NUP93_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUP93_MOUSE
• UniProt AC: Q8BJ71
• Protein Name: Nuclear pore complex protein Nup93
• Gene Name: Nup93
• Organism: Mus musculus (Mouse).
• Sequence Length: 819
• Subcellular Localization: Nucleus membrane ; Peripheral membrane protein . Nucleus, nuclear pore complex . Nucleus envelope . Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore..
• Protein Description: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC (By similarity). During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (By similarity). [PubMed: 26878725]
• Protein Sequence: MDTEGFGELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKASVLLGSRGLDISHISQRLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKRTFGMAEEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQESEPSYIGDVNPPGRSSLDSIEMAYARQIYIYNEKIVSGHLQPNLVDLCASVAELDDKSISDMWAMVKQMTDVVLTPATDALKSRSSVEVRMDFVKQALGYLEQSYKNYTLVTVFGNLHQAQLGGVPGTYQLVRSFLNIKLPAPSPGLQDGEVEGHPVWALIYYCMRCGDLLAASQVVSRAQHQLGEFKTWFQEYMNSKDRRLSPATENKLRLHYRRALRNNTDPYKRAVYCIIGRCDITDNQSEVADKTEDYLWLKLNQVCFDDDGTSSPQDRLTLSQFQKQLLEDYGESHFTVNQQPFLYFQVLFLTAQFEAAIAFLFRMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGDPPCMRRLNFVRLLMLYTRKFESTDPREALQYFYFLRDEKDSQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVIDKFTSDTKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNKERLKNMALSIAERYRAQGISANKFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIDRLKLVPLNQESVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSSATRPQRVIEDRDSQLRSQARALITFAGMIPYRTSGDTNARLVQMEVLMN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDTEGFGELL -----CCCCHHHHHH	36.39	26239621
20	Phosphorylation	AEQLAAETEGISELP HHHHHHHCCCHHHCH	34.48	26239621
47	Phosphorylation	GERLRSRTLTRTSQE HHHHHHHCCCCCCHH	33.46	28833060
49	Phosphorylation	RLRSRTLTRTSQETA HHHHHCCCCCCHHHH	31.15	22942356
51	Phosphorylation	RSRTLTRTSQETADV HHHCCCCCCHHHHHH	29.53	22802335
52	Phosphorylation	SRTLTRTSQETADVK HHCCCCCCHHHHHHH	23.80	26824392
55	Phosphorylation	LTRTSQETADVKASV CCCCCHHHHHHHHHH	22.11	28833060
59	Ubiquitination	SQETADVKASVLLGS CHHHHHHHHHHHHCC	35.18	22790023
66	Phosphorylation	KASVLLGSRGLDISH HHHHHHCCCCCCHHH	24.12	28066266
72	Phosphorylation	GSRGLDISHISQRLE CCCCCCHHHHHHHHH	17.90	22817900
75	Phosphorylation	GLDISHISQRLESLS CCCHHHHHHHHHHHH	12.11	22817900
80	Phosphorylation	HISQRLESLSAATTF HHHHHHHHHHCCCCC	32.01	26824392
82	Phosphorylation	SQRLESLSAATTFEP HHHHHHHHCCCCCCC	25.74	18846507
94	Ubiquitination	FEPLEPVKDTDIQGF CCCCCCCCCCCCCHH	66.67	22790023
103	Acetylation	TDIQGFLKNEKDNAL CCCCHHHHCHHHHHH	61.88	23236377
106	Acetylation	QGFLKNEKDNALLSA CHHHHCHHHHHHHHH	66.72	23806337
112	Phosphorylation	EKDNALLSAIEESRK HHHHHHHHHHHHHHH	28.22	25338131
