FL2D_MOUSE - dbPTM
FL2D_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FL2D_MOUSE
UniProt AC Q9ER69
Protein Name Pre-mRNA-splicing regulator WTAP {ECO:0000305}
Gene Name Wtap {ECO:0000303|PubMed:11001926, ECO:0000312|MGI:MGI:1926395}
Organism Mus musculus (Mouse).
Sequence Length 396
Subcellular Localization Nucleus speckle . Nucleus, nucleoplasm . Cytoplasm . Mainly nuclear with some fraction located in the cytoplasm (PubMed:29547716). ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus (PubMed:29547716).
Protein Description Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. [PubMed: 29535189]
Protein Sequence MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKYTDLNSNDVTGLRESEEKLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLFFLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRIAQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKETRQQLAQYQQQQSQASAPSTSRTTSSEPVDQAEVTSKDCSRLANGPSNGSSSRQRTSGSGFHREGSTPEDDFPSSSGNGNKASNSSEERTGRGGSSYINPLSAGYESVDSPTGSENSLTHHSNDTDSSHDPQEEKAVSGKGNRTVGSRHVQNGLDSSVNVQGAVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MTNEEPLP
-------CCCCCCCC		9.07-
14PhosphorylationLPKKVRLSETDFKVM
CCCCCCCCCCCHHHE		28.0828066266
16PhosphorylationKKVRLSETDFKVMAR
CCCCCCCCCHHHEEC		43.2828066266
244PhosphorylationAQYQQQQSQASAPST
HHHHHHHHHHCCCCC		24.3128285833
252PhosphorylationQASAPSTSRTTSSEP
HHCCCCCCCCCCCCC		31.7828576409
254PhosphorylationSAPSTSRTTSSEPVD
CCCCCCCCCCCCCCC		30.6925619855
255PhosphorylationAPSTSRTTSSEPVDQ
CCCCCCCCCCCCCCC		29.1925619855
256PhosphorylationPSTSRTTSSEPVDQA
CCCCCCCCCCCCCCH		31.9022942356
257PhosphorylationSTSRTTSSEPVDQAE
CCCCCCCCCCCCCHH		43.7725619855
281PhosphorylationANGPSNGSSSRQRTS
HCCCCCCCCCCCCCC		29.4128285833
287PhosphorylationGSSSRQRTSGSGFHR
CCCCCCCCCCCCCCC		29.1522817900
288PhosphorylationSSSRQRTSGSGFHRE
CCCCCCCCCCCCCCC		32.9022817900
290PhosphorylationSRQRTSGSGFHREGS
CCCCCCCCCCCCCCC		37.7422817900
297PhosphorylationSGFHREGSTPEDDFP
CCCCCCCCCCCCCCC		35.7225521595
298PhosphorylationGFHREGSTPEDDFPS
CCCCCCCCCCCCCCC		41.3725619855
305PhosphorylationTPEDDFPSSSGNGNK
CCCCCCCCCCCCCCC		36.81-
306PhosphorylationPEDDFPSSSGNGNKA
CCCCCCCCCCCCCCC		42.37-
326PhosphorylationERTGRGGSSYINPLS
CCCCCCCCCCCCCCC		23.8525777480
327PhosphorylationRTGRGGSSYINPLSA
CCCCCCCCCCCCCCC		33.0525777480
328PhosphorylationTGRGGSSYINPLSAG
CCCCCCCCCCCCCCC		13.3525777480
333PhosphorylationSSYINPLSAGYESVD
CCCCCCCCCCCCCCC		22.3925777480
336PhosphorylationINPLSAGYESVDSPT
CCCCCCCCCCCCCCC		12.5422817900
338PhosphorylationPLSAGYESVDSPTGS
CCCCCCCCCCCCCCC		23.8122817900
341PhosphorylationAGYESVDSPTGSENS
CCCCCCCCCCCCCCC		23.3922817900
343PhosphorylationYESVDSPTGSENSLT
CCCCCCCCCCCCCCC		58.2425777480
345PhosphorylationSVDSPTGSENSLTHH
CCCCCCCCCCCCCCC		35.7621183079
348PhosphorylationSPTGSENSLTHHSND
CCCCCCCCCCCCCCC		30.5022817900
350PhosphorylationTGSENSLTHHSNDTD
CCCCCCCCCCCCCCC		19.8422817900
353PhosphorylationENSLTHHSNDTDSSH
CCCCCCCCCCCCCCC		28.8825777480
356PhosphorylationLTHHSNDTDSSHDPQ
CCCCCCCCCCCCCHH		41.8725777480
358PhosphorylationHHSNDTDSSHDPQEE
CCCCCCCCCCCHHHH		31.5025777480
359PhosphorylationHSNDTDSSHDPQEEK
CCCCCCCCCCHHHHH		34.4225777480
388PhosphorylationVQNGLDSSVNVQGAV
HHCCCCCCEECCCCC		19.85-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FL2D_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FL2D_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FL2D_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FL2D_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FL2D_MOUSE

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Related Literatures of Post-Translational Modification

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