RL27_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL27_MOUSE
• UniProt AC: P61358
• Protein Name: 60S ribosomal protein L27
• Gene Name: Rpl27
• Organism: Mus musculus (Mouse).
• Sequence Length: 136
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm . Rough endoplasmic reticulum . Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
• Protein Description: Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity)..
• Protein Sequence: MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MGKFMKPGKV -----CCCCCCCCEE	40.77	23864654
6	Acetylation	--MGKFMKPGKVVLV --CCCCCCCCEEEEE	54.47	2373155
9	Malonylation	GKFMKPGKVVLVLAG CCCCCCCEEEEEEEE	37.38	26073543
9	Acetylation	GKFMKPGKVVLVLAG CCCCCCCEEEEEEEE	37.38	23201123
27	Acetylation	GRKAVIVKNIDDGTS CCEEEEEEECCCCCC	36.74	23576753
27	Ubiquitination	GRKAVIVKNIDDGTS CCEEEEEEECCCCCC	36.74	-
27	Malonylation	GRKAVIVKNIDDGTS CCEEEEEEECCCCCC	36.74	26320211
33	Phosphorylation	VKNIDDGTSDRPYSH EEECCCCCCCCCCCE	34.15	25521595
34	Phosphorylation	KNIDDGTSDRPYSHA EECCCCCCCCCCCEE	36.83	25367039
38	Phosphorylation	DGTSDRPYSHALVAG CCCCCCCCCEEEECC	17.62	25367039
39	Phosphorylation	GTSDRPYSHALVAGI CCCCCCCCEEEECCH	12.64	25367039
49	Phosphorylation	LVAGIDRYPRKVTAA EECCHHCCCHHHHHH	12.02	25367039
59	Acetylation	KVTAAMGKKKIAKRS HHHHHHCCHHHHHHH	37.50	23201123
73	Ubiquitination	SKIKSFVKVYNYNHL HHCHHEEEECCCCCC	36.67	22790023
73	Acetylation	SKIKSFVKVYNYNHL HHCHHEEEECCCCCC	36.67	22826441
77	Phosphorylation	SFVKVYNYNHLMPTR HEEEECCCCCCCCCE	6.05	26643407
83	Phosphorylation	NYNHLMPTRYSVDIP CCCCCCCCEEEEECC	28.42	26643407
85	Phosphorylation	NHLMPTRYSVDIPLD CCCCCCEEEEECCCC	18.61	26643407
86	Phosphorylation	HLMPTRYSVDIPLDK CCCCCEEEEECCCCC	15.26	27180971
93	Ubiquitination	SVDIPLDKTVVNKDV EEECCCCCCCCCCHH	51.40	-
93	Malonylation	SVDIPLDKTVVNKDV EEECCCCCCCCCCHH	51.40	26320211
93	Acetylation	SVDIPLDKTVVNKDV EEECCCCCCCCCCHH	51.40	23864654
98	Acetylation	LDKTVVNKDVFRDPA CCCCCCCCHHHCCHH	43.59	23864654
98	Malonylation	LDKTVVNKDVFRDPA CCCCCCCCHHHCCHH	43.59	26320211
98	Ubiquitination	LDKTVVNKDVFRDPA CCCCCCCCHHHCCHH	43.59	-
107	Ubiquitination	VFRDPALKRKARREA HHCCHHHHHHHHHHH	54.69	22790023
107	Acetylation	VFRDPALKRKARREA HHCCHHHHHHHHHHH	54.69	23864654
117	Acetylation	ARREAKVKFEERYKT HHHHHCCCHHHHHCC	46.48	23864654
128	Acetylation	RYKTGKNKWFFQKLR HHCCCCCCCCEECCC	49.19	23201123
128	Malonylation	RYKTGKNKWFFQKLR HHCCCCCCCCEECCC	49.19	26320211
128	Ubiquitination	RYKTGKNKWFFQKLR HHCCCCCCCCEECCC	49.19	-
133	Ubiquitination	KNKWFFQKLRF---- CCCCCEECCCC----	36.15	22790023
133	Acetylation	KNKWFFQKLRF---- CCCCCEECCCC----	36.15	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL27_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL27_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL27_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RL27_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.