DDX18_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX18_MOUSE
• UniProt AC: Q8K363
• Protein Name: ATP-dependent RNA helicase DDX18
• Gene Name: Ddx18
• Organism: Mus musculus (Mouse).
• Sequence Length: 660
• Subcellular Localization: Nucleus, nucleolus . Chromosome .
• Protein Description: Probable RNA-dependent helicase..
• Protein Sequence: MSQLQMKLLRRKIEKRNAKLRQRNLKLQETSDTSLSQPQNGDVPKETGKGGKVKKALKRSVPVDSAEAQSGGMPEETLENGKVKKSPQKLTTLANGEAAPTPPPDSEVKKKKKKKRKMANDAGPDTKKAKTEESAEACEEPEDDVKKADDSEVPSLPLGLTGAFEDTSFASLSNLVNENTLKAIEEMGFKRMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPVIELIVKLKFMPRNGTGVLILSPTRELAMQTFGVLKELMTHHVHTYGLIMGGSNRSAEVQKLLNGINIIVATPGRLLDHMQNTPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPARRQTMLFSATQTRKVEDLARISLKKEPLYVGVDDDKEVATVDGLEQGYVVCPSEKRFLLLFTFLKKNRKKKVMVFFSSCMSVKYHYELLNYIDLPVLAIHGKQKQNKRTTTFFQFCNADSGILLCTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGLNGRGHALLILRPEELGFLRYLKQSKVPLNQFDFSWSKVSDIQSQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALSFGFKVPPFVDLNVSSHDGKLKKRGGGGGFGYQKTKKVEKSKIFKHISKKPADRRQFSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	RNLKLQETSDTSLSQ HHHCCCCCCCCCCCC	20.95	22006019
86	Phosphorylation	ENGKVKKSPQKLTTL HCCCCCCCCCHHEEC	27.18	21659605
91	Phosphorylation	KKSPQKLTTLANGEA CCCCCHHEECCCCCC	27.14	23984901
92	Phosphorylation	KSPQKLTTLANGEAA CCCCHHEECCCCCCC	34.02	23984901
101	Phosphorylation	ANGEAAPTPPPDSEV CCCCCCCCCCCCHHH	43.64	22942356
106	Phosphorylation	APTPPPDSEVKKKKK CCCCCCCHHHHHHHH	50.49	25619855
131	Phosphorylation	PDTKKAKTEESAEAC CCCHHHCCHHHHHHH	50.25	25159016
134	Phosphorylation	KKAKTEESAEACEEP HHHCCHHHHHHHCCC	25.77	25159016
448	Acetylation	PVLAIHGKQKQNKRT CEEEEECCCCCCCCC	39.91	23236377
544	Phosphorylation	PLNQFDFSWSKVSDI CHHHCCCCHHHHHHH	32.08	22006019
616	Phosphorylation	PFVDLNVSSHDGKLK CEEEEEECCCCCCCC	22.38	28066266
617	Phosphorylation	FVDLNVSSHDGKLKK EEEEEECCCCCCCCC	22.70	28066266
633	Phosphorylation	GGGGGFGYQKTKKVE CCCCCCCCCCCCCCH	12.46	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
101	T	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX18_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX18_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DDX18_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.