120	Ubiquitination	AIEESRKRTFGMAEE HHHHHHHHHCCCHHH	33.89	27667366
165	Phosphorylation	FTQESEPSYIGDVNP CCCCCCCCCCCCCCC	25.90	24224561
166	Phosphorylation	TQESEPSYIGDVNPP CCCCCCCCCCCCCCC	21.46	25159016
176	Phosphorylation	DVNPPGRSSLDSIEM CCCCCCCCCHHHHHH	40.96	28833060
177	Phosphorylation	VNPPGRSSLDSIEMA CCCCCCCCHHHHHHH	34.53	28833060
180	Phosphorylation	PGRSSLDSIEMAYAR CCCCCHHHHHHHHHE	26.24	22942356
185	Phosphorylation	LDSIEMAYARQIYIY HHHHHHHHHEEEEEE	10.87	28833060
236	Phosphorylation	QMTDVVLTPATDALK HHHCEEEECCCHHHH	10.16	26745281
239	Phosphorylation	DVVLTPATDALKSRS CEEEECCCHHHHCCC	24.02	26745281
243	Ubiquitination	TPATDALKSRSSVEV ECCCHHHHCCCCCHH	45.61	22790023
247	Ubiquitination	DALKSRSSVEVRMDF HHHHCCCCCHHHHHH	22.61	27667366
359	Ubiquitination	FQEYMNSKDRRLSPA HHHHHCCCCCCCCHH	50.69	22790023
364	Phosphorylation	NSKDRRLSPATENKL CCCCCCCCHHHHHHH	15.63	26824392
367	Phosphorylation	DRRLSPATENKLRLH CCCCCHHHHHHHHHH	43.40	22817900
370	Ubiquitination	LSPATENKLRLHYRR CCHHHHHHHHHHHHH	28.84	22790023
429	Phosphorylation	CFDDDGTSSPQDRLT EECCCCCCCHHHHHC	45.62	28066266
430	Phosphorylation	FDDDGTSSPQDRLTL ECCCCCCCHHHHHCH	26.81	28066266
438	Phosphorylation	PQDRLTLSQFQKQLL HHHHHCHHHHHHHHH	24.58	22006019
592	Phosphorylation	GKLENDGSRKPGVID EECCCCCCCCCCCCC	39.74	21454597
602	Phosphorylation	PGVIDKFTSDTKPII CCCCCCCCCCCHHHH	31.28	29472430
603	Phosphorylation	GVIDKFTSDTKPIIN CCCCCCCCCCHHHHH	46.55	29472430
605	Phosphorylation	IDKFTSDTKPIINKV CCCCCCCCHHHHHHH	38.19	29472430
606	Malonylation	DKFTSDTKPIINKVA CCCCCCCHHHHHHHH	38.93	26320211
611	Ubiquitination	DTKPIINKVASVAEN CCHHHHHHHHHHHHH	28.86	22790023
619	Ubiquitination	VASVAENKGLFEEAA HHHHHHHCCHHHHHH	48.79	22790023
627	Ubiquitination	GLFEEAAKLYDLAKN CHHHHHHHHHHHHHC	55.41	22790023
641	Ubiquitination	NADKVLELMNKLLSP CHHHHHHHHHHHHCC	3.92	27667366
644	Ubiquitination	KVLELMNKLLSPVVP HHHHHHHHHHCCCCC	36.52	22790023
764	Ubiquitination	FTQFKRLKGTSPSSA HHHHHHHCCCCCCCC	65.26	27667366
766	Phosphorylation	QFKRLKGTSPSSATR HHHHHCCCCCCCCCC	35.56	23684622
767	Phosphorylation	FKRLKGTSPSSATRP HHHHCCCCCCCCCCC	31.30	23684622
769	Phosphorylation	RLKGTSPSSATRPQR HHCCCCCCCCCCCHH	32.16	27149854
770	Phosphorylation	LKGTSPSSATRPQRV HCCCCCCCCCCCHHH	36.72	27149854
772	Phosphorylation	GTSPSSATRPQRVIE CCCCCCCCCCHHHHC	44.84	25619855
783	Phosphorylation	RVIEDRDSQLRSQAR HHHCCCHHHHHHHHH	31.82	29899451
794	Phosphorylation	SQARALITFAGMIPY HHHHHHHHHHHCCCC	14.32	22817900
801	Phosphorylation	TFAGMIPYRTSGDTN HHHHCCCCCCCCCCC	18.65	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUP93_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUP93_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUP93_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NUP93_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.