dbPTM

NOP58_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOP58_MOUSE
UniProt AC	Q6DFW4
Protein Name	Nucleolar protein 58
Gene Name	Nop58
Organism	Mus musculus (Mouse).
Sequence Length	536
Subcellular Localization	Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein Description	Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity)..
Protein Sequence	MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASASLSEFLSEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQSSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGIENRAKLEARLRILEDRGIRKISGTGKALAKAEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEEVDKEDEITEKKAKKAKIKIKAEVEEEMEEEEAEEEQVVEEEPTVKKKKKKDKKKHIKEEPLSEEEPCTSTAVPSPEKKKKKKKKKDAED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	SLWKEFETPEKANKI HHHHHCCCHHHHHHH	41.91	28066266
67	Acetylation	FTALMEGKINKQLKK HHHHHHCCHHHHHHH	29.78	23954790
70	Ubiquitination	LMEGKINKQLKKVLK HHHCCHHHHHHHHHH	61.55	-
81	Malonylation	KVLKKIVKEAHEPLA HHHHHHHHHHCCCHH	53.29	26320211
93	Malonylation	PLAVADAKLGGVIKE CHHHCCCCCCCHHHH	48.49	26320211
101	Malonylation	LGGVIKEKLNLSCIH CCCHHHHHCCCHHCC	37.36	26320211
105	Phosphorylation	IKEKLNLSCIHSPVV HHHHCCCHHCCHHHH	15.22	25159016
106	S-palmitoylation	KEKLNLSCIHSPVVN HHHCCCHHCCHHHHH	3.51	28526873
106	Glutathionylation	KEKLNLSCIHSPVVN HHHCCCHHCCHHHHH	3.51	24333276
109	Phosphorylation	LNLSCIHSPVVNELM CCCHHCCHHHHHHHH	10.24	25159016
121	Phosphorylation	ELMRGIRSQMDGLIP HHHHHHHHHHCCCCC	28.12	22817900
206	Ubiquitination	SDNLTYCKCLQKVGD HCCCHHHHHHHHHCC	27.80	22790023
217	Phosphorylation	KVGDRKNYASASLSE HHCCCCCHHHCHHHH	12.64	22802335
223	Phosphorylation	NYASASLSEFLSEEV CHHHCHHHHHHHHHH	24.65	22802335
304	Phosphorylation	RLIAHAGSLLNLAKH HHHHHHHHHHHHHHH	30.39	-
342	Phosphorylation	TPKYGLIYHASLVGQ CCCCEEEEEHHHCCC	9.07	25159016
345	Phosphorylation	YGLIYHASLVGQSSP CEEEEEHHHCCCCCC	15.41	25159016
350	Phosphorylation	HASLVGQSSPKHKGK EHHHCCCCCCCCCCH	42.55	26239621
351	Phosphorylation	ASLVGQSSPKHKGKI HHHCCCCCCCCCCHH	30.04	22942356
405	Acetylation	LEDRGIRKISGTGKA HHHCCCEECCCCCHH	39.02	6569155
407	Phosphorylation	DRGIRKISGTGKALA HCCCEECCCCCHHHH	33.08	29514104
409	Phosphorylation	GIRKISGTGKALAKA CCEECCCCCHHHHHH	28.81	-
411	Malonylation	RKISGTGKALAKAEK EECCCCCHHHHHHHH	39.81	26320211
411	Acetylation	RKISGTGKALAKAEK EECCCCCHHHHHHHH	39.81	6568357
419	Phosphorylation	ALAKAEKYEHKSEVK HHHHHHHCCCCCCCC	18.12	28576409
434	Phosphorylation	TYDPSGDSTLPTCSK EECCCCCCCCCCCCC	35.06	29176673
435	Phosphorylation	YDPSGDSTLPTCSKK ECCCCCCCCCCCCCC	41.31	29176673
438	Phosphorylation	SGDSTLPTCSKKRKI CCCCCCCCCCCCCCH	32.31	29176673
440	Phosphorylation	DSTLPTCSKKRKIEE CCCCCCCCCCCCHHH	43.63	29176673
441	Malonylation	STLPTCSKKRKIEEV CCCCCCCCCCCHHHC	59.76	26320211
441	Acetylation	STLPTCSKKRKIEEV CCCCCCCCCCCHHHC	59.76	133337
509	Phosphorylation	HIKEEPLSEEEPCTS CCCCCCCCCCCCCCC	54.39	27087446
515	Phosphorylation	LSEEEPCTSTAVPSP CCCCCCCCCCCCCCH	39.57	24925903
516	Phosphorylation	SEEEPCTSTAVPSPE CCCCCCCCCCCCCHH	22.53	24925903
517	Phosphorylation	EEEPCTSTAVPSPEK CCCCCCCCCCCCHHH	17.33	24925903
521	Phosphorylation	CTSTAVPSPEKKKKK CCCCCCCCHHHHHHH	38.81	24925903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NOP58_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOP58_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOP58_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NOP58_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOP58_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509 AND SER-521, ANDMASS SPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509 AND SER-521, ANDMASS SPECTROMETRY.	17242355 [Abstract]
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509 AND SER-521, ANDMASS SPECTROMETRY.	17203969 [Abstract]