HNRL2_MOUSE - dbPTM
HNRL2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HNRL2_MOUSE
UniProt AC Q00PI9
Protein Name Heterogeneous nuclear ribonucleoprotein U-like protein 2
Gene Name Hnrnpul2
Organism Mus musculus (Mouse).
Sequence Length 745
Subcellular Localization Nucleus .
Protein Description
Protein Sequence MEVKRLKVTELRSELQRRGLDSRGLKMDLAQRLQEALDAEMLEDEAGVGGAGPGGACKAEPRPVAASGGGPGGDEEEEDDDEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPETSAMEAESEASDTPAEATAGSGGVNGGEEHDNGKGEEDGPEERSGDETPGSEAPGDKAVEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPPPPEEEAKDEEEDQTLVNLDTYTSDLHFQISKDRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQNLPMKEGCTEVSLLRVGWSVDFSCSQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDVIGCFANFETEEVELSFSKNGEDLGVAFRISKESLADRALLPHVLCKNCVVELNFGQKEEPFFPPPEEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKDNPERRYNVLGAETVLTQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRSKRNFILDQCNVYNSGQRRKLLLFKTFSRKVVVVVPNEEDWKRRLELRKEVEGDDVPESIMLEMKANFSLPEKCDYMDEVTYGELEKEEAQPIVTKYKEEARKLLPPSEKRTNRRNNRNKRNRQNRSRGQGYVGGQRRGYDNRAYGQQYWGQSGNRGGYRNFYDRYRGDYERFYSRDYEYNRYRDYYRQYNRDWQNYYYHHQQDRDRYYRNYYGYQGYR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26AcetylationGLDSRGLKMDLAQRL
CCCHHCCCCHHHHHH		32.9422826441
159PhosphorylationEDGPEERSGDETPGS
CCCCCCCCCCCCCCC		54.6027087446
163PhosphorylationEERSGDETPGSEAPG
CCCCCCCCCCCCCCC		37.3825521595
166PhosphorylationSGDETPGSEAPGDKA
CCCCCCCCCCCCCHH		31.6125521595
183PhosphorylationEQGDDQDSEKSKPAG
HCCCCCCCCCCCCCC		41.0925521595
185UbiquitinationGDDQDSEKSKPAGSD
CCCCCCCCCCCCCCH		68.6727667366
186PhosphorylationDDQDSEKSKPAGSDG
CCCCCCCCCCCCCHH		39.5627087446
191PhosphorylationEKSKPAGSDGERRGV
CCCCCCCCHHHCCCC		44.5427087446
212PhosphorylationKDEHGRAYYEFREEA
CCHHHCHHHHHHHHH		11.3623375375
222PhosphorylationFREEAYHSRSKSPPP
HHHHHHHCCCCCCCC		26.1023375375
224PhosphorylationEEAYHSRSKSPPPPE
HHHHHCCCCCCCCCH		40.2625521595
226PhosphorylationAYHSRSKSPPPPEEE
HHHCCCCCCCCCHHH		43.8327087446
242PhosphorylationKDEEEDQTLVNLDTY
CCHHHHCEEEEHHHH		45.0223335269
248PhosphorylationQTLVNLDTYTSDLHF
CEEEEHHHHCCCEEE		31.6825159016
249PhosphorylationTLVNLDTYTSDLHFQ
EEEEHHHHCCCEEEE		12.1525159016
250PhosphorylationLVNLDTYTSDLHFQI
EEEHHHHCCCEEEEE		20.1825159016
251PhosphorylationVNLDTYTSDLHFQIS
EEHHHHCCCEEEEEE		27.9725159016
258PhosphorylationSDLHFQISKDRYGGQ
CCEEEEEECCCCCCC		20.0925159016
261MethylationHFQISKDRYGGQPLF
EEEEECCCCCCCCCC		35.4130987679
269PhosphorylationYGGQPLFSEKFPTLW
CCCCCCCCCCCCCCC		47.7826824392
271UbiquitinationGQPLFSEKFPTLWSG
CCCCCCCCCCCCCCC		56.2822790023
271UbiquitinationGQPLFSEKFPTLWSG
CCCCCCCCCCCCCCC		56.2822790023
287UbiquitinationRSTYGVTKGKVCFEA
CCCCCCCCCEEEEEE		55.0927667366
303AcetylationVTQNLPMKEGCTEVS
ECCCCCCCCCCEEEE		49.3622826441
