TF7L2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF7L2_MOUSE
• UniProt AC: Q924A0
• Protein Name: Transcription factor 7-like 2
• Gene Name: Tcf7l2
• Organism: Mus musculus (Mouse).
• Sequence Length: 459
• Subcellular Localization: Nucleus, PML body. Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies (By similarity)..
• Protein Description: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine..
• Protein Sequence: MPQLNGGGGDDLGANDELISFKDEGEQEEKNSENSSAERDLADVKSSLVNESETNQDSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGSLSPTARTYLQMKWPLLDVQAGSLQSRQTLKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	GANDELISFKDEGEQ CCCCCEEECCCCCHH	38.58	25338131
32	Phosphorylation	GEQEEKNSENSSAER CHHHHHHCCCCHHHH	49.58	29550500
35	Phosphorylation	EEKNSENSSAERDLA HHHHCCCCHHHHHHH	27.20	29550500
36	Phosphorylation	EKNSENSSAERDLAD HHHCCCCHHHHHHHH	45.81	29550500
46	Phosphorylation	RDLADVKSSLVNESE HHHHHHHHHHHCCCC	28.84	27087446
60	Phosphorylation	ETNQDSSSDSEAERR CCCCCCCCCCHHHHC	49.46	27087446
62	Phosphorylation	NQDSSSDSEAERRPP CCCCCCCCHHHHCCC	40.43	27087446
82	Phosphorylation	FRDKSRESLEEAAKR HHHHHHHHHHHHHHH	39.71	29550500
122	Phosphorylation	YLPNGSLSPTARTYL CCCCCCCCCCHHHHH	23.15	27180971
154	Phosphorylation	QTLKDARSPSPAHIV HHHHHCCCCCHHHHH	31.30	27087446
156	Phosphorylation	LKDARSPSPAHIVSN HHHCCCCCHHHHHCC	35.65	27087446
162	Phosphorylation	PSPAHIVSNKVPVVQ CCHHHHHCCCCCCCC	30.26	25777480
178	Phosphorylation	PHHVHPLTPLITYSN CCCCCCCCCEEEECC	22.09	-
189	Phosphorylation	TYSNEHFTPGNPPPH EECCCCCCCCCCCCC	31.99	-
297	Sumoylation	AIVTPTVKQESSQSD CEECCCCCCCCCCCC	51.32	-
369	Phosphorylation	GRRWHALSREEQAKY HHHHHHCCHHHHHHH	38.13	-
376	Phosphorylation	SREEQAKYYELARKE CHHHHHHHHHHHHHH	12.75	29895711
377	Phosphorylation	REEQAKYYELARKER HHHHHHHHHHHHHHH	12.08	-
436 (in isoform 8)	Phosphorylation	-	45.39	28285833
442 (in isoform 8)	Phosphorylation	-	37.36	28285833
510 (in isoform 4)	Phosphorylation	-		25777480
512 (in isoform 4)	Phosphorylation	-		25777480
515 (in isoform 4)	Phosphorylation	-		25777480
519 (in isoform 4)	Phosphorylation	-		25777480
521 (in isoform 4)	Phosphorylation	-		25777480
531 (in isoform 4)	Phosphorylation	-		25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
178	T	Phosphorylation	Kinase	NLK	O54949	Uniprot
189	T	Phosphorylation	Kinase	NLK	O54949	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
178	T	Phosphorylation	Phosphorylated at Thr-178 and/or Thr-189 by NLK.	-
189	T	Phosphorylation	Phosphorylated at Thr-178 and/or Thr-189 by NLK.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF7L2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNF4A_MOUSE	Hnf4a	physical	19805521
CTNB1_MOUSE	Ctnnb1	physical	19503085
HDAC1_MOUSE	Hdac1	physical	19503085
HDAC2_MOUSE	Hdac2	physical	19503085
EP300_HUMAN	EP300	genetic	12861022

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.