CASP7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASP7_MOUSE
• UniProt AC: P97864
• Protein Name: Caspase-7
• Gene Name: Casp7
• Organism: Mus musculus (Mouse).
• Sequence Length: 303
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Overexpression promotes programmed cell death (By similarity)..
• Protein Sequence: MTDDQDCAAELEKVDSSSEDGVDAKPDRSSIISSILLKKKRNASAGPVRTGRDRVPTYLYRMDFQKMGKCIIINNKNFDKATGMDVRNGTDKDAGALFKCFQNLGFEVTVHNDCSCAKMQDLLRKASEEDHSNSACFACVLLSHGEEDLIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDIDANPRNKIPVEADFLFAYSTVPGYYSWRNPGKGSWFVQALCSILNEHGKDLEIMQILTRVNDRVARHFESQSDDPRFNEKKQIPCMVSMLTKELYFSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTDDQDCA -------CCCHHHHH	9.28	17242355
2	Phosphorylation	------MTDDQDCAA ------CCCHHHHHH	48.56	25619855
16	Phosphorylation	AELEKVDSSSEDGVD HHHHHCCCCCCCCCC	38.46	25521595
17	Phosphorylation	ELEKVDSSSEDGVDA HHHHCCCCCCCCCCC	33.03	25521595
18	Phosphorylation	LEKVDSSSEDGVDAK HHHCCCCCCCCCCCC	43.59	25521595
29	Phosphorylation	VDAKPDRSSIISSIL CCCCCCHHHHHHHHH	33.01	22324799
30	Phosphorylation	DAKPDRSSIISSILL CCCCCHHHHHHHHHH	25.49	22324799
33	Phosphorylation	PDRSSIISSILLKKK CCHHHHHHHHHHHHH	15.06	22324799
34	Phosphorylation	DRSSIISSILLKKKR CHHHHHHHHHHHHHC	13.57	29514104
44	Phosphorylation	LKKKRNASAGPVRTG HHHHCCCCCCCCCCC	36.99	30635358
80	Ubiquitination	INNKNFDKATGMDVR ECCCCCCCCCCCCCC	43.65	22790023
199	Phosphorylation	DDGIQADSGPINDID CCCCCCCCCCCCCCC	49.86	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CASP7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CASP7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASP7_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XIAP_MOUSE	Xiap	physical	11859414
PSME3_MOUSE	Psme3	physical	11859414
TEBP_MOUSE	Ptges3	physical	18723680
ROCK1_MOUSE	Rock1	physical	18723680
GDIR1_MOUSE	Arhgdia	physical	18723680

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.
PubMed: 19367708