306S-palmitoylationNLPMKEGCTEVSLLR
CCCCCCCCEEEEEEE		2.8428526873
388PhosphorylationLGVAFRISKESLADR
CEEEEEECHHHHHHH		26.56-
440PhosphorylationPVEERVRTAVPPKTI
EHHHHHHCCCCCCCH		29.2018779572
469UbiquitinationGKTQWALKYAKDNPE
CHHHHHHHHHCCCHH		35.1022790023
469UbiquitinationGKTQWALKYAKDNPE
CHHHHHHHHHCCCHH		35.1022790023
479PhosphorylationKDNPERRYNVLGAET
CCCHHHCHHHCCHHH		18.8224759943
486PhosphorylationYNVLGAETVLTQMRM
HHHCCHHHHHHHHHH		21.9321659604
489PhosphorylationLGAETVLTQMRMKGL
CCHHHHHHHHHHCCC		18.9124759943
504UbiquitinationEEPEMDPKSRDLLVQ
CCCCCCHHHHHHHHH		54.5927667366
519UbiquitinationQASQCLSKLVQIASR
HHHHHHHHHHHHHHH		39.46-
541PhosphorylationDQCNVYNSGQRRKLL
CCCCCCCCCCCEEEE		20.72-
551UbiquitinationRRKLLLFKTFSRKVV
CEEEEEEEECCCEEE		48.9422790023
551UbiquitinationRRKLLLFKTFSRKVV
CEEEEEEEECCCEEE		48.9422790023
568UbiquitinationVPNEEDWKRRLELRK
CCCHHHHHHHHHHHH		39.7122790023
568UbiquitinationVPNEEDWKRRLELRK
CCCHHHHHHHHHHHH		39.7122790023
599UbiquitinationANFSLPEKCDYMDEV
HCCCCCCCCCCCCCC		30.3922790023
599UbiquitinationANFSLPEKCDYMDEV
HCCCCCCCCCCCCCC		30.3922790023
622UbiquitinationEAQPIVTKYKEEARK
HCCCCHHHHHHHHHH		43.3522790023
622UbiquitinationEAQPIVTKYKEEARK
HCCCCHHHHHHHHHH		43.3522790023
634PhosphorylationARKLLPPSEKRTNRR
HHHHCCCCHHHHCHH		54.53-
636UbiquitinationKLLPPSEKRTNRRNN
HHCCCCHHHHCHHCC		69.7122790023
636UbiquitinationKLLPPSEKRTNRRNN
HHCCCCHHHHCHHCC		69.7122790023
653PhosphorylationKRNRQNRSRGQGYVG
HHHHHHHHCCCCCCC		48.6025521595
654DimethylationRNRQNRSRGQGYVGG
HHHHHHHCCCCCCCC		37.91-
654MethylationRNRQNRSRGQGYVGG
HHHHHHHCCCCCCCC		37.9124129315
669MethylationQRRGYDNRAYGQQYW
CCCCCCCCCHHCCCC		26.7054556763
682DimethylationYWGQSGNRGGYRNFY
CCCCCCCCCCCCCHH		43.36-
682MethylationYWGQSGNRGGYRNFY
CCCCCCCCCCCCCHH		43.3624129315
686DimethylationSGNRGGYRNFYDRYR
CCCCCCCCCHHHHHC		30.01-
686MethylationSGNRGGYRNFYDRYR
CCCCCCCCCHHHHHC		30.0112019371
693MethylationRNFYDRYRGDYERFY
CCHHHHHCCCHHHHH		32.1916186091
701PhosphorylationGDYERFYSRDYEYNR
CCHHHHHCCCCCHHH		18.9025367039
704PhosphorylationERFYSRDYEYNRYRD
HHHHCCCCCHHHHHH		21.1425367039
718MethylationDYYRQYNRDWQNYYY
HHHHHHCCCHHHHHH		41.4354556771
736MethylationQDRDRYYRNYYGYQG
HHHHHHHHHHCCCCC		18.7524129315
741PhosphorylationYYRNYYGYQGYR---
HHHHHCCCCCCC---		5.22-
745MethylationYYGYQGYR-------
HCCCCCCC-------		47.0624129315
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HNRL2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HNRL2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HNRL2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HNRL2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HNRL2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159 AND SER-186, ANDMASS SPECTROMETRY.

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