NAT10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAT10_MOUSE
• UniProt AC: Q8K224
• Protein Name: RNA cytidine acetyltransferase {ECO:0000255|HAMAP-Rule:MF_03211}
• Gene Name: Nat10 {ECO:0000255|HAMAP-Rule:MF_03211}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1024
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (Probable). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (By similarity)..
• Protein Sequence: MNRKKVDNRIRILIENGVAERQRSLFVVVGDRGKDQVVILHHMLSKATVKARPSVLWCYKKELGFSSHRKKRMRQLQKKIKSGTLNLKQDDPFELFVAATNIRYCYYNETHKILGNTFGMCVLQDFEALTPNLLARTVETVEGGGLVVILLRTMNSLKQLYTMTMDVHSRYRTEAHQDVVGRFNERFILSLASCKKCLVIDDQLDILPISSHVASIEALPPQAPDENLSPAALELLELKESLQDTQPVGVLVDCCKTLDQAKAVLKFIEGISEKTLRSTVALTAARGRGKSAALGLAIAGAVAFGYSNIFVTSPSPDNLHTLFEFVFKGFDALQYQEHLDYEIVQSLNPEFNKAVIRVNVFREHRQTIQYIHPADAVKLGQAELVVIDEAAAIPLPLVKSLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRQQSAQSQVSTTAENKTTTTARLASARTLHEVSLQESIRYAPGDAVEKWLNDLLCLDCLNITRIVSGCPLPEACELYYVNRDTLFCYHKASEVFLQRLMALYVASHYKNSPNDLQMLSDAPAHHLFCLLPPVPPTQNALPEVLAVVQVCLEGEISRQSILNSLSRGKKASGDLIPWTVSEQFQDPDFGGLSGGRVVRIAVHPDYQGMGYGSRALQLLQMYYEGKFPCLEEKVLETPQEIRTVSSEAVSLLEEVITPRKDLPPLLLKLNERPAERLDYLGVSYGLTPRLLKFWKRAGFVPVYLRQTPNDLTGEHSCIMLKTLADEDEAEQGAWLAAFWKDFRRRFLALLSYQFSTFSPALSLNIIQNRNVAKSALPALGREHLEALFLPYDLKRLEMYSRNMVDYHLIMDLIPAISRLYFLNQLGDLSLSAAQSALLLGIGLQHKSVDQLEKEIELPSGQLMGLFNRIIRKVVKLFNDVQEKAIEEQMVAVKDVVMEPTMKTLSDDLDEAAKEFQEKHKKEVGKLKDMDLSQYVIRGDDEEWNEVLSKAGQNASIVSLKSDKKRKLETKQEPKQSKKLKKRDNNRKDMKLKRKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	YKKELGFSSHRKKRM HCCCCCCCHHHHHHH	24.36	28066266
67	Phosphorylation	KKELGFSSHRKKRMR CCCCCCCHHHHHHHH	25.67	28066266
416	Phosphorylation	MASTINGYEGTGRSL EEECCCCCCCCCHHH	13.49	30804169
426	Malonylation	TGRSLSLKLIQQLRQ CCHHHHHHHHHHHHH	39.92	26073543
426	Acetylation	TGRSLSLKLIQQLRQ CCHHHHHHHHHHHHH	39.92	23236377
435	Phosphorylation	IQQLRQQSAQSQVST HHHHHHHHHHHHCCC	21.67	23140645
471	Phosphorylation	SLQESIRYAPGDAVE CHHHHHCCCCCCHHH	18.58	27180971
586	Phosphorylation	VCLEGEISRQSILNS HHHCCCCHHHHHHHH	21.69	51459625
666	Phosphorylation	LEEKVLETPQEIRTV HHHHHCCCHHHHHHC	26.55	26824392
672	Phosphorylation	ETPQEIRTVSSEAVS CCHHHHHHCCHHHHH	30.33	26745281
674	Phosphorylation	PQEIRTVSSEAVSLL HHHHHHCCHHHHHHH	23.11	26745281
675	Phosphorylation	QEIRTVSSEAVSLLE HHHHHCCHHHHHHHH	25.82	26745281
679	Phosphorylation	TVSSEAVSLLEEVIT HCCHHHHHHHHHHCC	33.99	26745281
686	Phosphorylation	SLLEEVITPRKDLPP HHHHHHCCCCCCCCC	23.40	22006019
716	Phosphorylation	LGVSYGLTPRLLKFW CCCCCCCCHHHHHHH	11.29	-
932	Phosphorylation	VMEPTMKTLSDDLDE HCCCCCHHCCHHHHH	22.22	25619855
934	Phosphorylation	EPTMKTLSDDLDEAA CCCCHHCCHHHHHHH	34.02	25521595
961	Phosphorylation	KLKDMDLSQYVIRGD CCCCCCHHHHEECCC	18.39	30815139
984	Phosphorylation	SKAGQNASIVSLKSD HHHCCCCEEEEECCH	30.95	28066266
987	Phosphorylation	GQNASIVSLKSDKKR CCCCEEEEECCHHHC	28.54	28066266
990	Phosphorylation	ASIVSLKSDKKRKLE CEEEEECCHHHCCCC	61.01	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAT10_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAT10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAT10_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NAT10_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.