SMRD2_MOUSE - dbPTM
SMRD2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SMRD2_MOUSE
UniProt AC Q99JR8
Protein Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
Gene Name Smarcd2
Organism Mus musculus (Mouse).
Sequence Length 531
Subcellular Localization Nucleus .
Protein Description Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation..
Protein Sequence MSGRGAGGFPLPPLSPGGGAVAAALGAPPPPAGPGMLPSPALRGPGPSGGMGVPGAAAFRPMGPAGPAAQYQRPGMSPGSRMPMAGLQVGPPAGSPFGTAAPLRPGMPPTMMDPFRKRLLVPQAQPPMPAQRRGLKRRKMADKVLPQRIRELVPESQAYMDLLAFERKLDQTIARKRMEIQEAIKKPLTQKRKLRIYISNTFSPSKADGDNAGTAGTPGGTPAADKVASWELRVEGKLLDDPSKQKRKFSSFFKSLVIELDKELYGPDNHLVEWHRMPTTQETDGFQVKRPGDLNVKCTLLLMLDHQPPQYKLDPRLARLLGVHTQTRAAIMQALWLYIKHNQLQDGHEREYINCNRYFRQIFSCGRLRFSEIPMKLAGLLQHPDPIVINHVISVDPNDQKKTACYDIDVEVDDPLKAQMSNFLASTTNQQEIASLDVKIHETIESINQLKTQRDFMLSFSTEPQDFIQEWLRSQRRDLKIITDVIGNPEEERRAAFYHQPWAQEAVGRHIFAKVQQRRQELEQVLGIRLT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSGRGAGGF
------CCCCCCCCC		36.8825777480
15PhosphorylationGFPLPPLSPGGGAVA
CCCCCCCCCCCCHHH		27.5424719451
39PhosphorylationAGPGMLPSPALRGPG
CCCCCCCCHHHCCCC		20.8825777480
81Asymmetric dimethylargininePGMSPGSRMPMAGLQ
CCCCCCCCCCCCCCE		38.86-
81MethylationPGMSPGSRMPMAGLQ
CCCCCCCCCCCCCCE		38.86-
104MethylationFGTAAPLRPGMPPTM
CCCCCCCCCCCCCCC		25.35-
104Asymmetric dimethylarginineFGTAAPLRPGMPPTM
CCCCCCCCCCCCCCC		25.35-
185AcetylationMEIQEAIKKPLTQKR
HHHHHHHHCCCCCCC		56.2215608251
197PhosphorylationQKRKLRIYISNTFSP
CCCCEEEEEECCCCC		7.5825619855
199PhosphorylationRKLRIYISNTFSPSK
CCEEEEEECCCCCCC		16.9125619855
201PhosphorylationLRIYISNTFSPSKAD
EEEEEECCCCCCCCC		20.7825619855
203PhosphorylationIYISNTFSPSKADGD
EEEECCCCCCCCCCC		26.6526824392
205PhosphorylationISNTFSPSKADGDNA
EECCCCCCCCCCCCC		39.0025619855
214PhosphorylationADGDNAGTAGTPGGT
CCCCCCCCCCCCCCC		21.3625619855
217PhosphorylationDNAGTAGTPGGTPAA
CCCCCCCCCCCCCCH		19.1225521595
221PhosphorylationTAGTPGGTPAADKVA
CCCCCCCCCCHHHHC		18.7025619855
244UbiquitinationKLLDDPSKQKRKFSS
EECCCHHHHHHHHHH		66.29-
262UbiquitinationSLVIELDKELYGPDN
HHHHHHHHHHHCCCC		63.34-
289UbiquitinationETDGFQVKRPGDLNV
CCCCCEECCCCCCCC		41.93-
325PhosphorylationARLLGVHTQTRAAIM
HHHHCCCHHHHHHHH		29.2728066266
327PhosphorylationLLGVHTQTRAAIMQA
HHCCCHHHHHHHHHH		24.3528066266
352PhosphorylationQDGHEREYINCNRYF
CCCCCCCCCCHHHHH		12.03-
451UbiquitinationIESINQLKTQRDFML
HHHHHHHHHCHHHHH		32.61-
459PhosphorylationTQRDFMLSFSTEPQD
HCHHHHHHCCCCHHH		12.8321454597
461PhosphorylationRDFMLSFSTEPQDFI
HHHHHHCCCCHHHHH		28.6021454597
462PhosphorylationDFMLSFSTEPQDFIQ
HHHHHCCCCHHHHHH		50.0721454597
480UbiquitinationRSQRRDLKIITDVIG
HHCCCCCCHHHHCCC		36.03-
514UbiquitinationVGRHIFAKVQQRRQE
HHHHHHHHHHHHHHH		29.81-
531PhosphorylationQVLGIRLT-------
HHHCCCCC-------		27.0727600695
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SMRD2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SMRD2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SMRD2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SMRD2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SMRD2_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory