GRAB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRAB_MOUSE
• UniProt AC: P04187
• Protein Name: Granzyme B(G,H)
• Gene Name: Gzmb
• Organism: Mus musculus (Mouse).
• Sequence Length: 247
• Subcellular Localization: Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
• Protein Description: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity)..
• Protein Sequence: MKILLLLLTLSLASRTKAGEIIGGHEVKPHSRPYMALLSIKDQQPEAICGGFLIREDFVLTAAHCEGSIINVTLGAHNIKEQEKTQQVIPMVKCIPHPDYNPKTFSNDIMLLKLKSKAKRTRAVRPLNLPRRNVNVKPGDVCYVAGWGRMAPMGKYSNTLQEVELTVQKDRECESYFKNRYNKTNQICAGDPKTKRASFRGDSGGPLVCKKVAAGIVSYGYKDGSPPRAFTKVSSFLSWIKKTMKSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	N-linked_Glycosylation	HCEGSIINVTLGAHN HHCCEEEEEEECCCC	21.03	-
104	Phosphorylation	HPDYNPKTFSNDIML CCCCCCCCCCCCEEH	33.29	27087446
106	Phosphorylation	DYNPKTFSNDIMLLK CCCCCCCCCCEEHHH	38.53	27087446
121	Phosphorylation	LKSKAKRTRAVRPLN CHHHCCCCCCCCCCC	23.44	21454597
156	Phosphorylation	RMAPMGKYSNTLQEV CCCCCCCCCCCCEEE	11.04	28576409
159	Phosphorylation	PMGKYSNTLQEVELT CCCCCCCCCEEEEEE	24.71	28576409
166	Phosphorylation	TLQEVELTVQKDREC CCEEEEEEECCHHHH	13.84	28576409
182	N-linked_Glycosylation	SYFKNRYNKTNQICA HHHHHCCCCCCCEEC	41.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRAB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRAB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRAB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CASP3_MOUSE	Casp3	physical	17283187
CASP7_MOUSE	Casp7	physical	17283187
CASP3_HUMAN	CASP3	physical	17283187
CASP7_HUMAN	CASP7	physical	17283187
CD2AP_HUMAN	CD2AP	physical	17283187

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.