dbPTM

NCOA5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NCOA5_MOUSE
UniProt AC	Q91W39
Protein Name	Nuclear receptor coactivator 5
Gene Name	Ncoa5
Organism	Mus musculus (Mouse).
Sequence Length	579
Subcellular Localization	Nucleus.
Protein Description	Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2) (By similarity)..
Protein Sequence	MNTAPSRPSPTRRDPYSFGDSRDTRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRDLRDRRDSRDIRDHRDSRSVREARDLRDFRDFRDLRDSRDFRDHRDPVYDRYRDIRDSRDPLYRREGSYDRYLRVDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREELYRRYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNDCREKEREEIARQAAKMANDAILQERDRGGPEEGGRGGHPPAIQSLINLLADNRYLTAEETDKIINYLRERKERLLRSSADSLPGPISRQPLGAASGSSLKSQPSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLFNSGAVAANSSSASPSVATGSSQNQNFSTAANSQPQQRPQASGNQPPNIVGQAGSARNMGPRPGAPSQGLFGQPSSRLAPASTMASQRPVSSTGINFDNPSVQKALDTLIQSGPALSHLVSQTAAQVGRPQAPMGSYQRHY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNTAPSRP -------CCCCCCCC	10.17	-
3	Phosphorylation	-----MNTAPSRPSP -----CCCCCCCCCC	38.35	23527152
6	Phosphorylation	--MNTAPSRPSPTRR --CCCCCCCCCCCCC	55.12	27742792
9	Phosphorylation	NTAPSRPSPTRRDPY CCCCCCCCCCCCCCC	37.48	23527152
11	Phosphorylation	APSRPSPTRRDPYSF CCCCCCCCCCCCCCC	42.55	27742792
16	Phosphorylation	SPTRRDPYSFGDSRD CCCCCCCCCCCCCCC	22.41	21743459
17	Phosphorylation	PTRRDPYSFGDSRDT CCCCCCCCCCCCCCC	28.30	21743459
21	Phosphorylation	DPYSFGDSRDTRRDR CCCCCCCCCCCCCCC	32.22	21743459
29	Phosphorylation	RDTRRDRSPIRGSPR CCCCCCCCCCCCCCC	29.03	25521595
34	Phosphorylation	DRSPIRGSPRREPRD CCCCCCCCCCCCCCC	12.84	25521595
51	Phosphorylation	NGRDARDSRDIRDPR CCCCCCCCCCCCCHH	26.71	23684622
66	Phosphorylation	DLRDRRDSRDIRDHR HHHHCCHHCHHHHHH	30.00	23684622
75	Phosphorylation	DIRDHRDSRSVREAR HHHHHHHHHHHHHHH	26.81	29899451
88	Methylation	ARDLRDFRDFRDLRD HHHHHCHHCHHHHHC	46.58	30988625
96	Phosphorylation	DFRDLRDSRDFRDHR CHHHHHCCCCCHHCC	27.58	25266776
97	Methylation	FRDLRDSRDFRDHRD HHHHHCCCCCHHCCC	51.91	30988631
107	Phosphorylation	RDHRDPVYDRYRDIR HHCCCHHHHHHHHHH	10.49	25159016
116	Phosphorylation	RYRDIRDSRDPLYRR HHHHHHHCCCCCCCC	28.83	25159016
126	Phosphorylation	PLYRREGSYDRYLRV CCCCCCCCCCCEECH	21.07	23684622
127	Phosphorylation	LYRREGSYDRYLRVD CCCCCCCCCCEECHH	18.46	22324799
143	Phosphorylation	YCRRKDDSYFDRYRD HHHCCCCCHHHHCCC	37.52	-
148	Phosphorylation	DDSYFDRYRDSFDGR CCCHHHHCCCCCCCC	22.18	28066266
151	Phosphorylation	YFDRYRDSFDGRGPP HHHHCCCCCCCCCCC	19.08	28066266
162	Phosphorylation	RGPPGPESQSRAKER CCCCCHHHHHHHHHH	36.27	21659604
164	Phosphorylation	PPGPESQSRAKERLK CCCHHHHHHHHHHHH	43.41	28285833
215	Phosphorylation	QTKDYAESVGRKVRD CCHHHHHHHHHHHHH	23.00	-
274	Phosphorylation	TVNIMFGTPQEHRNM EEEECCCCHHHHCCC	15.55	25159016
377	Phosphorylation	RKERLLRSSADSLPG HHHHHHHHCCCCCCC	29.82	27087446
378	Phosphorylation	KERLLRSSADSLPGP HHHHHHHCCCCCCCC	29.66	27087446
381	Phosphorylation	LLRSSADSLPGPISR HHHHCCCCCCCCCCC	35.86	25521595
387	Phosphorylation	DSLPGPISRQPLGAA CCCCCCCCCCCCCCC	28.17	27087446
395	Phosphorylation	RQPLGAASGSSLKSQ CCCCCCCCCCCCCCC	38.38	29514104
397	Phosphorylation	PLGAASGSSLKSQPS CCCCCCCCCCCCCCC	29.96	29472430
398	Phosphorylation	LGAASGSSLKSQPSS CCCCCCCCCCCCCCC	43.26	29472430
401	Phosphorylation	ASGSSLKSQPSSQPL CCCCCCCCCCCCCCC	53.25	26239621
416	Phosphorylation	QSGQVLPSATPTPAA CCCCCCCCCCCCCCC	40.38	28285833
426	Phosphorylation	PTPAAPPTSQQELQA CCCCCCCCCHHHHHH	37.80	26239621
520	Phosphorylation	SSRLAPASTMASQRP HHHCCCCHHHHCCCC	20.04	27600695
521	O-linked_Glycosylation	SRLAPASTMASQRPV HHCCCCHHHHCCCCC	20.89	22517741
529	Phosphorylation	MASQRPVSSTGINFD HHCCCCCCCCCCCCC	25.51	26060331
530	Phosphorylation	ASQRPVSSTGINFDN HCCCCCCCCCCCCCC	30.77	26060331
531	Phosphorylation	SQRPVSSTGINFDNP CCCCCCCCCCCCCCH	34.28	26060331
555	Phosphorylation	IQSGPALSHLVSQTA HHHCHHHHHHHHHHH	19.51	26239621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NCOA5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NCOA5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NCOA5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NCOA5_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NCOA5_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29 AND SER-34, AND MASSSPECTROMETRY.	19367708 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377 AND SER-381, ANDMASS SPECTROMETRY.	17242355 [Abstract]