dbPTM

RFC4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RFC4_MOUSE
UniProt AC	Q99J62
Protein Name	Replication factor C subunit 4
Gene Name	Rfc4
Organism	Mus musculus (Mouse).
Sequence Length	364
Subcellular Localization	Nucleus .
Protein Description	The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity)..
Protein Sequence	MQAFLKGTSVSAKAQLTKDRGTPATAGSSGETKKVKPVPWVEKYRPKCVDEVAFQDEVVAVLRKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQERLLDIAEKENVKIGNEEIAYLVKISEGDLRKAITFLQSATRLTGGKEVSEDVITDIAGVIPAATIDGIFTACHSGSFDKLEAVVKNLIDEGHAATQLVNQLHDAIIENENLSDKHKSIITEKLAEVDKCLADGADEHLQLMSLCATVMQQLTQNC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MQAFLKGT -------CCCCCCCC	6.14	-
6	Acetylation	--MQAFLKGTSVSAK --CCCCCCCCCEEHE	54.40	-
13	Acetylation	KGTSVSAKAQLTKDR CCCCEEHEEECCCCC	29.20	6585159
22	Phosphorylation	QLTKDRGTPATAGSS ECCCCCCCCCCCCCC	15.62	29550500
28	Phosphorylation	GTPATAGSSGETKKV CCCCCCCCCCCCCCC	32.48	29550500
29	O-linked_Glycosylation	TPATAGSSGETKKVK CCCCCCCCCCCCCCC	39.47	30059200
29	Phosphorylation	TPATAGSSGETKKVK CCCCCCCCCCCCCCC	39.47	26824392
32	Phosphorylation	TAGSSGETKKVKPVP CCCCCCCCCCCCCCC	39.42	29550500
135	Methylation	QLTVSGSRSDGKPCP EEEECCCCCCCCCCC	42.14	16187681

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RFC4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RFC4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RFC4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RFC4_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RFC4_MOUSE

Related Literatures of Post-Translational Modification