEPEAASSRGSPVR HCCHHHHHHCCCCCE	27.84	23684622
43	Phosphorylation	KEPEAASSRGSPVRV CCHHHHHHCCCCCEE	35.61	23684622
46	Phosphorylation	EAASSRGSPVRVKRE HHHHHCCCCCEECCC	21.07	25521595
72	Sumoylation	ALPVVRVKREREADE CCCEEEEEEHHHCCC	37.67	28289178
81	Phosphorylation	EREADEDSEPEREVR HHHCCCCCCCHHHHH	53.67	27087446
96	Phosphorylation	AKNGRVDSEDRRSRH HHCCCCCCHHHHHCC	38.24	29899451
294	Phosphorylation	RNFKAHVSPHEMLQA CCCCCCCCHHHHHHH	15.63	-
342	Phosphorylation	GTKKKKKTIVNDVFQ CCCCCCCCEECHHHC	38.75	24723360
351	Phosphorylation	VNDVFQGSMRIFTKK ECHHHCCCHHHHCCC	8.29	24723360

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNUT2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNUT2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNUT2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SNUT2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.