GDIR1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDIR1_MOUSE
• UniProt AC: Q99PT1
• Protein Name: Rho GDP-dissociation inhibitor 1
• Gene Name: Arhgdia
• Organism: Mus musculus (Mouse).
• Sequence Length: 204
• Subcellular Localization: Cytoplasm .
• Protein Description: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1..
• Protein Sequence: MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVAVSADPNVPNVIVTRLTLVCSTAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKIDKTDYMVGSYGPRAEEYEFLTPMEEAPKGMLARGSYNIKSRFTDDDKTDHLSWEWNLTIKKEWKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEQEPTAE ------CCCCCCCHH	27.46	-
7	Phosphorylation	-MAEQEPTAEQLAQI -CCCCCCCHHHHHHH	41.91	25619855
24	Phosphorylation	ENEEDEHSVNYKPPA HCCCCCCCCCCCCCC	15.26	26824392
27	Phosphorylation	EDEHSVNYKPPAQKS CCCCCCCCCCCCHHH	23.79	25619855
28	Acetylation	DEHSVNYKPPAQKSI CCCCCCCCCCCHHHH	39.04	23236377
34	Phosphorylation	YKPPAQKSIQEIQEL CCCCCHHHHHHHHHH	19.88	25521595
43	Acetylation	QEIQELDKDDESLRK HHHHHHCCCCHHHHH	78.63	23806337
43	Ubiquitination	QEIQELDKDDESLRK HHHHHHCCCCHHHHH	78.63	22790023
47	Phosphorylation	ELDKDDESLRKYKEA HHCCCCHHHHHHHHH	40.23	26824392
51	Phosphorylation	DDESLRKYKEALLGR CCHHHHHHHHHHHHC	13.97	29514104
52	Acetylation	DESLRKYKEALLGRV CHHHHHHHHHHHHCE	39.28	23806337
52	Succinylation	DESLRKYKEALLGRV CHHHHHHHHHHHHCE	39.28	23806337
52	Malonylation	DESLRKYKEALLGRV CHHHHHHHHHHHHCE	39.28	26320211
62	Phosphorylation	LLGRVAVSADPNVPN HHHCEECCCCCCCCC	19.74	27180971
79	Glutathionylation	VTRLTLVCSTAPGPL EEEEEEEEECCCCCE	3.17	24333276
96	Phosphorylation	DLTGDLESFKKQSFV ECCCCHHHHHHEEEE	50.06	19581409
98	Acetylation	TGDLESFKKQSFVLK CCCHHHHHHEEEEEE	60.21	156627
99	Malonylation	GDLESFKKQSFVLKE CCHHHHHHEEEEEEC	49.52	26320211
99	Acetylation	GDLESFKKQSFVLKE CCHHHHHHEEEEEEC	49.52	22826441
99	Ubiquitination	GDLESFKKQSFVLKE CCHHHHHHEEEEEEC	49.52	27667366
101	Phosphorylation	LESFKKQSFVLKEGV HHHHHHEEEEEECCE	26.63	26824392
105	Acetylation	KKQSFVLKEGVEYRI HHEEEEEECCEEEEE	47.31	22826441
105	Succinylation	KKQSFVLKEGVEYRI HHEEEEEECCEEEEE	47.31	23954790
127	Malonylation	REIVSGMKYIQHTYR HHHHCCCCHHHHHHC	42.60	26320211
127	Ubiquitination	REIVSGMKYIQHTYR HHHHCCCCHHHHHHC	42.60	-
127	Acetylation	REIVSGMKYIQHTYR HHHHCCCCHHHHHHC	42.60	23236377
132	Phosphorylation	GMKYIQHTYRKGVKI CCCHHHHHHCCCCCC	14.51	29472430
133	Phosphorylation	MKYIQHTYRKGVKID CCHHHHHHCCCCCCC	14.27	29472430
138	Malonylation	HTYRKGVKIDKTDYM HHHCCCCCCCCCCCC	54.58	26320211
138	Ubiquitination	HTYRKGVKIDKTDYM HHHCCCCCCCCCCCC	54.58	-
141	Ubiquitination	RKGVKIDKTDYMVGS CCCCCCCCCCCCCCC	46.93	27667366
141	Succinylation	RKGVKIDKTDYMVGS CCCCCCCCCCCCCCC	46.93	23806337
141	Succinylation	RKGVKIDKTDYMVGS CCCCCCCCCCCCCCC	46.93	-
141	Acetylation	RKGVKIDKTDYMVGS CCCCCCCCCCCCCCC	46.93	23806337
141	Malonylation	RKGVKIDKTDYMVGS CCCCCCCCCCCCCCC	46.93	26320211
148	Phosphorylation	KTDYMVGSYGPRAEE CCCCCCCCCCCCHHH	18.59	24899341
149	Phosphorylation	TDYMVGSYGPRAEEY CCCCCCCCCCCHHHE	25.81	29472430
160	Phosphorylation	AEEYEFLTPMEEAPK HHHEEEECCHHHCCC	26.38	-
167	Acetylation	TPMEEAPKGMLARGS CCHHHCCCCCCCCCC	65.09	23236377
167	Ubiquitination	TPMEEAPKGMLARGS CCHHHCCCCCCCCCC	65.09	22790023
174	Phosphorylation	KGMLARGSYNIKSRF CCCCCCCCEECCCCC	14.95	24719451
178	Succinylation	ARGSYNIKSRFTDDD CCCCEECCCCCCCCC	31.76	23954790
178	Ubiquitination	ARGSYNIKSRFTDDD CCCCEECCCCCCCCC	31.76	27667366
178	Malonylation	ARGSYNIKSRFTDDD CCCCEECCCCCCCCC	31.76	26320211
178	Acetylation	ARGSYNIKSRFTDDD CCCCEECCCCCCCCC	31.76	23806337
179	Phosphorylation	RGSYNIKSRFTDDDK CCCEECCCCCCCCCC	28.91	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
96	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDIR1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDIR1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GDIR1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.